Mdm-2 binding and TAF(II)31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21. (Q42526729)

1 November 2017

title

Mdm-2 binding and TAF(II)31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21. (English)

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1 November 2017

James R Jabbur

1

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1 November 2017

Amy D Tabor

2

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1 November 2017

Xiaodong Cheng

3

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1 November 2017

Hua Wang

4

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1 November 2017

Motonari Uesugi

5

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1 November 2017

Guillermina Lozano

6

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1 November 2017

Wei Zhang

7

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1 November 2017

language of work or name

English

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publication date

1 October 2002

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1 November 2017

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1 November 2017

volume

21

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1 November 2017

issue

46

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1 November 2017

page(s)

7100-7113

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1205856

1 November 2017

exact match

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cites work

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p300/MDM2 complexes participate in MDM2-mediated p53 degradation

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Identification of a sequence element from p53 that signals for Mdm2-targeted degradation

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Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

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p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner

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21 January 2018

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p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage

21 January 2018

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The p53 activation domain binds the TATA box-binding polypeptide in Holo-TFIID, and a neighboring p53 domain inhibits transcription

21 January 2018

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Human TAFII31 protein is a transcriptional coactivator of the p53 protein

21 January 2018

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Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

p53 is phosphorylated in vitro and in vivo by an ultraviolet radiation-induced protein kinase characteristic of the c-Jun kinase, JNK1.

21 January 2018

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A novel form of Epstein-Barr virus latency in normal B cells in vivo

21 January 2018

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Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

21 January 2018

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Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression

21 January 2018

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Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

DNA damage activates p53 through a phosphorylation-acetylation cascade

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

Wild-type p53 binds to the TATA-binding protein and represses transcription

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

DNA damage induces phosphorylation of the amino terminus of p53

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

c-Abl neutralizes the inhibitory effect of Mdm2 on p53.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

A role for ATR in the DNA damage-induced phosphorylation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

Induced alpha helix in the VP16 activation domain upon binding to a human TAF

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

The alpha-helical FXXPhiPhi motif in p53: TAF interaction and discrimination by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

Mutations in serines 15 and 20 of human p53 impair its apoptotic activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

GADD45 induction of a G2/M cell cycle checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

DNA-dependent protein kinase acts upstream of p53 in response to DNA damage

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

The p53-mdm-2 autoregulatory feedback loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

Comparative study of the p53-mdm2 and p53-MDMX interfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

7 January 2021

UVB-induced cyclobutane pyrimidine dimer frequency correlates with skin cancer mutational hotspots in p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

7 January 2021

Protein kinase CK1 is a p53-threonine 18 kinase which requires prior phosphorylation of serine 15

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

7 January 2021

Human p53 is phosphorylated on serines 6 and 9 in response to DNA damage-inducing agents

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

7 January 2021

RB regulates the stability and the apoptotic function of p53 via MDM2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

7 January 2021

DNA damage-induced phosphorylation of p53 at serine 20 correlates with p21 and Mdm-2 induction in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

7 January 2021

Thermodynamics of p53 binding to hdm2(1-126): effects of phosphorylation and p53 peptide length

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

7 January 2021

Phosphorylation of p53 serine 15 increases interaction with CBP

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

7 January 2021

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

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Signaling to p53: breaking the MDM2-p53 circuit

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205856

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Murine double minute (MDM2) blocks p53-coactivator interaction, a new mechanism for inhibition of p53-dependent gene expression

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1205856

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Dimensions Publication ID

1 November 2017

1053467781

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1 reference