Lysine residues in the N-terminal huntingtin amphipathic α-helix play a key role in peptide aggregation (Q45008320)

8 December 2017

title

Lysine residues in the N-terminal huntingtin amphipathic α-helix play a key role in peptide aggregation (English)

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8 December 2017

James R Arndt

1

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8 December 2017

Robert J Brown

2

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8 December 2017

Kathleen A Burke

3

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8 December 2017

Justin Legleiter

4

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8 December 2017

Stephen J Valentine

5

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8 December 2017

publication date

1 January 2015

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Journal of Mass Spectrometry

8 December 2017

published in

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8 December 2017

volume

50

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8 December 2017

issue

1

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8 December 2017

page(s)

117-126

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

8 December 2017

cites work

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Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

21 January 2018

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CAG repeat number governs the development rate of pathology in Huntington's disease

21 January 2018

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Slow amyloid nucleation via α-helix-rich oligomeric intermediates in short polyglutamine-containing huntingtin fragments.

21 January 2018

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Secondary structures of native and pathogenic huntingtin N-terminal fragments.

21 January 2018

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Inhibiting the nucleation of amyloid structure in a huntingtin fragment by targeting α-helix-rich oligomeric intermediates

21 January 2018

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Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity

21 January 2018

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The aggregation-enhancing huntingtin N-terminus is helical in amyloid fibrils

21 January 2018

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The predicted structure of the headpiece of the Huntingtin protein and its implications on Huntingtin aggregation

21 January 2018

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Secondary Structure of Huntingtin Amino-Terminal Region

21 January 2018

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Membrane interactions of the amphipathic amino terminus of huntingtin

21 January 2018

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Conformations of the Huntingtin N-term in aqueous solution from atomistic simulations.

21 January 2018

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Identification of novel potentially toxic oligomers formed in vitro from mammalian-derived expanded huntingtin exon-1 protein

21 January 2018

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The interaction of polyglutamine peptides with lipid membranes is regulated by flanking sequences associated with huntingtin

21 January 2018

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Huntingtin disrupts lipid bilayers in a polyQ-length dependent manner

21 January 2018

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The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation

21 January 2018

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Structural features and domain organization of huntingtin fibrils

21 January 2018

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Kinetically competing huntingtin aggregation pathways control amyloid polymorphism and properties

21 January 2018

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Mutant huntingtin fragments form oligomers in a polyglutamine length-dependent manner in vitro and in vivo

21 January 2018

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Modulation of polyglutamine conformations and dimer formation by the N-terminus of huntingtin

21 January 2018

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Serine phosphorylation suppresses huntingtin amyloid accumulation by altering protein aggregation properties.

21 January 2018

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Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice

21 January 2018

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Kinase inhibitors modulate huntingtin cell localization and toxicity.

21 January 2018

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Network organization of the huntingtin proteomic interactome in mammalian brain

21 January 2018

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β-hairpin-mediated nucleation of polyglutamine amyloid formation.

21 January 2018

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Structural characterization of polyglutamine fibrils by solid-state NMR spectroscopy

21 January 2018

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Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism

21 January 2018

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Tracking mutant huntingtin aggregation kinetics in cells reveals three major populations that include an invariant oligomer pool.

21 January 2018

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Partial cooperative unfolding in proteins as observed by hydrogen exchange mass spectrometry

21 January 2018

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Automated hydrogen/deuterium exchange electron transfer dissociation high resolution mass spectrometry measured at single-amide resolution

21 January 2018

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Structure and dynamics of small soluble Aβ(1-40) oligomers studied by top-down hydrogen exchange mass spectrometry

21 January 2018

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Platform dependencies in bottom-up hydrogen/deuterium exchange mass spectrometry

21 January 2018

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Surrogate H/D detection strategy for protein conformational analysis using MS/MS data

21 January 2018

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Pepsin immobilized on high-strength hybrid particles for continuous flow online digestion at 10,000 psi.

21 January 2018

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Conformational transitions in the membrane scaffold protein of phospholipid bilayer nanodiscs

21 January 2018

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Hydrogen/deuterium exchange and electron-transfer dissociation mass spectrometry determine the interface and dynamics of apolipoprotein E oligomerization

21 January 2018

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Application of the ETD/PTR reactions in top-down proteomics as a faster alternative to bottom-up nanoLC-MS/MS protein identification

21 January 2018

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Structural insights into the pre-amyloid tetramer of β-2-microglobulin from covalent labeling and mass spectrometry

21 January 2018

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Structure of the preamyloid dimer of beta-2-microglobulin from covalent labeling and mass spectrometry

21 January 2018

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Structural analysis of intact monoclonal antibodies by electron transfer dissociation mass spectrometry

21 January 2018

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Characterizing short-lived protein folding intermediates by top-down hydrogen exchange mass spectrometry

21 January 2018

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Hydrogen/deuterium exchange mass spectrometry with top-down electron capture dissociation for characterizing structural transitions of a 17 kDa protein

21 January 2018

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Throughput and efficiency of a mass spectrometry-based screening assay for protein-ligand binding detection

21 January 2018

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Conformer-specific hydrogen exchange analysis of Aβ(1-42) oligomers by top-down electron capture dissociation mass spectrometry.

21 January 2018

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Abeta(1-40) forms five distinct amyloid structures whose beta-sheet contents and fibril stabilities are correlated

21 January 2018

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Beta-sheet core of human prion protein amyloid fibrils as determined by hydrogen/deuterium exchange

21 January 2018

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Conformational transition occurring upon amyloid aggregation of the HET-s prion protein of Podospora anserina analyzed by hydrogen/deuterium exchange and mass spectrometry

21 January 2018

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Aggregation behavior of chemically synthesized, full-length huntingtin exon1.

21 January 2018

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Solubilization and disaggregation of polyglutamine peptides

21 January 2018

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Assessing mutant huntingtin fragment and polyglutamine aggregation by atomic force microscopy

21 January 2018

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pH-Dependent Amyloid and Protofibril Formation by the ABri Peptide of Familial British Dementia

21 January 2018

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Assessing the contribution of heterogeneous distributions of oligomers to aggregation mechanisms of polyglutamine peptides

21 January 2018

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Electron transfer ion/ion reactions in a three-dimensional quadrupole ion trap: reactions of doubly and triply protonated peptides with SO2*-

21 January 2018

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Ion/ion chemistry of high-mass multiply charged ions

21 January 2018

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Peptide and protein sequence analysis by electron transfer dissociation mass spectrometry

21 January 2018

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Glutamine repeats as polar zippers: their possible role in inherited neurodegenerative diseases

21 January 2018

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Structure of the cross-beta spine of amyloid-like fibrils

21 January 2018

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Structure and Topology of the Huntingtin 1–17 Membrane Anchor by a Combined Solution and Solid-State NMR Approach

21 January 2018

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A stress sensitive ER membrane-association domain in Huntingtin protein defines a potential role for Huntingtin in the regulation of autophagy

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JMS.3504

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8 December 2017

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