E2F1 suppresses skin carcinogenesis via the ARF-p53 pathway (Q46736501)

24 December 2017

title

E2F1 suppresses skin carcinogenesis via the ARF-p53 pathway (English)

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24 December 2017

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Russell JL

1

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24 December 2017

Weaks RL

series ordinal

2

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24 December 2017

Berton TR

series ordinal

3

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24 December 2017

Johnson DG

series ordinal

4

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24 December 2017

language of work or name

English

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publication date

1 February 2006

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24 December 2017

published in

Oncogene

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24 December 2017

volume

25

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24 December 2017

issue

6

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24 December 2017

page(s)

867-876

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24 December 2017

mdm2 expression is induced by wild type p53 activity

cites work

1 reference

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7 January 2021

p14ARF links the tumour suppressors RB and p53.

1 reference

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7 January 2021

Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53

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7 January 2021

Dual functions of E2F-1 in a transgenic mouse model of liver carcinogenesis

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7 January 2021

E1A signaling to p53 involves the p19(ARF) tumor suppressor

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7 January 2021

Distinct roles for E2F proteins in cell growth control and apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland

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7 January 2021

Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

Human ARF binds E2F1 and inhibits its transcriptional activity.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

Characterization of an inbred strain of the SENCAR mouse that is highly sensitive to phorbol esters.

1 reference

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7 January 2021

Transcription factor E2F-1 acts as a growth-promoting factor and is associated with adverse prognosis in non-small cell lung carcinomas

1 reference

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7 January 2021

Role for the p53 homologue p73 in E2F-1-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

Oncogenic capacity of the E2F1 gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

Expression of transcription factor E2F1 induces quiescent cells to enter S phase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

v-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: effects of phorbol esters and retinoic acid

1 reference

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7 January 2021

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

1 reference

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7 January 2021

Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation

1 reference

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7 January 2021

p19ARF targets certain E2F species for degradation.

1 reference

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7 January 2021

The absence of p21Cip1/WAF1 alters keratinocyte growth and differentiation and promotes ras-tumor progression.

1 reference

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7 January 2021

Apaf-1 is a transcriptional target for E2F and p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

Direct coupling of the cell cycle and cell death machinery by E2F.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

p19ARF links the tumour suppressor p53 to Ras

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

The ink4a/arf tumor suppressors cooperate with p21cip1/waf in the processes of mouse epidermal differentiation, senescence, and carcinogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

Deregulated expression of E2F1 induces hyperplasia and cooperates with ras in skin tumor development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

Increased E2F1 activity induces skin tumors in mice heterozygous and nullizygous for p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

E2F1 has both oncogenic and tumor-suppressive properties in a transgenic model

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

Signaling to p53: breaking the MDM2-p53 circuit

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

Sequences 5' of the bovine keratin 5 gene direct tissue- and cell-type-specific expression of a lacZ gene in the adult and during development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

Localization of phosphorylated forms of Bcl-2 in mitosis: co-localization with Ki-67 and nucleolin in nuclear structures and on mitotic chromosomes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

E2F1 induces phosphorylation of p53 that is coincident with p53 accumulation and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

Apoptosis associated with deregulated E2F activity is dependent on E2F1 and Atm/Nbs1/Chk2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

Myc lacks E2F1's ability to suppress skin carcinogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

ARF differentially modulates apoptosis induced by E2F1 and Myc.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

Amplification of the E2F1 transcription factor gene in the HEL erythroleukemia cell line

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetate-type tumor promoter

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

p19(ARF) is dispensable for oncogenic stress-induced p53-mediated apoptosis and tumor suppression in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

ARF is not required for apoptosis in Rb mutant mouse embryos

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

Role for the double-stranded RNA activated protein kinase PKR in E2F-1-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

Deregulated expression of DP1 induces epidermal proliferation and enhances skin carcinogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

E2F4 and E2F1 have similar proliferative properties but different apoptotic and oncogenic properties in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

Role of p14(ARF) in replicative and induced senescence of human fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

The p53-mdm-2 autoregulatory feedback loop

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

p53 and E2F-1 cooperate to mediate apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

Multiple members of the E2F transcription factor family are the products of oncogenes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

Tumor induction and tissue atrophy in mice lacking E2F-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

The pathogenesis of squamous cell cancer: lessons learned from studies of skin carcinogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

E2F1 and E2F2 determine thresholds for antigen-induced T-cell proliferation and suppress tumorigenesis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

Sunburn and p53 in the onset of skin cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209120

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1209120

1 reference

24 December 2017

Dimensions Publication ID

1047078528

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1 reference

24 December 2017