Mitochondria and PGC-1α in Aging and Age-Associated Diseases (Q42738266)

6 November 2017

1 reference

title

Mitochondria and PGC-1α in Aging and Age-Associated Diseases (English)

1 reference

6 November 2017

1 reference

Tina Wenz

1

1 reference

6 November 2017

5 May 2011

1 reference

Journal of Aging Research

6 November 2017

1 reference

6 November 2017

2011

1 reference

6 November 2017

810619

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Creative Commons Attribution 3.0 Unported

6 November 2017

start time

1 January 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

1 reference

April 2022 Public Data File from Crossref

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27 May 2018

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27 May 2018

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27 May 2018

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27 May 2018

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27 May 2018

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27 May 2018

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27 May 2018

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27 May 2018

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Identification of novel targets for PGC-1alpha and histone deacetylase inhibitors in neuroblastoma cells

27 May 2018

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A PGC-1alpha-O-GlcNAc transferase complex regulates FoxO transcription factor activity in response to glucose

27 May 2018

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Insulin/IGF-1 and ROS signaling pathway cross-talk in aging and longevity determination

27 May 2018

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Nuclear control of respiratory chain expression by nuclear respiratory factors and PGC-1-related coactivator

27 May 2018

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RETRACTED: Activation of the PPAR/PGC-1alpha pathway prevents a bioenergetic deficit and effectively improves a mitochondrial myopathy phenotype

27 May 2018

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27 May 2018

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High-fat diets cause insulin resistance despite an increase in muscle mitochondria

27 May 2018

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How is AMPK activity regulated in skeletal muscles during exercise?

27 May 2018

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27 May 2018

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27 May 2018

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Role of mitochondrial dysfunction in insulin resistance

27 May 2018

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Mitochondria--a nexus for aging, calorie restriction, and sirtuins?

27 May 2018

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Diet, energy metabolism and mitochondrial biogenesis

27 May 2018

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Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways

27 May 2018

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Dynamic regulation of PGC-1alpha localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response

27 May 2018

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SOD2 protects neurons from injury in cell culture and animal models of diabetic neuropathy

27 May 2018

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A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy.

27 May 2018

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Mitochondrial oxidative stress causes hyperphosphorylation of tau.

27 May 2018

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PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy.

27 May 2018

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Calorie restriction increases muscle mitochondrial biogenesis in healthy humans

27 May 2018

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Patients with type 2 diabetes have normal mitochondrial function in skeletal muscle

27 May 2018

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Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis

27 May 2018

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Resistance training, insulin sensitivity and muscle function in the elderly

27 May 2018

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Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

27 May 2018

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Effects of dietary restriction on the expression of insulin-signaling-related genes in long-lived mutant mice

27 May 2018

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Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators

27 May 2018

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PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription

27 May 2018

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Mitochondrial oxidative stress: implications for cell death

27 May 2018

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NF-Y, AP2, Nrf1 and Sp1 regulate the fragile X-related gene 2 (FXR2).

27 May 2018

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MnSOD deficiency increases endothelial dysfunction in ApoE-deficient mice

27 May 2018

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No decline in skeletal muscle oxidative capacity with aging in long-term calorically restricted rats: effects are independent of mitochondrial DNA integrity

27 May 2018

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High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

27 May 2018

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Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes.

27 May 2018

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AMPK activation increases fatty acid oxidation in skeletal muscle by activating PPARalpha and PGC-1.

27 May 2018

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Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production

27 May 2018

1 reference

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p38 Mitogen-activated protein kinase plays a stimulatory role in hepatic gluconeogenesis

27 May 2018

1 reference

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Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging

27 May 2018

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Mitochondrial transcription factor A in the maintenance of mitochondrial DNA: overview of its multiple roles

27 May 2018

1 reference

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Extension of murine life span by overexpression of catalase targeted to mitochondria

27 May 2018

1 reference

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Mitochondrial metabolism of reactive oxygen species.

27 May 2018

1 reference

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The anti-inflammatory effect of exercise

27 May 2018

1 reference

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Calorie restriction, SIRT1 and metabolism: understanding longevity

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100651

Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100651

Mitochondrial energy metabolism in heart failure: a question of balance

27 May 2018

1 reference

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PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100651

Mitochondria, oxidants, and aging

27 May 2018

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SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}

27 May 2018

1 reference

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Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins

27 May 2018

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Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice

27 May 2018

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Nuclear receptor signaling and cardiac energetics

27 May 2018

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Lack of correlation between mitochondrial reactive oxygen species production and life span in Drosophila

27 May 2018

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Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress

27 May 2018

1 reference

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p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100651

GA-binding protein transcription factor: a review of GABP as an integrator of intracellular signaling and protein-protein interactions

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100651

Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100651

Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100651

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100651

Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100651

Mitochondrial dysfunction in the elderly: possible role in insulin resistance

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100651

Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100651

Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100651

Regulation of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha ) and mitochondrial function by MEF2 and HDAC5

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100651

Topology of superoxide production from different sites in the mitochondrial electron transport chain

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100651

Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100651

Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100651

Potential health-related benefits of resistance training

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100651

Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100651

Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100651

Increased in vivo apoptosis in cells lacking mitochondrial DNA gene expression

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100651

Dietary restriction and aging in rhesus monkeys: the University of Wisconsin study.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100651

Mitochondrial free radical generation, oxidative stress, and aging

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100651

Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative disease

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100651

Ubiquitous overexpression of CuZn superoxide dismutase does not extend life span in mice

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100651

Targeted deletion of the cytosolic Cu/Zn-superoxide dismutase gene (Sod1) increases susceptibility to noise-induced hearing loss

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100651

Oxidative phosphorylation at the fin de siècle

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100651

Mitochondrial role in cell aging

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100651

The biologic clock: the mitochondria?

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100651

The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100651

Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100651

Reverse of age-dependent memory impairment and mitochondrial DNA damage in microglia by an overexpression of human mitochondrial transcription factor a in mice.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100651

Mitochondrial dysfunction as a cause of ageing

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100651

Activation of peroxisome proliferator-activated receptor pathway stimulates the mitochondrial respiratory chain and can correct deficiencies in patients' cells lacking its components

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100651

Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100651

Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100651

Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100651

p38 Mitogen-activated protein kinase mediates free fatty acid-induced gluconeogenesis in hepatocytes.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100651

PGC-1alpha gene expression is down-regulated by Akt- mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100651

Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100651

Calcineurin-NFAT signaling, together with GABP and peroxisome PGC-1{alpha}, drives utrophin gene expression at the neuromuscular junction.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100651

Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100651

Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100651

Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3100651

Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis

16 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.4061%2F2011%2F810619

Sirt1 acts in association with PPAR to protect the heart from hypertrophy, metabolic dysregulation, and inflammation

21 January 2018

1 reference

12 December 2020

Metabolic factors in the development of hepatic steatosis and altered mitochondrial gene expression in vivo

1 reference

12 December 2020

Overexpression of mitochondrial transcription factor a ameliorates mitochondrial deficiencies and cardiac failure after myocardial infarction

1 reference

12 December 2020

Increased life span due to calorie restriction in respiratory-deficient yeast

1 reference

12 December 2020

Association of age-related mitochondrial abnormalities with skeletal muscle fiber atrophy

1 reference

12 December 2020

Reduction of age-associated pathology in old mice by overexpression of catalase in mitochondria

1 reference

12 December 2020

Effects of aging on cardiac and skeletal muscle AMPK activity: basal activity, allosteric activation, and response to in vivo hypoxemia in mice

1 reference

12 December 2020

Identifiers

DOI

10.4061/2011/810619

1 reference

6 November 2017

1 reference

6 November 2017

1 reference

PMCID

3100651