Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases (Q40437388)

20 September 2017

Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases (English)

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20 September 2017

Anita Morén

1

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20 September 2017

Takeshi Imamura

2

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20 September 2017

Kohei Miyazono

3

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20 September 2017

Carl-Henrik Heldin

4

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20 September 2017

Aristidis Moustakas

5

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20 September 2017

language of work or name

English

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publication date

6 April 2005

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Journal of Biological Chemistry

20 September 2017

9

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based on heuristic

inferred from page(s)

published in

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20 September 2017

280

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20 September 2017

23

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20 September 2017

22115-22123

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Smad-dependent and Smad-independent pathways in TGF-beta family signalling

20 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Regulation of TGF-beta signaling and its roles in progression of tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Mechanisms of TGF-beta signaling from cell membrane to the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Copper-inducible transcription: regulation by metal- and oxidative stress-responsive pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Smurf1 facilitates myogenic differentiation and antagonizes the bone morphogenetic protein-2-induced osteoblast conversion by targeting Smad5 for degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Smurf1 inhibits osteoblast differentiation and bone formation in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

dSmurf Selectively Degrades Decapentaplegic-activated MAD, and Its Overexpression Disrupts Imaginal Disc Development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

The DSmurf ubiquitin-protein ligase restricts BMP signaling spatially and temporally during Drosophila embryogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Smad4 protein stability is regulated by ubiquitin ligase SCF beta-TrCP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Sumoylation of Smad4, the Common Smad Mediator of Transforming Growth Factor-β Family Signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Regulation of Smad4 sumoylation and transforming growth factor-beta signaling by protein inhibitor of activated STAT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Activation of transforming growth factor-beta signaling by SUMO-1 modification of tumor suppressor Smad4/DPC4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Repression of Smad transcriptional activity by PIASy, an inhibitor of activated STAT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Repression of Smad4 transcriptional activity by SUMO modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Differential ubiquitination defines the functional status of the tumor suppressor Smad4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Transforming Growth Factor-β-mediated Signaling via the p38 MAP Kinase Pathway Activates Smad-dependent Transcription through SUMO-1 Modification of Smad4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Highwire regulates presynaptic BMP signaling essential for synaptic growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Ubiquitination and proteolysis of cancer-derived Smad4 mutants by SCFSkp2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Loss of Smad4 function in pancreatic tumors: C-terminal truncation leads to decreased stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor beta signaling by targeting Smads to the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Distinct endocytic pathways regulate TGF-β receptor signalling and turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of nodal receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Control of Smad7 stability by competition between acetylation and ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Jab1/CSN5, a component of the COP9 signalosome, regulates transforming growth factor beta signaling by binding to Smad7 and promoting its degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Nuclear factor YY1 inhibits transforming growth factor beta- and bone morphogenetic protein-induced cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-beta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Smad6 inhibits signalling by the TGF-beta superfamily.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Id2 and Id3 define the potency of cell proliferation and differentiation responses to transforming growth factor beta and bone morphogenetic protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Structural basis of heteromeric smad protein assembly in TGF-beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

In or out? The dynamics of Smad nucleocytoplasmic shuttling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

New insights into TGF-beta-Smad signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Regulation of cell polarity and protrusion formation by targeting RhoA for degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

The L3 loop and C-terminal phosphorylation jointly define Smad protein trimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Crystal Structure of a Phosphorylated Smad2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

A structural basis for mutational inactivation of the tumour suppressor Smad4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-beta signaling by Smad7

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

21 January 2018

Identifiers

DOI

10.1074/JBC.M414027200

1 reference

20 September 2017

1 reference