Cholesterol accumulation and diabetes in pancreatic beta-cell-specific SREBP-2 transgenic mice: a new model for lipotoxicity (Q46444249)

22 December 2017

title

Cholesterol accumulation and diabetes in pancreatic beta-cell-specific SREBP-2 transgenic mice: a new model for lipotoxicity (English)

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22 December 2017

author

Naoya Yahagi

10

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22 December 2017

author name string

Mayumi Ishikawa

1

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22 December 2017

Yuko Iwasaki

2

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22 December 2017

Shigeru Yatoh

3

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22 December 2017

Toyonori Kato

4

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22 December 2017

Shin Kumadaki

5

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22 December 2017

Noriyuki Inoue

6

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22 December 2017

Takashi Yamamoto

7

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22 December 2017

Takashi Matsuzaka

8

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22 December 2017

Yoshimi Nakagawa

9

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22 December 2017

Kazuto Kobayashi

11

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22 December 2017

Akimitsu Takahashi

12

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22 December 2017

Nobuhiro Yamada

13

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22 December 2017

Hitoshi Shimano

14

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22 December 2017

language of work or name

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5 August 2008

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22 December 2017

Journal of Lipid Research

published in

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22 December 2017

volume

49

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22 December 2017

issue

12

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22 December 2017

page(s)

2524-2534

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22 December 2017

Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications.

cites work

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https://api.crossref.org/works/10.1194%2FJLR.M800238-JLR200

Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M800238-JLR200

Sterol regulatory element-binding protein family as global regulators of lipid synthetic genes in energy metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M800238-JLR200

Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M800238-JLR200

Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M800238-JLR200

Sterol regulatory element-binding protein-1c and pancreatic beta-cell dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M800238-JLR200

SREBPs suppress IRS-2-mediated insulin signalling in the liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M800238-JLR200

Transgenic mice overexpressing nuclear SREBP-1c in pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M800238-JLR200

Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M800238-JLR200

Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M800238-JLR200

The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M800238-JLR200

A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M800238-JLR200

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M800238-JLR200

SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M800238-JLR200

Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M800238-JLR200

Sterol regulatory element-binding proteins activate insulin gene promoter directly and indirectly through synergy with BETA2/E47.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M800238-JLR200

Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M800238-JLR200

Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M800238-JLR200

Increased islet apoptosis in Pdx1+/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M800238-JLR200

Disruption of IRS-2 causes type 2 diabetes in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M800238-JLR200

Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M800238-JLR200

Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M800238-JLR200

Uncoupling protein 2: a possible link between fatty acid excess and impaired glucose-induced insulin secretion?

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M800238-JLR200

Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M800238-JLR200

Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M800238-JLR200

Distinct effects of pravastatin, atorvastatin, and simvastatin on insulin secretion from a beta-cell line, MIN6 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M800238-JLR200

Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M800238-JLR200

Cholesterol in islet dysfunction and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M800238-JLR200

10.1194/JLR.M800238-JLR200

21 January 2018

Identifiers

DOI

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22 December 2017

PubMed ID

18682608

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22 December 2017