Phosphoinositide 3-kinase activation regulates cell division time by coordinated control of cell mass and cell cycle progression rate (Q42802805)

7 November 2017

Phosphoinositide 3-kinase activation regulates cell division time by coordinated control of cell mass and cell cycle progression rate (English)

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7 November 2017

4

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7 November 2017

Beatriz Alvarez

1

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7 November 2017

Elia Garrido

series ordinal

2

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7 November 2017

Jose A Garcia-Sanz

series ordinal

3

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7 November 2017

language of work or name

English

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publication date

21 April 2003

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Journal of Biological Chemistry

7 November 2017

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7 November 2017

278

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7 November 2017

29

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7 November 2017

26466-26473

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Coordination of cell growth with cell division

7 November 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

G1 events and regulation of cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Kinetic analysis of regulatory events in G1 leading to proliferation or quiescence of Swiss 3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

The coupling of cell growth to the cell cycle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Why size matters: altering cell size

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Coordination of growth with cell division in the yeast Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Genetic control of cell size

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Regulation of imaginal disc cell size, cell number and organ size by Drosophila class I(A) phosphoinositide 3-kinase and its adaptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Regulation of cellular growth by the Drosophila target of rapamycin dTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Drosophila S6 kinase: a regulator of cell size

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Signaling by distinct classes of phosphoinositide 3-kinases

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M300663200

21 January 2018

Phosphoinositide kinases

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https://api.crossref.org/works/10.1074%2FJBC.M300663200

Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate: a new intracellular signalling system?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Structural and functional diversity of phosphoinositide 3-kinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

cDNA cloning of a Novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β-receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Activation of phosphatidylinositol 3-kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Direct control of the Forkhead transcription factor AFX by protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Forkhead transcription factors contribute to execution of the mitotic programme in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Akt regulates growth by directly phosphorylating Tsc2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Rapamycin induces the G0 program of transcriptional repression in yeast by interfering with the TOR signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Regulation of translation initiation by FRAP/mTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

The TOR kinases link nutrient sensing to cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Mammalian TOR: a homeostatic ATP sensor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Phosphatidic acid-mediated mitogenic activation of mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

The modular phosphorylation and activation of p70s6k.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

An encore for ribosome biogenesis in the control of cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Characterization of phosphatidylinositol 3-kinase-dependent phosphorylation of the hydrophobic motif site Thr(389) in p70 S6 kinase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Akt/protein kinase B promotes organ growth in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Phosphorylation and activation of p70s6k by PDK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Role of the PI3K regulatory subunit in the control of actin organization and cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

A new role for the p85-phosphatidylinositol 3-kinase regulatory subunit linking FRAP to p70 S6 kinase activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

The genetic control of organ growth: insights from Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

A Role for phosphoinositide 3-kinase in the control of cell division and survival during retinal development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Coupling of cell division to cell growth by translational control of the G1 cyclin CLN3 in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

PHAS-I as a link between mitogen-activated protein kinase and translation initiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

Multiple ras effector pathways contribute to G(1) cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300663200

21 January 2018

Identifiers

DOI

10.1074/JBC.M300663200

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7 November 2017

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