Discrete signaling pathways participate in RB-dependent responses to chemotherapeutic agents (Q44830479)

6 December 2017

Discrete signaling pathways participate in RB-dependent responses to chemotherapeutic agents (English)

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6 December 2017

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4

Julien Sage

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6 December 2017

5

Tyler Jacks

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6 December 2017

Christopher N Mayhew

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6 December 2017

Lisa M Perkin

series ordinal

2

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6 December 2017

Xiaoping Zhang

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3

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6 December 2017

Erik S Knudsen

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6

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6 December 2017

language of work or name

English

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publication date

1 May 2004

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6 December 2017

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6 December 2017

23

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6 December 2017

4107-4120

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6 December 2017

23

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1207503

6 December 2017

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Retinoblastoma tumor suppressor targets dNTP metabolism to regulate DNA replication

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Post-translational modifications and activation of p53 by genotoxic stresses

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Active Localization of the Retinoblastoma Protein in Chromatin and Its Response to S Phase DNA Damage

21 January 2018

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Recapitulation of the effects of the human papillomavirus type 16 E7 oncogene on mouse epithelium by somatic Rb deletion and detection of pRb-independent effects of E7 in vivo

21 January 2018

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Novel aspects of resistance to drugs targeted to dihydrofolate reductase and thymidylate synthase

21 January 2018

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Enhanced phosphorylation of p53 by ATM in response to DNA damage

21 January 2018

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Mammalian G1- and S-phase checkpoints in response to DNA damage

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ATM is a target for positive regulation by E2F-1.

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Radiation-induced cell cycle arrest compromised by p21 deficiency

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Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after gamma-irradiation

21 January 2018

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Disruption of p53 in human cancer cells alters the responses to therapeutic agents

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Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

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Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes

21 January 2018

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Growth arrest by induction of p53 in DNA damaged keratinocytes is bypassed by human papillomavirus 16 E7.

21 January 2018

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Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

21 January 2018

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The regulation of E2F by pRB-family proteins

21 January 2018

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WAF1, a potential mediator of p53 tumor suppression

21 January 2018

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Mechanisms of cell-cycle checkpoints: at the crossroads of carcinogenesis and drug discovery

21 January 2018

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A novel DNA damage checkpoint involving post-transcriptional regulation of cyclin A expression

21 January 2018

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Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer

21 January 2018

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Rb function in cell-cycle regulation and apoptosis

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Abnormalities in structure and expression of the human retinoblastoma gene in SCLC.

21 January 2018

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Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1

21 January 2018

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pRB plays an essential role in cell cycle arrest induced by DNA damage

21 January 2018

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Checkpoints: controls that ensure the order of cell cycle events

21 January 2018

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p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts

21 January 2018

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Mechanisms by which DNA tumor virus oncoproteins target the Rb family of pocket proteins

21 January 2018

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Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts

21 January 2018

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Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells

21 January 2018

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pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.

21 January 2018

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Effects of an Rb mutation in the mouse

21 January 2018

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A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

21 January 2018

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Inhibition of DNA synthesis by RB: effects on G1/S transition and S-phase progression

21 January 2018

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RB-dependent S-phase response to DNA damage

21 January 2018

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Cyclin A is a functional target of retinoblastoma tumor suppressor protein-mediated cell cycle arrest

21 January 2018

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Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation

21 January 2018

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DP and E2F proteins: coordinating transcription with cell cycle progression.

21 January 2018

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DNA damage invokes mismatch repair-dependent cyclin D1 attenuation and retinoblastoma signaling pathways to inhibit CDK2.

21 January 2018

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Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

21 January 2018

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Inactivation of the retinoblastoma susceptibility gene in human breast cancers

21 January 2018

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Functional inactivation of pRB results in aneuploid mammalian cells after release from a mitotic block

21 January 2018

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Lack of functional retinoblastoma protein mediates increased resistance to antimetabolites in human sarcoma cell lines.

21 January 2018

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5-Fluorouracil: mechanisms of action and clinical strategies

21 January 2018

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Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes

21 January 2018

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Conditional mutation of Rb causes cell cycle defects without apoptosis in the central nervous system

21 January 2018

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Rapid destruction of human Cdc25A in response to DNA damage

21 January 2018

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Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A.

21 January 2018

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Control of pRB phosphorylation

21 January 2018

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Coordinated trans activation of DNA synthesis- and precursor-producing enzymes by polyomavirus large T antigen through interaction with the retinoblastoma protein

21 January 2018

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E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis.

21 January 2018

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Toward maintaining the genome: DNA damage and replication checkpoints

21 January 2018

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Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism

21 January 2018

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E2Fs up-regulate expression of genes involved in DNA replication, DNA repair and mitosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207503

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207503

E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207503

Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207503

Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207503

Histone Deacetylation of RB-Responsive Promoters: Requisite for Specific Gene Repression but Dispensable for Cell Cycle Inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207503

p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207503

Role of retinoblastoma gene product in p53-mediated DNA damage response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207503

Purification and amino acid analysis of an active site peptide from thymidylate synthetase containing covalently bound 5-fluoro-2'-deoxyuridylate and methylenetetrahydrofolate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207503

Human papillomavirus type 16 E6 and E7 oncogenes abrogate radiation-induced DNA damage responses in vivo through p53-dependent and p53-independent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207503

p53 Signaling and cell cycle checkpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207503

Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207503

The retinoblastoma protein and cell cycle control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207503

Rb-mediated chromatin structure regulation and transcriptional repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207503

Retinoblastoma tumor suppressor and genome stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207503

Distinct Initiation and Maintenance Mechanisms Cooperate to Induce G1 Cell Cycle Arrest in Response to DNA Damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207503

Aberrations of the G1- and G1/S-regulating genes in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207503

7 January 2021

Requirement for a functional Rb-1 gene in murine development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207503

7 January 2021

A binding site for transcription factor E2F is a target for trans activation of murine thymidine kinase by polyomavirus large T antigen and plays an important role in growth regulation of the gene.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207503

7 January 2021

The retinoblastoma protein is essential for cyclin A repression in quiescent cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207503

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1207503

1 reference

6 December 2017

1 reference