The target landscape of clinical kinase drugs (Q47345032)

http://europepmc.org/abstract/PMC/6542668

1 July 2019

title

The target landscape of clinical kinase drugs (English)

1 reference

http://europepmc.org/abstract/PMC/6542668

1 July 2019

author

Bjoern Gohlke

27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29191878%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Florian Bassermann

36

1 reference

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11 June 2020

Jürgen Ruland

44

1 reference

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11 June 2020

Irmela Jeremias

46

1 reference

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11 June 2020

Susan Klaeger

1

1 reference

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11 June 2020

Stephanie Heinzlmeir

2

1 reference

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11 June 2020

Mathias Wilhelm

3

1 reference

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11 June 2020

Binje Vick

5

1 reference

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11 June 2020

Paul A Koenig

6

1 reference

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11 June 2020

Svenja Petzoldt

9

1 reference

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11 June 2020

Katrin Reiter

12

1 reference

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11 June 2020

Dominic Helm

14

1 reference

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11 June 2020

Zhixiang Wu

21

1 reference

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11 June 2020

Tobias Schmidt

22

1 reference

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11 June 2020

Wilhelm Becker

24

1 reference

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11 June 2020

Daniel Paul Zolg

28

1 reference

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11 June 2020

Gian Kayser

29

1 reference

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11 June 2020

Tonu Vooder

30

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11 June 2020

Robert Preissner

31

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11 June 2020

Neeme Tõnisson

33

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11 June 2020

Judith Schlegl

37

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11 June 2020

Hans-Christian Ehrlich

38

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11 June 2020

Stephan Aiche

39

1 reference

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11 June 2020

Philipp A Greif

41

1 reference

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11 June 2020

Sabine Schneider

42

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11 June 2020

Eduard Rudolf Felder

43

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11 June 2020

Guillaume Médard

45

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11 June 2020

Karsten Spiekermann

47

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11 June 2020

Bernhard Kuster

48

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11 June 2020

author name string

Harald Polzer

4

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11 June 2020

Maria Reinecke

7

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11 June 2020

Benjamin Ruprecht

8

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11 June 2020

Chen Meng

10

1 reference

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11 June 2020

Huichao Qiao

13

1 reference

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11 June 2020

Heiner Koch

15

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11 June 2020

Melanie Schoof

16

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11 June 2020

Giulia Canevari

17

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11 June 2020

Elena Casale

18

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11 June 2020

Stefania Re Depaolini

19

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11 June 2020

Annette Feuchtinger

20

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11 June 2020

Lars Rueckert

23

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11 June 2020

Jan Huenges

25

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11 June 2020

Anne-Kathrin Garz

26

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11 June 2020

Hannes Hahne

32

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11 June 2020

Karl Kramer

34

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11 June 2020

Katharina Götze

35

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11 June 2020

Axel Walch

40

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11 June 2020

Jana Zecha

11

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11 June 2020

language of work or name

English

0 references

publication date

1 December 2017

1 reference

http://europepmc.org/abstract/PMC/6542668

1 July 2019

published in

Science

1 reference

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11 June 2020

volume

358

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11 June 2020

issue

6367

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describes a project that uses

11 June 2020

Cytoscape

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9 June 2022

https://europepmc.org/search?query=(METHODS:'Cytoscape')

based on heuristic

inferred from PubMed Central ID database lookup

cites work

FDA-approved small-molecule kinase inhibitors.

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Ten things you should know about protein kinases: IUPHAR Review 14

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

A quantitative analysis of kinase inhibitor selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Comprehensive analysis of kinase inhibitor selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

The selectivity of protein kinase inhibitors: a further update

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

A small molecule-kinase interaction map for clinical kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Comprehensive characterization of the Published Kinase Inhibitor Set

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

21 January 2018

Navigating the kinome

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Optimized chemical proteomics assay for kinase inhibitor profiling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Mass-spectrometry-based draft of the human proteome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

In situ kinase profiling reveals functionally relevant properties of native kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

What general conclusions can we draw from kinase profiling data sets?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

A comparison of protein kinases inhibitor screening methods using both enzymatic activity and binding affinity determination

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Gini coefficient: a new way to express selectivity of kinase inhibitors against a family of kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

A theoretical entropy score as a single value to express inhibitor selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Analysis of kinase inhibitor selectivity using a thermodynamics-based partition index

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

A public-private partnership to unlock the untargeted kinome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

KLIFS: a structural kinase-ligand interaction database

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Exploration of type II binding mode: A privileged approach for kinase inhibitor focused drug discovery?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

The ChEMBL bioactivity database: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

The clinically approved drugs dasatinib and bosutinib induce anti-inflammatory macrophages by inhibiting the salt-inducible kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Exploiting polypharmacology for drug target deconvolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Parallel reaction monitoring for high resolution and high mass accuracy quantitative, targeted proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Targeted proteomic quantification on quadrupole-orbitrap mass spectrometer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

The TPM3-NTRK1 rearrangement is a recurring event in colorectal carcinoma and is associated with tumor sensitivity to TRKA kinase inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Crystal structure of pyridoxal kinase in complex with roscovitine and derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Chemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Tracking cancer drugs in living cells by thermal profiling of the proteome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Protein kinase CK2 potentiates translation efficiency by phosphorylating eIF3j at Ser127.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Phosphoproteome Profiling Reveals Molecular Mechanisms of Growth-Factor-Mediated Kinase Inhibitor Resistance in EGFR-Overexpressing Cancer Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Proteogenomics connects somatic mutations to signalling in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Network-based approach identified cell cycle genes as predictor of overall survival in lung adenocarcinoma patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

CRISPR/Cas9 mutagenesis invalidates a putative cancer dependency targeted in on-going clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

MELK is not necessary for the proliferation of basal-like breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Cabozantinib is selectively cytotoxic in acute myeloid leukemia cells with FLT3-internal tandem duplication (FLT3-ITD).

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

DMSO enhances electrospray response, boosting sensitivity of proteomic experiments

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Andromeda: a peptide search engine integrated into the MaxQuant environment

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Accurate proteome-wide label-free quantification by delayed normalization and maximal peptide ratio extraction, termed MaxLFQ.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Dose-Response Analysis Using R.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Comparing immobilized kinase inhibitors and covalent ATP probes for proteomic profiling of kinase expression and drug selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Integrative genomics viewer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Comprehensive and reproducible phosphopeptide enrichment using iron immobilized metal ion affinity chromatography (Fe-IMAC) columns

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Skyline: an open source document editor for creating and analyzing targeted proteomics experiments

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Global proteome analysis of the NCI-60 cell line panel

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Integration, scaling, space-group assignment and post-refinement

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Better models by discarding data?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Linking Crystallographic Model and Data Quality

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Overview of the CCP4 suite and current developments

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Refinement of macromolecular structures by the maximum-likelihood method

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

REFMAC5 for the refinement of macromolecular crystal structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Features and development of Coot

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Structural insight into maternal embryonic leucine zipper kinase (MELK) conformation and inhibition toward structure-based drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

iMOSFLM: a new graphical interface for diffraction-image processing with MOSFLM

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Scaling and assessment of data quality

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Phasercrystallographic software

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Universal sample preparation method for proteome analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

The Perseus computational platform for comprehensive analysis of (prote)omics data

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

STRING v10: protein-protein interaction networks, integrated over the tree of life

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Systematic identification of the HSP90 candidate regulated proteome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Early recognition of lung cancer by integrin targeted imaging in K-ras mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Simultaneous multi-antibody staining in non-small cell lung cancer strengthens diagnostic accuracy especially in small tissue samples

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Casitas B-lineage lymphoma mutants activate AKT to induce transformation in cooperation with class III receptor tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Activating FLT3 mutants show distinct gain-of-function phenotypes in vitro and a characteristic signaling pathway profile associated with prognosis in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Visualizing fewer than 10 mouse T cells with an enhanced firefly luciferase in immunocompetent mouse models of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

In vivo imaging enables high resolution preclinical trials on patients' leukemia cells growing in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Proteomics strategy for quantitative protein interaction profiling in cell extracts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

A guide to picking the most selective kinase inhibitor tool compounds for pharmacological validation of drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Determining target engagement in living systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Protein kinase networks that limit TLR signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

PGE(2) induces macrophage IL-10 production and a regulatory-like phenotype via a protein kinase A-SIK-CRTC3 pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

SIK inhibition in human myeloid cells modulates TLR and IL-1R signaling and induces an anti-inflammatory phenotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Cisplatin mimics ARF tumor suppressor regulation of RelA (p65) nuclear factor-kappaB transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Phosphoinositide-dependent kinase 1 provides negative feedback inhibition to Toll-like receptor-mediated NF-kappaB activation in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Dasatinib inhibits migration and invasion in diverse human sarcoma cell lines and induces apoptosis in bone sarcoma cells dependent on SRC kinase for survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

The importance of Src signaling in sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Serum regulation of Id1 expression by a BMP pathway and BMP responsive element

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Roles of bone morphogenetic protein signaling in osteosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Transcriptional repressor ERF is a Ras/mitogen-activated protein kinase target that regulates cellular proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

ERF nuclear shuttling, a continuous monitor of Erk activity that links it to cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Effect of mutations affecting Na+: H+ antiport activity on tumorigenic potential of hamster lung fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

FOXK2 Elicits Massive Transcription Repression and Suppresses the Hypoxic Response and Breast Cancer Carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Human BAHD1 promotes heterochromatic gene silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Analysis of p53 transactivation domain mutants reveals Acad11 as a metabolic target important for p53 pro-survival function

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Interactions with aromatic rings in chemical and biological recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

OTSSP167 Abrogates Mitotic Checkpoint through Inhibiting Multiple Mitotic Kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Preclinical evaluation of biomarkers associated with antitumor activity of MELK inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Phase IIB Trial of Oral Midostaurin (PKC412), the FMS-Like Tyrosine Kinase 3 Receptor (FLT3) and Multi-Targeted Kinase Inhibitor, in Patients With Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndrome With Either Wild-Type or Mutated FLT3

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Exome sequencing identifies recurring FLT3 N676K mutations in core-binding factor leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

MolProbity: all-atom structure validation for macromolecular crystallography

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

PHENIX: a comprehensive Python-based system for macromolecular structure solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Impact of FLT3-ITD location on sensitivity to TKI-therapy in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Prognostic Impact of Vitamin B6 Metabolism in Lung Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAN4368

Specificity and mechanism of action of some commonly used protein kinase inhibitors

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29191878

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Biochemistry. Resolving some old problems in protein crystallography

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29191878

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCIENCE.AAN4368

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29191878%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29191878%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

PubMed publication ID

29191878

1 reference