Down-regulation of Rac GTPase-activating protein OCRL1 causes aberrant activation of Rac1 in osteoarthritis development (Q42145534)

17 October 2017

Down-regulation of Rac GTPase-activating protein OCRL1 causes aberrant activation of Rac1 in osteoarthritis development (English)

1 reference

17 October 2017

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8

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10 June 2020

Yi Ting Zhou

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10 June 2020

author name string

Shouan Zhu

1

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10 June 2020

Jun Dai

2

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10 June 2020

Huanhuan Liu

3

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10 June 2020

Xiaoxia Cong

4

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10 June 2020

Yishan Chen

5

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10 June 2020

Yan Wu

6

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10 June 2020

Hu Hu

7

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10 June 2020

Hong Wei Ouyang

9

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10 June 2020

publication date

1 May 2015

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17 October 2017

Arthritis & Rheumatology

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10 June 2020

volume

67

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10 June 2020

page(s)

2154-2163

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10 June 2020

issue

8

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Osteoarthritis and therapy.

10 June 2020

cites work

1 reference

Type X collagen gene regulation by Runx2 contributes directly to its hypertrophic chondrocyte-specific expression in vivo

21 January 2018

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ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

21 January 2018

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Cartilage biology in osteoarthritis--lessons from developmental biology

21 January 2018

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Chondrocyte hypertrophy and osteoarthritis: role in initiation and progression of cartilage degeneration?

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Rac activation and inactivation control plasticity of tumor cell movement

21 January 2018

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Wnt and Rho GTPase signaling in osteoarthritis development and intervention: implications for diagnosis and therapy.

21 January 2018

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Rac1 is required for matrix metalloproteinase 13 production by chondrocytes in response to fibronectin fragments

21 January 2018

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Inhibition of Rac1 activity by controlled release of NSC23766 from chitosan microspheres effectively ameliorates osteoarthritis development in vivo

21 January 2018

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GEFs and GAPs: critical elements in the control of small G proteins

21 January 2018

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Vav GEFs are required for beta2 integrin-dependent functions of neutrophils

21 January 2018

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P-Rex1 and Vav1 cooperate in the regulation of formyl-methionyl-leucyl-phenylalanine-dependent neutrophil responses

21 January 2018

1 reference

Vav2 is required for cell spreading

21 January 2018

1 reference

Structure and function of the Lowe syndrome protein OCRL1.

21 January 2018

1 reference

Ocrl1, a PtdIns(4,5)P(2) 5-phosphatase, is localized to the trans-Golgi network of fibroblasts and epithelial cells

21 January 2018

1 reference

The inositol polyphosphate 5-phosphatase Ocrl associates with endosomes that are partially coated with clathrin

21 January 2018

1 reference

The Lowe's oculocerebrorenal syndrome gene encodes a protein highly homologous to inositol polyphosphate-5-phosphatase

21 January 2018

1 reference

Lowe syndrome protein OCRL1 interacts with clathrin and regulates protein trafficking between endosomes and the trans-Golgi network

21 January 2018

1 reference

A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway

21 January 2018

1 reference

Rab35 GTPase and OCRL phosphatase remodel lipids and F-actin for successful cytokinesis.

21 January 2018

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The deficiency of PIP2 5-phosphatase in Lowe syndrome affects actin polymerization

21 January 2018

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Phosphatidylinositol-4-phosphate 5-kinase localized on the plasma membrane is essential for yeast cell morphogenesis

21 January 2018

1 reference

Spectrum of mutations in the OCRL1 gene in the Lowe oculocerebrorenal syndrome

21 January 2018

1 reference

Lowe syndrome protein OCRL1 interacts with Rac GTPase in the trans-Golgi network

21 January 2018

1 reference

Role of interleukin-1 and tumor necrosis factor alpha in matrix degradation of human osteoarthritic cartilage.

21 January 2018

1 reference

Latent KSHV infection increases the vascular permeability of human endothelial cells

21 January 2018

1 reference

Rac1/Cdc42 and RhoA GTPases antagonistically regulate chondrocyte proliferation, hypertrophy, and apoptosis

21 January 2018

1 reference

Genetic ablation of Rac1 in cartilage results in chondrodysplasia.

21 January 2018

1 reference

Rac1 mediates STAT3 activation by autocrine IL-6

21 January 2018

1 reference

Phosphoinositide 3-kinase δ regulates migration and invasion of synoviocytes in rheumatoid arthritis.

21 January 2018

1 reference

Current knowledge of the large RhoGAP family of proteins

21 January 2018

1 reference

The cellular and physiological functions of the Lowe syndrome protein OCRL1

21 January 2018

1 reference

The BNIP-2 and Cdc42GAP homology (BCH) domain of p50RhoGAP/Cdc42GAP sequesters RhoA from inactivation by the adjacent GTPase-activating protein domain.

21 January 2018

1 reference

Dent Disease with mutations in OCRL1

21 January 2018

1 reference

Novel OCRL1 mutations in patients with the phenotype of Dent disease.

21 January 2018

1 reference

Phosphoinositides in cell regulation and membrane dynamics

21 January 2018

1 reference

KIF5B transports BNIP-2 to regulate p38 mitogen-activated protein kinase activation and myoblast differentiation.

21 January 2018

1 reference

Endocytic trafficking of Rac is required for the spatial restriction of signaling in cell migration

21 January 2018

1 reference

Rab proteins as membrane organizers

21 January 2018

1 reference

Recruitment of OCRL and Inpp5B to phagosomes by Rab5 and APPL1 depletes phosphoinositides and attenuates Akt signaling

21 January 2018

1 reference

Adiponectin inhibits osteoclastogenesis and bone resorption via APPL1-mediated suppression of Akt1.

21 January 2018

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Actin filament uncapping localizes to ruffling lamellae and rocketing vesicles

21 January 2018

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