RNAi-based functional selection identifies novel cell migration determinants dependent on PI3K and AKT pathways (Q42834164)

2 July 2019

title

RNAi-based functional selection identifies novel cell migration determinants dependent on PI3K and AKT pathways (English)

1 reference

2 July 2019

author name string

Minchul Seo

1

1 reference

2 July 2019

Shinrye Lee

2

1 reference

2 July 2019

Jong-Heon Kim

3

1 reference

2 July 2019

Won-Ha Lee

4

1 reference

2 July 2019

Guang Hu

5

1 reference

2 July 2019

Stephen J Elledge

6

1 reference

2 July 2019

Kyoungho Suk

7

1 reference

2 July 2019

language of work or name

English

0 references

publication date

28 October 2014

1 reference

2 July 2019

published in

Nature Communications

1 reference

2 July 2019

volume

5

1 reference

2 July 2019

page(s)

5217

1 reference

2 July 2019

Cell migration at a glance

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Cell migration in development and disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Immune cell migration in inflammation: present and future therapeutic targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Rap-GEF signaling controls stem cell anchoring to their niche through regulating DE-cadherin-mediated cell adhesion in the Drosophila testis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Killing the messenger: short RNAs that silence gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

A resource for large-scale RNA-interference-based screens in mammals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Identification of genes that regulate epithelial cell migration using an siRNA screening approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Modular control of endothelial sheet migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Multiparametric analysis of focal adhesion formation by RNAi-mediated gene knockdown

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

A genome-wide RNAi screen identifies multiple RSK-dependent regulators of cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Cancer proliferation gene discovery through functional genomics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Second-generation shRNA libraries covering the mouse and human genomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Genome-wide RNAi screening identifies genes inhibiting the migration of glioblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

PI3K induced actin filament remodeling through Akt and p70S6K1: implication of essential role in cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Endogenous viruses: insights into viral evolution and impact on host biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Growth factor signaling by receptor tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Phosphoinositide 3-OH kinase p85alpha and p110beta are essential for androgen receptor transactivation and tumor progression in prostate cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Strategies for silencing human disease using RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

RNA interference and human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Modulators of prostate cancer cell proliferation and viability identified by short-hairpin RNA library screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Small interfering RNA library screen identified polo-like kinase-1 (PLK1) as a potential therapeutic target for breast cancer that uniquely eliminates tumor-initiating cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Identification of FoxM1/Bub1b signaling pathway as a required component for growth and survival of rhabdomyosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Genome-scale loss-of-function screening with a lentiviral RNAi library

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

A genome-wide siRNA screen to identify modulators of insulin sensitivity and gluconeogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Functional interaction of protein kinase CK2 and c-Myc in lymphomagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Identification and functional characterization of p130Cas as a substrate of protein tyrosine phosphatase nonreceptor 14

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Muscle-specific alternative splicing of myotubularin-related 1 gene is impaired in DM1 muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Production of phosphatidylinositol 5-phosphate by the phosphoinositide 3-phosphatase myotubularin in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Targeted deletion of the calcineurin inhibitor DSCR1 suppresses tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Putative tumor suppressor Lats2 induces apoptosis through downregulation of Bcl-2 and Bcl-x(L).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Lats2, a putative tumor suppressor, inhibits G1/S transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Dynamic FoxO transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

FOXO1 inhibits Runx2 transcriptional activity and prostate cancer cell migration and invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Regulation of FOXO protein stability via ubiquitination and proteasome degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Role of PI3K and AKT specific isoforms in ovarian cancer cell migration, invasion and proliferation through the p70S6K1 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Rapamycin inhibits vascular smooth muscle cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Phosphoinositide signalling in cancer: beyond PI3K and PTEN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Five isoforms of the phosphatidylinositol 3-kinase regulatory subunit exhibit different associations with receptor tyrosine kinases and their tyrosine phosphorylations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

The emerging mechanisms of isoform-specific PI3K signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

The PI3K pathway as drug target in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

PI3K stimulates DNA synthesis and cell-cycle progression via its p55PIK regulatory subunit interaction with PCNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Blocking p55PIK signaling inhibits proliferation and induces differentiation of leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

p55PIK-PI3K stimulates angiogenesis in colorectal cancer cell by activating NF-κB pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Anaplastic lymphoma kinase (ALK): structure, oncogenic activation, and pharmacological inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Truncated ALK derived from chromosomal translocation t(2;5)(p23;q35) binds to the SH3 domain of p85-PI3K.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Anaplastic lymphoma kinase (ALK)-induced malignancies: novel mechanisms of cell transformation and potential therapeutic approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Anaplastic lymphoma kinase: signalling in development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Anaplastic lymphoma kinase is required for neurogenesis in the developing central nervous system of zebrafish

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Identification of novel cell migration-promoting genes by a functional genetic screen

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

HMGB1 as an autocrine stimulus in human T98G glioblastoma cells: role in cell growth and migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6217

Protein kinase CK2 promotes aberrant activation of nuclear factor-kappaB, transformed phenotype, and survival of breast cancer cells.

21 January 2018

1 reference

12 December 2020

Overexpression of the N-terminal end of the p55gamma regulatory subunit of phosphatidylinositol 3-kinase blocks cell cycle progression in gastric carcinoma cells.

1 reference

12 December 2020

Analysis of cell migration using whole-genome expression profiling of migratory cells in the Drosophila ovary

1 reference

12 December 2020

A systematic RNA interference screen reveals a cell migration gene network in C. elegans

1 reference

12 December 2020

Integrative genomic analysis of phosphatidylinositol 3'-kinase family identifies PIK3R3 as a potential therapeutic target in epithelial ovarian cancer

1 reference

12 December 2020

The neurodevelopmental implications of PI3K signaling

1 reference

12 December 2020

Casein kinase II is elevated in solid human tumours and rapidly proliferating non-neoplastic tissue

1 reference

12 December 2020

The functions and regulation of the PTEN tumour suppressor

1 reference

12 December 2020

Using functional genomics to overcome therapeutic resistance in hematological malignancies.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCOMMS6217

1 reference

2 July 2019

release_wrpmafhdtnf5dlhc4bp5lk6i3a

ADS bibcode

2014NatCo...5.5217S

0 references

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/wrpmafhdtnf5dlhc4bp5lk6i3a

24 November 2022

mapped directly with Wikidata item

PMC publication ID

6581447

1 reference

2 July 2019

PubMed publication ID

25347953

1 reference

2 July 2019