GPI-1046 Increases Presenilin-1 Expression and Restores NMDA Channel Activity (Q42931990)

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10 February 2020

title

GPI-1046 increases presenilin-1 expression and restores NMDA channel activity (English)

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10 February 2020

GPI-1046 Increases Presenilin-1 Expression and Restores NMDA Channel Activity (English)

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19 June 2024

author name string

Christopher Drummond Main

3

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10 February 2020

Sabrina D'Alfonso

4

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10 February 2020

Joseph P. Steiner

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19 June 2024

Kathryn B. Payne

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19 June 2024

Kirsten X. Jacobsen

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19 June 2024

T. Philip Hicks

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19 June 2024

William A. Staines

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19 June 2024

Michael O. Poulter

8

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19 June 2024

language of work or name

English

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National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=20724252

19 June 2024

publication date

1 July 2010

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full work available at URL

10 February 2020

https://www.cambridge.org/core/services/aop-cambridge-core/content/view/064C47AD04D27A731C35AC265BDED456/S0317167100010465a.pdf/div-class-title-gpi-1046-increases-presenilin-1-expression-and-restores-nmda-channel-activity-div.pdf

file format

Portable Document Format

online access status

open access

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19 June 2024

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Canadian Journal of Neurological Sciences

19 June 2024

published in

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10 February 2020

volume

37

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10 February 2020

issue

4

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10 February 2020

page(s)

457-467

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The small molecule FKBP ligand GPI 1046 induces partial striatal re-innervation after intranigral 6-hydroxydopamine lesion in rats

10 February 2020

cites work

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100010465

7 January 2021

CONREAL web server: identification and visualization of conserved transcription factor binding sites

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100010465

7 January 2021

Overexpression of wild type but not an FAD mutant presenilin-1 promotes neurogenesis in the hippocampus of adult mice

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100010465

7 January 2021

Systemic treatment with GPI 1046 improves spatial memory and reverses cholinergic neuron atrophy in the medial septal nucleus of aged mice

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100010465

7 January 2021

Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100010465

7 January 2021

Abnormal synaptic plasticity in the striatum of mice lacking dopamine D2 receptors

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100010465

7 January 2021

FK506 binding protein 12 is expressed in rat penile innervation and upregulated after cavernous nerve injury

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100010465

7 January 2021

A novel mutation (G217D) in the Presenilin 1 gene ( PSEN1) in a Japanese family: presenile dementia and parkinsonism are associated with cotton wool plaques in the cortex and striatum

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100010465

7 January 2021

Overexpression in neurons of human presenilin-1 or a presenilin-1 familial Alzheimer disease mutant does not enhance apoptosis.

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100010465

7 January 2021

The immunophilin ligand FK506 attenuates the axonal damage associated with rapid rewarming following posttraumatic hypothermia

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100010465

7 January 2021

Lesion of the substantia nigra pars compacta downregulates striatal glutamate receptor subunit mRNA expression

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100010465

7 January 2021

Tacrolimus (FK506) down-regulates free radical tissue levels, serum cytokines, and neutrophil infiltration after severe liver ischemia

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100010465

7 January 2021

Under siege: The brain on opiates

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100010465

7 January 2021

Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100010465

7 January 2021

Oral administration of a nonimmunosuppressant FKBP-12 ligand speeds nerve regeneration

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100010465

7 January 2021

Spontaneous axonal regeneration after optic nerve injury in adult rat.

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100010465

7 January 2021

Mice lacking both presenilin genes exhibit early embryonic patterning defects

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100010465

7 January 2021

Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2.

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100010465

7 January 2021

Dopamine and cAMP-regulated phosphoprotein 32 kDa controls both striatal long-term depression and long-term potentiation, opposing forms of synaptic plasticity

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100010465

7 January 2021

Neuroimmunophilins: a novel drug therapy for the reversal of neurodegenerative disease?

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100010465

7 January 2021

Divergent GABA(A) receptor-mediated synaptic transmission in genetically seizure-prone and seizure-resistant rats.

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100010465

7 January 2021

In situ hybridization analysis of presenilin 1 mRNA in Alzheimer disease and in lesioned rat brain

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100010465

7 January 2021

Bcl-2 regulator FKBP38 is activated by Ca2+/calmodulin

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100010465

7 January 2021

Immunosuppressants decrease neutrophil chemoattractant and attenuate ischemia/reperfusion injury of the liver in rats

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100010465

7 January 2021

The protective effect of FK506 pretreatment against renal ischemia/reperfusion injury in rats

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100010465

7 January 2021

cAMP-dependent protein kinase mediates activity-regulated synaptic targeting of NMDA receptors.

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100010465

7 January 2021

Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100010465

7 January 2021

The effects of FK506 on dorsal column axons following spinal cord injury in adult rats: neuroprotection and local regeneration.

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100010465

7 January 2021

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100010465

7 January 2021

CONREAL: conserved regulatory elements anchored alignment algorithm for identification of transcription factor binding sites by phylogenetic footprinting

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100010465

7 January 2021

Regeneration of dopaminergic function in 6-hydroxydopamine-lesioned rats by neuroimmunophilin ligand treatment.

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100010465

7 January 2021

Gene expression of glutamate receptors GluR1 and NR1 is differentially modulated in striatal neurons in rats after 6-hydroxydopamine lesion

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100010465

7 January 2021

Static, transient and permanent organization of GABA receptor expression in calbindin-positive interneurons in response to amygdala kindled seizures

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100010465

7 January 2021

Addiction, dopamine, and the molecular mechanisms of memory

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100010465

7 January 2021

Presenilins in memory, Alzheimer's disease, and therapy

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100010465

7 January 2021

Presenilins are essential for regulating neurotransmitter release

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100010465

7 January 2021

Immunophilin ligand FK506 is neuroprotective for penile innervation

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100010465

7 January 2021

Identification of the role of presenilins beyond Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100010465

7 January 2021

Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100010465

7 January 2021

Protective Effect of FK506 on Ischemia/Reperfusion-Induced Myocardial Damage in Canine Heart

1 reference

https://api.crossref.org/works/10.1017%2FS0317167100010465

7 January 2021

Subcellular segregation of distinct heteromeric NMDA glutamate receptors in the striatum

12

1 reference

https://api.crossref.org/works/10.1017/S0317167100010465

Effects of presenilins and beta-amyloid precursor protein on delayed rectifier potassium channels in cultured rat hippocampal neurons

19 June 2024

38

1 reference

https://api.crossref.org/works/10.1017/S0317167100010465

19 June 2024

Identifiers

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10 February 2020

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