Adenomatous polyposis coli is down-regulated by the ubiquitin-proteasome pathway in a process facilitated by Axin (Q40517893)

21 September 2017

Adenomatous polyposis coli is down-regulated by the ubiquitin-proteasome pathway in a process facilitated by Axin (English)

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ubiquitin-proteasome system

21 September 2017

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Jongkyu Choi

1

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21 September 2017

Sun Young Park

2

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21 September 2017

Frank Costantini

3

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21 September 2017

Eek-Hoon Jho

4

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21 September 2017

Choun-Ki Joo

5

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21 September 2017

language of work or name

English

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publication date

7 September 2004

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Journal of Biological Chemistry

21 September 2017

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21 September 2017

279

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21 September 2017

47

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21 September 2017

49188-49198

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Linking colorectal cancer to Wnt signaling

21 September 2017

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https://api.crossref.org/works/10.1074%2FJBC.M404655200

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M404655200

The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

Axis determination in Xenopus involves biochemical interactions of axin, glycogen synthase kinase 3 and beta-catenin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

AXIN1 mutations but not deletions in cerebellar medulloblastomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleus

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M404655200

Tumor formation by genetic mutations in the components of the Wnt signaling pathway

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M404655200

Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

A mechanism for Wnt coreceptor activation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M404655200

You Wnt some, you lose some: oncogenes in the Wnt signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

The APC tumour suppressor has a nuclear export function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnover

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M404655200

Nuclear export of the APC tumour suppressor controls beta-catenin function in transcription

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M404655200

Themes and variations on ubiquitylation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M404655200

Adenomatous polyposis coli tumor suppressor protein has signaling activity in Xenopus laevis embryos resulting in the induction of an ectopic dorsoanterior axis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

Wnt-1 regulates free pools of catenins and stabilizes APC-catenin complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

Phosphorylation of axin, a Wnt signal negative regulator, by glycogen synthase kinase-3beta regulates its stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

beta-catenin is a target for the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

Proteasome regulates the delivery of LDL receptor-related protein into the degradation pathway

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M404655200

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

Dimer formation by an N-terminal coiled coil in the APC protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

Association of the APC tumor suppressor protein with catenins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

Axin-dependent phosphorylation of the adenomatous polyposis coli protein mediated by casein kinase 1epsilon

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

Structural basis of the Axin-adenomatous polyposis coli interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

Axin, a negative regulator of the wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

Functional domains of axin. Importance of the C terminus as an oligomerization domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

The ins and outs of APC and beta-catenin nuclear transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

The subcellular destinations of APC proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

Cell density and phosphorylation control the subcellular localization of adenomatous polyposis coli protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

Cell autonomous regulation of multiple Dishevelled-dependent pathways by mammalian Nkd

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

Beta-catenin regulation during the cell cycle: implications in G2/M and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

Nuclear accumulation of full-length and truncated adenomatous polyposis coli protein in tumor cells depends on proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

Identification of deletion mutations and three new genes at the familial polyposis locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

APC gene: database of germline and somatic mutations in human tumors and cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404655200

21 January 2018

Identifiers

DOI

10.1074/JBC.M404655200

1 reference

21 September 2017

1 reference