Limited role of N-terminal phosphoserine residues in the activation of transcription by p53. (Q40570035)

21 September 2017

title

Limited role of N-terminal phosphoserine residues in the activation of transcription by p53. (English)

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21 September 2017

Mark W Jackson

1

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21 September 2017

Mukesh K Agarwal

2

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21 September 2017

Munna L Agarwal

3

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21 September 2017

Archana Agarwal

4

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21 September 2017

Patricia Stanhope-Baker

5

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21 September 2017

Bryan R G Williams

6

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21 September 2017

George R Stark

7

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21 September 2017

language of work or name

English

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publication date

1 May 2004

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21 September 2017

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21 September 2017

volume

23

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21 September 2017

issue

25

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21 September 2017

page(s)

4477-4487

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A p53-dependent S-phase checkpoint helps to protect cells from DNA damage in response to starvation for pyrimidine nucleotides

21 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

Regulation of p53 expression by the RAS-MAP kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

p53-Mdm2--the affair that never ends

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

Post-translational modifications and activation of p53 by genotoxic stresses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

Stress signals utilize multiple pathways to stabilize p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

p14ARF links the tumour suppressors RB and p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

Phosphorylation of serines 15 and 37 is necessary for efficient accumulation of p53 following irradiation with UV.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

Regulation of the accumulation and function of p53 by phosphorylation of two residues within the domain that binds to Mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

An intact HDM2 RING-finger domain is required for nuclear exclusion of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

Regulation of ubiquitination and degradation of p53 in unstressed cells through C-terminal phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

MYC abrogates p53-mediated cell cycle arrest in N-(phosphonacetyl)-L-aspartate-treated cells, permitting CAD gene amplification

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

E1A signaling to p53 involves the p19(ARF) tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

WAF1, a potential mediator of p53 tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

The MDM2 RING-finger domain is required to promote p53 nuclear export

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

Mdm2 promotes the rapid degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

14-3-3sigma is a p53-regulated inhibitor of G2/M progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

p53 regulates a G2 checkpoint through cyclin B1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

Effect of phosphorylation on the structure and fold of transactivation domain of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

ESDN, a novel neuropilin-like membrane protein cloned from vascular cells with the longest secretory signal sequence among eukaryotes, is up-regulated after vascular injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

Stress-induced secretion of growth inhibitors: a novel tumor suppressor function of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

Regulation of p53 stability by Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

Dial 9-1-1 for p53: mechanisms of p53 activation by cellular stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

Activation of p53 by oncogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

The Arf tumor suppressor gene promotes hyaloid vascular regression during mouse eye development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

p53 has a direct apoptogenic role at the mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

Use of genetic suppressor elements to dissect distinct biological effects of separate p53 domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

The mdm-2 gene is induced in response to UV light in a p53-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

Cell-type and donor-specific transcriptional responses to interferon-alpha. Use of customized gene arrays.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

Mechanisms of G2 arrest in response to overexpression of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

Regulation of the G2/M transition by p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

21 January 2018

Surfing the p53 network

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

Human p14(ARF)-mediated cell cycle arrest strictly depends on intact p53 signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

p53-independent functions of the p19(ARF) tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

Nucleolar Arf sequesters Mdm2 and activates p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

The p53-mdm-2 autoregulatory feedback loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

Role of Pin1 in the regulation of p53 stability and p21 transactivation, and cell cycle checkpoints in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

p19ARF links the tumour suppressor p53 to Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

p53- and Mdm2-Independent Repression of NF-κB Transactivation by the ARF Tumor Suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

Comparative study of the p53-mdm2 and p53-MDMX interfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

7 January 2021

Inhibition of v-Abl transformation by p53 and p19ARF

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

7 January 2021

Loss of p19ARF enhances the defects of Mdm2 overexpression in the mammary gland

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

7 January 2021

Connective tissue growth factor binds vascular endothelial growth factor (VEGF) and inhibits VEGF-induced angiogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

7 January 2021

Phosphorylation of p53 serine 15 increases interaction with CBP

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

7 January 2021

Differential activation of p53 targets in cells treated with ultraviolet radiation that undergo both apoptosis and growth arrest

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

7 January 2021

Differential regulation of the p21/WAF-1 and mdm2 genes after high-dose UV irradiation: p53-dependent and p53-independent regulation of the mdm2 gene.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207575

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1207575

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Dimensions Publication ID

21 September 2017

1010985543

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1 reference