Phosphoproteomic evaluation of pharmacological inhibition of leucine-rich repeat kinase 2 reveals significant off-target effects of LRRK-2-IN-1. (Q42263195)

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scientific article published on 11 November 2013

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English	Phosphoproteomic evaluation of pharmacological inhibition of leucine-rich repeat kinase 2 reveals significant off-target effects of LRRK-2-IN-1.	scientific article published on 11 November 2013

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scholarly article

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Europe PubMed Central

PubMed publication ID

19 October 2017

Phosphoproteomic evaluation of pharmacological inhibition of leucine-rich repeat kinase 2 reveals significant off-target effects of LRRK-2-IN-1. (English)

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Europe PubMed Central

PubMed publication ID

19 October 2017

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Gregory C Luerman

1

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19 October 2017

Chuong Nguyen

2

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19 October 2017

Harry Samaroo

3

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19 October 2017

Paula Loos

4

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19 October 2017

Hualin Xi

5

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19 October 2017

Andres Hurtado-Lorenzo

6

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19 October 2017

Elie Needle

7

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19 October 2017

G Stephen Noell

8

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19 October 2017

Paul Galatsis

9

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19 October 2017

John Dunlop

10

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19 October 2017

Kieran F Geoghegan

11

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19 October 2017

Warren D Hirst

12

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19 October 2017

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publication date

11 November 2013

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19 October 2017

Journal of Neurochemistry

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19 October 2017

128

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19 October 2017

4

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19 October 2017

561-576

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19 October 2017

Investigation of leucine-rich repeat kinase 2 : enzymological properties and novel assays.

1 reference

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21 January 2018

Leucine-rich repeat kinase 2 functionally interacts with microtubules and kinase-dependently modulates cell migration

1 reference

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21 January 2018

Rac1 protein rescues neurite retraction caused by G2019S leucine-rich repeat kinase 2 (LRRK2)

1 reference

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21 January 2018

(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD.

1 reference

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21 January 2018

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

1 reference

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21 January 2018

Identification of potential protein interactors of Lrrk2

1 reference

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21 January 2018

Association of variants at 1q32 and STAT3 with ankylosing spondylitis suggests genetic overlap with Crohn's disease

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21 January 2018

Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2.

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21 January 2018

A rat model of progressive nigral neurodegeneration induced by the Parkinson's disease-associated G2019S mutation in LRRK2.

1 reference

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21 January 2018

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization

1 reference

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21 January 2018

The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling

1 reference

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21 January 2018

Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus.

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21 January 2018

Discovery of highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors

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LRRK2 is involved in the IFN-gamma response and host response to pathogens

1 reference

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21 January 2018

Parkinson's disease-linked leucine-rich repeat kinase 2(R1441G) mutation increases proinflammatory cytokine release from activated primary microglial cells and resultant neurotoxicity.

1 reference

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21 January 2018

The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro

1 reference

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21 January 2018

Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

1 reference

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21 January 2018

Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1.

1 reference

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21 January 2018

Age-related changes in HSP25 expression in basal ganglia and cortex of F344/BN rats

1 reference

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21 January 2018

ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2

1 reference

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21 January 2018

BMK1 mediates growth factor-induced cell proliferation through direct cellular activation of serum and glucocorticoid-inducible kinase

1 reference

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21 January 2018

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

1 reference

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21 January 2018

LRRK2 enhances oxidative stress-induced neurotoxicity via its kinase activity

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12483

21 January 2018

Screening for novel LRRK2 inhibitors using a high-throughput TR-FRET cellular assay for LRRK2 Ser935 phosphorylation

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12483

21 January 2018

LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors

1 reference

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21 January 2018

Big mitogen-activated kinase regulates multiple members of the MEF2 protein family

1 reference

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21 January 2018

Impaired inflammatory responses in murine Lrrk2-knockdown brain microglia

1 reference

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21 January 2018

Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease

1 reference

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21 January 2018

The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease

1 reference

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21 January 2018

Progressive degeneration of human neural stem cells caused by pathogenic LRRK2

1 reference

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21 January 2018

Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomas

1 reference

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21 January 2018

The familial Parkinsonism gene LRRK2 regulates neurite process morphology

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12483

21 January 2018

LRRK2 kinase inhibition prevents pathological microglial phagocytosis in response to HIV-1 Tat protein

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12483

21 January 2018

LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12483

21 January 2018

A QUICK screen for Lrrk2 interaction partners--leucine-rich repeat kinase 2 is involved in actin cytoskeleton dynamics.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12483

21 January 2018

LRRK2 inhibition attenuates microglial inflammatory responses

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12483

21 January 2018

Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12483

21 January 2018

PKCzeta decreases eNOS protein stability via inhibitory phosphorylation of ERK5.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12483

21 January 2018

Leucine-rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin-like protein

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12483

21 January 2018

LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: impairment of the kinase activity by Parkinson's disease-associated mutations

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12483

21 January 2018

Small heat shock proteins protect against alpha-synuclein-induced toxicity and aggregation

1 reference

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21 January 2018

G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12483

21 January 2018

Enhanced dendritogenesis and axogenesis in hippocampal neuroblasts of LRRK2 knockout mice

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12483

21 January 2018

CARHSP1 is required for effective tumor necrosis factor alpha mRNA stabilization and localizes to processing bodies and exosomes

1 reference

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21 January 2018

Identification and characterization of a leucine-rich repeat kinase 2 (LRRK2) consensus phosphorylation motif

1 reference

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21 January 2018

Heat shock protein 27 in neuronal survival and neurite outgrowth

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21 January 2018

An iterative statistical approach to the identification of protein phosphorylation motifs from large-scale data sets

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21 January 2018

Doublecortin-like kinase enhances dendritic remodelling and negatively regulates synapse maturation

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21 January 2018

Identification of pharmacological inhibitors of the MEK5/ERK5 pathway

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The genetics of Crohn's disease

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21 January 2018

Girdin is an intrinsic regulator of neuroblast chain migration in the rostral migratory stream of the postnatal brain.

1 reference

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21 January 2018

Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12483

21 January 2018

MAPK-pathway activity, Lrrk2 G2019S, and Parkinson's disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12483

21 January 2018

ERK5 protein promotes, whereas MEK1 protein differentially regulates, the Toll-like receptor 2 protein-dependent activation of human endothelial cells and monocytes

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12483

21 January 2018

Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12483

21 January 2018

Pharmacological Inhibition of BMK1 Suppresses Tumor Growth through Promyelocytic Leukemia Protein

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21 January 2018

Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity

1 reference

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21 January 2018

Signal Transduction Protein Array Analysis Links LRRK2 to Ste20 Kinases and PKC Zeta That Modulate Neuronal Plasticity

1 reference

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Genomewide association study of leprosy

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Selective Isolation at the Femtomole Level of Phosphopeptides from Proteolytic Digests Using 2D-NanoLC-ESI-MS/MS and Titanium Oxide Precolumns

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A frequent LRRK2 gene mutation associated with autosomal dominant Parkinson's disease

1 reference

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21 January 2018

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10.1111/JNC.12483

1 reference

Europe PubMed Central

PubMed publication ID

19 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

19 October 2017

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