P-glycoprotein catalytic mechanism: studies of the ADP-vanadate inhibited state (Q44387458)

2 December 2017

title

P-glycoprotein catalytic mechanism: studies of the ADP-vanadate inhibited state (English)

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2 December 2017

1

Ina L Urbatsch

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2 December 2017

Grace A Tyndall

2

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2 December 2017

Gregory Tombline

series ordinal

3

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2 December 2017

Alan E Senior

series ordinal

4

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2 December 2017

language of work or name

English

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publication date

1 April 2003

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Journal of Biological Chemistry

2 December 2017

number of pages

9

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based on heuristic

inferred from page(s)

published in

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2 December 2017

volume

278

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2 December 2017

issue

25

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2 December 2017

page(s)

23171-23179

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Biochemistry of multidrug resistance mediated by the multidrug transporter

2 December 2017

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Biochemical, cellular, and pharmacological aspects of the multidrug transporter

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Determining the structure and mechanism of the human multidrug resistance P-glycoprotein using cysteine-scanning mutagenesis and thiol-modification techniques

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The catalytic cycle of P-glycoprotein

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The mechanism of action of multidrug-resistance-linked P-glycoprotein

21 January 2018

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The homodimeric ATP-binding cassette transporter LmrA mediates multidrug transport by an alternating two-site (two-cylinder engine) mechanism

21 January 2018

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Mechanism of coupling of transport to hydrolysis in bacterial ATP-binding cassette transporters

21 January 2018

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Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle

21 January 2018

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Cross-linking of human multidrug resistance P-glycoprotein by the substrate, tris-(2-maleimidoethyl)amine, is altered by ATP hydrolysis. Evidence for rotation of a transmembrane helix.

21 January 2018

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Vanadate trapping of nucleotide at the ATP-binding sites of human multidrug resistance P-glycoprotein exposes different residues to the drug-binding site

21 January 2018

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Stoichiometry and affinity of nucleotide binding to P-glycoprotein during the catalytic cycle

21 January 2018

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Conserved walker A Ser residues in the catalytic sites of P-glycoprotein are critical for catalysis and involved primarily at the transition state step.

21 January 2018

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Drug-stimulated ATPase activity of human P-glycoprotein is blocked by disulfide cross-linking between the nucleotide-binding sites.

21 January 2018

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The "LSGGQ" motif in each nucleotide-binding domain of human P-glycoprotein is adjacent to the opposing walker A sequence

21 January 2018

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Drug binding in human P-glycoprotein causes conformational changes in both nucleotide-binding domains.

21 January 2018

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Structure of the multidrug resistance P-glycoprotein to 2.5 nm resolution determined by electron microscopy and image analysis.

21 January 2018

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Projection structure of P-glycoprotein by electron microscopy. Evidence for a closed conformation of the nucleotide binding domains

21 January 2018

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FRET analysis indicates that the two ATPase active sites of the P-glycoprotein multidrug transporter are closely associated.

21 January 2018

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Vanadate-catalyzed photocleavage of the signature motif of an ATP-binding cassette (ABC) transporter

21 January 2018

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ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer

21 January 2018

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The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism

21 January 2018

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RETRACTED: Structure of MsbA from E. coli: a homolog of the multidrug resistance ATP binding cassette (ABC) transporters

21 January 2018

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ATP hydrolysis by multidrug-resistance protein from Chinese hamster ovary cells

21 January 2018

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Use of chemical chaperones in the yeast Saccharomyces cerevisiae to enhance heterologous membrane protein expression: high-yield expression and purification of human P-glycoprotein

21 January 2018

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Extraction of Hoechst 33342 from the cytoplasmic leaflet of the plasma membrane by P-glycoprotein.

21 January 2018

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Transport of LDS-751 from the cytoplasmic leaflet of the plasma membrane by the rhodamine-123-selective site of P-glycoprotein.

21 January 2018

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A novel electron paramagnetic resonance approach to determine the mechanism of drug transport by P-glycoprotein

21 January 2018

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Structure of the ArsA ATPase: the catalytic subunit of a heavy metal resistance pump

21 January 2018

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P-glycoprotein Is Stably Inhibited by Vanadate-induced Trapping of Nucleotide at a Single Catalytic Site

21 January 2018

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X-ray structure of the magnesium(II).ADP.vanadate complex of the Dictyostelium discoideum myosin motor domain to 1.9 A resolution

21 January 2018

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Mutations in either nucleotide-binding site of P-glycoprotein (Mdr3) prevent vanadate trapping of nucleotide at both sites.

21 January 2018

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Mutational analysis of conserved carboxylate residues in the nucleotide binding sites of P-glycoprotein

21 January 2018

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Transition-state formation in ATPase-negative mutants of human MDR1 protein

21 January 2018

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Large scale purification of detergent-soluble P-glycoprotein from Pichia pastoris cells and characterization of nucleotide binding properties of wild-type, Walker A, and Walker B mutant proteins.

21 January 2018

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Biochemical characterization of the human RAD51 protein. I. ATP hydrolysis

21 January 2018

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Purification and characterization of N-glycosylation mutant mouse and human P-glycoproteins expressed in Pichia pastoris cells

21 January 2018

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Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis

21 January 2018

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Investigation of the role of glutamine-471 and glutamine-1114 in the two catalytic sites of P-glycoprotein

21 January 2018

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The vinblastine binding site adopts high- and low-affinity conformations during a transport cycle of P-glycoprotein

21 January 2018

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Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state

21 January 2018

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Trapping the transition state of an ATP-binding cassette transporter: evidence for a concerted mechanism of maltose transport

21 January 2018

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The crystal structure of the MJ0796 ATP-binding cassette. Implications for the structural consequences of ATP hydrolysis in the active site of an ABC transporter

21 January 2018

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Evidence for the vectorial nature of drug (substrate)-stimulated ATP hydrolysis by human P-glycoprotein

21 January 2018

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21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M301957200

1 reference

2 December 2017

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