WIP1 phosphatase modulates the Hedgehog signaling by enhancing GLI1 function. (Q42676343)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23146903%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

title

WIP1 phosphatase modulates the Hedgehog signaling by enhancing GLI1 function (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23146903%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23146903%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

Barbara Stecca

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23146903%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

author name string

S Pandolfi

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23146903%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

V Montagnani

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23146903%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

J Y Penachioni

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23146903%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

M C Vinci

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23146903%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

L Borgognoni

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23146903%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

language of work or name

English

0 references

publication date

12 November 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23146903%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23146903%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

volume

32

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23146903%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

issue

40

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23146903%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

page(s)

4737-4747

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23146903%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/onc.2012.502

17 February 2020

exact match

0 references

cites work

Hedgehog signaling in animal development: paradigms and principles

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Hedgehog: functions and mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Tissue repair and stem cell renewal in carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

The Hedgehog's tale: developing strategies for targeting cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Patching the gaps in Hedgehog signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Hedgehog signaling in development and cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Context-dependent regulation of the GLI code in cancer by HEDGEHOG and non-HEDGEHOG signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Human homolog of patched, a candidate gene for the basal cell nevus syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Activating Smoothened mutations in sporadic basal-cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Selective modulation of Hedgehog/GLI target gene expression by epidermal growth factor signaling in human keratinocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

The crosstalk of mTOR/S6K1 and Hedgehog pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

E2F1 modulates p38 MAPK phosphorylation via transcriptional regulation of ASK1 and Wip1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Mice deficient for the wild-type p53-induced phosphatase gene (Wip1) exhibit defects in reproductive organs, immune function, and cell cycle control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Wip1 regulates the generation of new neural cells in the adult olfactory bulb through p53-dependent cell cycle control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Wip1-dependent regulation of autophagy, obesity, and atherosclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Medulloblastomas overexpress the p53-inactivating oncogene WIP1/PPM1D

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Augmented cancer resistance and DNA damage response phenotypes in PPM1D null mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Wip1 phosphatase regulates p53-dependent apoptosis of stem cells and tumorigenesis in the mouse intestine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

The role of the MKK6/p38 MAPK pathway in Wip1-dependent regulation of ErbB2-driven mammary gland tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Over-expression of wild-type p53-induced phosphatase 1 confers poor prognosis of patients with gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Small molecule modulation of Smoothened activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Vertebrate Smoothened functions at the primary cilium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Patched1 regulates hedgehog signaling at the primary cilium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

A novel protein-processing domain in Gli2 and Gli3 differentially blocks complete protein degradation by the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Dual degradation signals control Gli protein stability and tumor formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

PPM1D silencing by RNA interference inhibits proliferation and induces apoptosis in breast cancer cell lines with wild-type p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Hedgehog-GLI signaling drives self-renewal and tumorigenicity of human melanoma-initiating cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

WIP1 enhances tumor formation in a sonic hedgehog-dependent model of medulloblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Protein phosphatase 2A and rapamycin regulate the nuclear localization and activity of the transcription factor GLI3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Point mutations in GLI3 lead to misregulation of its subcellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

PP2A:B56epsilon is required for eye induction and eye field separation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

The antagonistic action of B56-containing protein phosphatase 2As and casein kinase 2 controls the phosphorylation and Gli turnover function of Daz interacting protein 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

The type 2C phosphatase Wip1: an oncogenic regulator of tumor suppressor and DNA damage response pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

The sonic hedgehog signaling system as a bistable genetic switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Malignant melanoma: genetics and therapeutics in the genomic era.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Melanoma biology and new targeted therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

The hedgehog pathway transcription factor GLI1 promotes malignant behavior of cancer cells by up-regulating osteopontin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Clinical experience with Hedgehog pathway inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Optimization of a cyclic peptide inhibitor of Ser/Thr phosphatase PPM1D (Wip1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Wip1 confers G2 checkpoint recovery competence by counteracting p53-dependent transcriptional repression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

WAF1, a potential mediator of p53 tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Wip1 Phosphatase Modulates ATM-Dependent Signaling Pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Lack of allelic deletion and point mutation as mechanisms of p53 activation in human malignant melanoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

Development of a substrate-based cyclic phosphopeptide inhibitor of protein phosphatase 2Cdelta, Wip1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.502

31 March 2020

Identifiers

DOI

10.1038/ONC.2012.502

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23146903%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

17 February 2020

1006878030

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23146903%20AND%20SRC:MED&resulttype=core&format=json