ATM-dependent CHK2 activation induced by anticancer agent, irofulven (Q40532748)

21 September 2017

ATM-dependent CHK2 activation induced by anticancer agent, irofulven (English)

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21 September 2017

Jian Wang

1

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21 September 2017

Timothy Wiltshire

2

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21 September 2017

Yutian Wang

3

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21 September 2017

Carmenza Mikell

4

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21 September 2017

Julian Burks

5

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21 September 2017

Cynthia Cunningham

6

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21 September 2017

Emily S Van Laar

7

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21 September 2017

Stephen J Waters

8

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21 September 2017

Eddie Reed

9

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21 September 2017

Weixin Wang

10

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21 September 2017

language of work or name

English

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publication date

20 July 2004

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Journal of Biological Chemistry

21 September 2017

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21 September 2017

279

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21 September 2017

38

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21 September 2017

39584-39592

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Enhanced antitumor activity of irofulven in combination with thiotepa or mitomycin C.

21 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Efficacy of MGI 114 (6-hydroxymethylacylfulvene, HMAF) against the mdr1/gp170 metastatic MV522 lung carcinoma xenograft

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Efficacy of MGI 114 (HMAF) against the MRP+ metastatic MV522 lung carcinoma xenograft.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

In vivo antitumour efficacy of MGI-114 (6-hydroxymethylacylfulvene, HMAF) in various human tumour xenograft models including several lung and gastric tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Activity of irofulven (6-hydroxymethylacylfulvene) in the treatment of glioblastoma multiforme-derived xenografts in athymic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Preclinical evaluation of illudins as anticancer agents: basis for selective cytotoxicity

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M400015200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Phase I study of irofulven (MGI 114), an acylfulvene illudin analog, in patients with acute leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Phase I and pharmacokinetic study of irofulven, a novel mushroom-derived cytotoxin, administered for five consecutive days every four weeks in patients with advanced solid malignancies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Enhanced antitumor activity of irofulven in combination with antimitotic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Anti-tumour compounds illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by transcription- and replication-coupled repair pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

The DNA damage response: putting checkpoints in perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Atm-deficient mice: a paradigm of ataxia telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M400015200

Cell cycle checkpoint signaling through the ATM and ATR kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

ATM-dependent phosphorylation of nibrin in response to radiation exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

The ataxia-telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Substrate specificities and identification of putative substrates of ATM kinase family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Allosteric effects mediate CHK2 phosphorylation of the p53 transactivation domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

p53, the cellular gatekeeper for growth and division

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Chk1 and Chk2 kinases in checkpoint control and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Cdc25 inhibited in vivo and in vitro by checkpoint kinases Cds1 and Chk1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

The Chk2 tumor suppressor is not required for p53 responses in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Questioning the role of checkpoint kinase 2 in the p53 DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Recombinant ATM protein complements the cellular A-T phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

ATM and ATR: networking cellular responses to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Enhanced phosphorylation of p53 by ATM in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

DNA damage induces phosphorylation of the amino terminus of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Increased accumulation of p53 protein in cisplatin-resistant ovarian cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

A role for ATR in the DNA damage-induced phosphorylation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Replication checkpoint kinase Cds1 regulates recombinational repair protein Rad60.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

MDC1 is required for the intra-S-phase DNA damage checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Drosophila Chk2 is required for DNA damage-mediated cell cycle arrest and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Chk2 regulates irradiation-induced, p53-mediated apoptosis in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Requirement of ATM in UVA-induced signaling and apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Integrating stress-response and cell-cycle checkpoint pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Impaired ionizing radiation-induced activation of a nuclear signal essential for phosphorylation of c-Jun by dually phosphorylated c-Jun amino-terminal kinases in ataxia telangiectasia fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400015200

21 January 2018

Identifiers

DOI

10.1074/JBC.M400015200

1 reference

21 September 2017

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