From autoinhibition to inhibition in trans: the Raf-1 regulatory domain inhibits Rok-alpha kinase activity (Q41909915)

14 October 2017

From autoinhibition to inhibition in trans: the Raf-1 regulatory domain inhibits Rok-alpha kinase activity (English)

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14 October 2017

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14

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14 October 2017

Tony Ng

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Daniela Piazzolla

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object named as

Daniela Piazzolla

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14 October 2017

3

Katrin Meissl

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14 October 2017

8

Karin Ehrenreiter

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14 October 2017

Théodora Niault

1

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14 October 2017

Izabela Sobczak

2

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14 October 2017

Gregory Weitsman

4

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14 October 2017

Gabriele Maurer

6

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14 October 2017

Florian Kern

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14 October 2017

Matthias Hamerl

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14 October 2017

Ismail Moarefi

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14 October 2017

Thomas Leung

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14 October 2017

Oliviero Carugo

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14 October 2017

language of work or name

English

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publication date

1 November 2009

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14 October 2017

Journal of Cell Biology

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187

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3

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335-342

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describes a project that uses

14 October 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2779248/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Applications for ROCK kinase inhibition

5 June 2018

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Prediction of transition metal-binding sites from apo protein structures.

5 June 2018

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Plasma membrane nanoswitches generate high-fidelity Ras signal transduction

5 June 2018

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Imaging proteins in vivo using fluorescence lifetime microscopy

5 June 2018

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ROCK- and myosin-dependent matrix deformation enables protease-independent tumor-cell invasion in vivo

5 June 2018

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Raf-1 sets the threshold of Fas sensitivity by modulating Rok-alpha signaling

5 June 2018

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Raf-1 regulates Rho signaling and cell migration

5 June 2018

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Ras binding opens c-Raf to expose the docking site for mitogen-activated protein kinase kinase.

5 June 2018

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Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1.

5 June 2018

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PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulation

5 June 2018

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Multiphoton-FLIM quantification of the EGFP-mRFP1 FRET pair for localization of membrane receptor-kinase interactions

5 June 2018

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The RAF proteins take centre stage

5 June 2018

1 reference

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Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis

5 June 2018

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Predicting metal-binding site residues in low-resolution structural models.

5 June 2018

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Mitogen-activated protein kinase feedback phosphorylation regulates MEK1 complex formation and activation during cellular adhesion

5 June 2018

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Structural insights into the interaction of ROCKI with the switch regions of RhoA

5 June 2018

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Parallel coiled-coil association of the RhoA-binding domain in Rho-kinase

5 June 2018

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Rocks: multifunctional kinases in cell behaviour

5 June 2018

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Structural determinants of Ras-Raf interaction analyzed in live cells

5 June 2018

1 reference

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Characterization of RhoA-binding kinase ROKalpha implication of the pleckstrin homology domain in ROKalpha function using region-specific antibodies

5 June 2018

1 reference

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Post-transcriptional down-regulation of ROCKI/Rho-kinase through an MEK-dependent pathway leads to cytoskeleton disruption in Ras-transformed fibroblasts

5 June 2018

1 reference

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Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779248

Dephosphorylation of Ser-259 regulates Raf-1 membrane association

5 June 2018

1 reference

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Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene

5 June 2018

1 reference

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Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility

5 June 2018

1 reference

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The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development

5 June 2018

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Comparative protein structure modeling of genes and genomes

5 June 2018

1 reference

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The COOH terminus of Rho-kinase negatively regulates rho-kinase activity.

5 June 2018

1 reference

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RhoA-binding kinase alpha translocation is facilitated by the collapse of the vimentin intermediate filament network

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779248

Autoregulation of the Raf-1 serine/threonine kinase

5 June 2018

1 reference

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The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779248

The solution structure of the Raf-1 cysteine-rich domain: a novel ras and phospholipid binding site

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779248

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779248

MDA-468, a human breast cancer cell line with a high number of epidermal growth factor (EGF) receptors, has an amplified EGF receptor gene and is growth inhibited by EGF.

5 June 2018

1 reference

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Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779248

Raf-1 addiction in Ras-induced skin carcinogenesis

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779248

A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779248

Role of Raf-1 and FAK in cell density-dependent regulation of integrin-dependent activation of MAP kinase.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779248

MEK mediates v-Src-induced disruption of the actin cytoskeleton via inactivation of the Rho-ROCK-LIM kinase pathway

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2779248

Elucidation of binding determinants and functional consequences of Ras/Raf-cysteine-rich domain interactions

18 August 2018

1 reference

12 December 2020

Simple fed-batch technique for high cell density cultivation of Escherichia coli

1 reference

12 December 2020

Activity of plasma membrane-recruited Raf-1 is regulated by Ras via the Raf zinc finger

1 reference

12 December 2020

ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motility

1 reference

12 December 2020

Using multiple structure alignments, fast model building, and energetic analysis in fold recognition and homology modeling

1 reference

12 December 2020

Identifiers

DOI

10.1083/JCB.200906178

1 reference

14 October 2017

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14 October 2017

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