Impairment of methotrexate (MTX)-polyglutamate formation of MTX-resistant K562 cell lines (Q42813595)

4 July 2018

title

Impairment of methotrexate (MTX)-polyglutamate formation of MTX-resistant K562 cell lines (English)

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4 July 2018

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S Koizumi

1

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4 July 2018

publication date

1 November 1988

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4 July 2018

number of pages

8

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Japanese Journal of Cancer Research

inferred from page(s)

published in

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4 July 2018

volume

79

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4 July 2018

issue

11

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4 July 2018

page(s)

1230-1237

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4 July 2018

describes a project that uses

K562/MTX-2

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cites work

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Methotrexate-resistant Chinese hamster ovary cells contain a dihydrofolate reductase with an altered affinity for methotrexate

10 July 2018

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Establishment of methotrexate-resistant human acute lymphoblastic leukemia cells in culture and effects of folate antagonists

10 July 2018

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The pharmacology and clinical use of methotrexate

10 July 2018

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A methotrexate-resistant human breast cancer cell line with multiple defects, including diminished formation of methotrexate polyglutamates

10 July 2018

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Development of methotrexate resistance in a human squamous cell carcinoma of the head and neck in culture

10 July 2018

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Synthesis, Retention, and Biological Activity of Methotrexate Polyglutamates in Cultured Human Breast Cancer Cells

10 July 2018

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Methotrexate polyglutamate synthesis by cultured human breast cancer cells

10 July 2018

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Polygammaglutamyl metabolites of methotrexate.

10 July 2018

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Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates

10 July 2018

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Formation of methotrexate polyglutamates in purified myeloid precursor cells from normal human bone marrow

10 July 2018

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Determinants of the sensitivity of human small-cell lung cancer cell lines to methotrexate

10 July 2018

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Polyglutamation of methotrexate. Is methotrexate a prodrug?

10 July 2018

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Tissue-specific synthesis of methotrexate polyglutamates in the rat

10 July 2018

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Metaphase chromosome anomaly: association with drug resistance and cell-specific products

10 July 2018

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Synthesis of methotrexate polyglutamates in L1210 murine leukemia cells

10 July 2018

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Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells

10 July 2018

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Accumulation of methotrexate diglutamate in human liver during methotrexate therapy

10 July 2018

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Characteristics of transport of 4-amino antifolates and folate compounds by two lines of L5178Y lymphoblasts, one with impaired transport of methotrexate

10 July 2018

1 reference

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Role of thymidylate synthetase activity in development of methotrexate cytotoxicity

10 July 2018

1 reference

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A methotrexate insensitive variant of folate reductase present in two lines of methotrexate-resistant L5178Y cells

10 July 2018

1 reference

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Resistance to methotrexate in thymidylate synthetase-deficient mutants of cultured mouse mammary tumor FM3A cells.

16 August 2018

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Drug resistance in cancer

16 August 2018

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The effect of methotrexate on intracellular folate pools in human MCF-7 breast cancer cells. Evidence for direct inhibition of purine synthesis.

16 August 2018

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Enhanced inhibition of thymidylate synthase by methotrexate polyglutamates

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5917644

Thymidylate synthetase levels as a factor in 5-fluorodeoxyuridine and methotrexate cytotoxicity in gastrointestinal tumor cells

16 August 2018

1 reference

12 December 2020

Methotrexate resistance in al L1210 cell line resulting from increased dihydrofolate reductase, decreased thymidylate synthetase activity, and normal membrane transport. Computer simulations based on network thermodynamics

1 reference

12 December 2020

Relative frequency and kinetic properties of transport-defective phenotypes among methotrexate-resistant L1210 clonal cell lines derived in vivo

1 reference

12 December 2020

Differential synthesis of methotrexate polyglutamates in normal proliferative and neoplastic mouse tissues in vivo

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12 December 2020

Evidence for the cytotoxic activity of polyglutamate derivatives of methotrexate

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12 December 2020

Prolonged inhibition of DNA synthesis associated with the accumulation of methotrexate polyglutamates by cultured human cells

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12 December 2020

Acquired methotrexate resistance in lymphoblasts resulting from altered kinetic properties of dihydrofoltate reductase

1 reference

12 December 2020

Analysis of the role of membrane transport and polyglutamation of methotrexate in gut and the Ehrlich tumor in vivo as factors in drug sensitivity and selectivity

1 reference

12 December 2020

Synthesis and retention of methotrexate polyglutamates by human small cell lung cancer

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12 December 2020

10.1111/J.1349-7006.1988.TB01549.X

Identifiers

DOI

1 reference

4 July 2018

PMC publication ID

5917644

1 reference

4 July 2018

PubMed publication ID

2465288

1 reference

4 July 2018