PI3K/mTOR inhibition upregulates NOTCH-MYC signalling leading to an impaired cytotoxic response (Q45038180)

8 December 2017

PI3K/mTOR inhibition upregulates NOTCH-MYC signalling leading to an impaired cytotoxic response (English)

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8 December 2017

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R E Gale

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C Shepherd

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L Banerjee

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C W Cheung

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M R Mansour

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S Jenkinson

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A Khwaja

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5 October 2012

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27

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650-660

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https://scigraph.springernature.com/pub.10.1038/leu.2012.285

8 December 2017

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c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma

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NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth

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Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells

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21 January 2018

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Repression of tumor suppressor miR-451 is essential for NOTCH1-induced oncogenesis in T-ALL.

21 January 2018

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Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation

21 January 2018

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Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia.

21 January 2018

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PI3K-targeted therapy can be evaded by gene amplification along the MYC-eukaryotic translation initiation factor 4E (eIF4E) axis

21 January 2018

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Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway-dependent and PI3K pathway-independent mechanisms

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2012.285

A chemical-genetic screen reveals a mechanism of resistance to PI3K inhibitors in cancer.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2012.285

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2012.285

Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2012.285

Notch-1 mutations are secondary events in some patients with T-cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.285

inferred from DOI database lookup

7 January 2021

based on heuristic

High incidence of Notch-1 mutations in adult patients with T-cell acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.285

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/LEU.2012.285

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Dimensions Publication ID

8 December 2017

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