Regulation of gene expression by the amyloid precursor protein: inhibition of the JNK/c-Jun pathway. (Q42471712)

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6 January 2020

title

Regulation of gene expression by the amyloid precursor protein: inhibition of the JNK/c-Jun pathway (English)

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6 January 2020

4

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6 January 2020

author name string

Kögel D

series ordinal

1

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6 January 2020

Schomburg R

series ordinal

2

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6 January 2020

Copanaki E

series ordinal

3

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6 January 2020

language of work or name

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1 January 2005

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Cell Death & Differentiation

6 January 2020

published in

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volume

12

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6 January 2020

issue

1

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6 January 2020

page(s)

1-9

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https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401495

6 January 2020

exact match

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The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner

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c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK

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The amyloid precursor protein protects PC12 cells against endoplasmic reticulum stress-induced apoptosis

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Elevated vulnerability to oxidative stress-induced cell death and activation of caspase-3 by the Swedish amyloid precursor protein mutation

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Neurotoxic mechanisms caused by the Alzheimer's disease-linked Swedish amyloid precursor protein mutation: oxidative stress, caspases, and the JNK pathway

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Transcriptional upregulation of SPARC, in response to c-Jun overexpression, contributes to increased motility and invasion of MCF7 breast cancer cells

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c-JUN gene induction and AP-1 activity is regulated by a JNK-dependent pathway in hypoxic HepG2 cells

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ASK1-signaling promotes c-Myc protein stability during apoptosis

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Fatal shift of signal transduction is an integral part of neuronal differentiation: JNKs realize TNFalpha-mediated apoptosis in neuronlike, but not naive, PC12 cells.

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Identifiers

DOI

10.1038/SJ.CDD.4401495

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15592359%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

6 January 2020

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