Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice (Q48275838)

10 February 2018

title

Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice (English)

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10 February 2018

5

Mattson MP

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10 February 2018

author name string

Begley JG

1

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10 February 2018

Duan W

2

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10 February 2018

Chan S

3

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10 February 2018

Duff K

4

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10 February 2018

language of work or name

English

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publication date

1 March 1999

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10 February 2018

Journal of Neurochemistry

published in

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10 February 2018

volume

72

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10 February 2018

issue

3

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10 February 2018

page(s)

1030-1039

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10 February 2018

Aging, energy, and oxidative stress in neurodegenerative diseases.

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Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

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Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

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An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos.

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Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

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β-Amyloid polypeptide increases calcium-uptake in PC12 cells: a possible mechanism for its cellular toxicity in Alzheimer's disease

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Presenilin-1 mutation alters NGF-induced neurite outgrowth, calcium homeostasis, and transcription factor (AP-1) activation in PC12 cells

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Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury

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Calbindin D28k blocks the proapoptotic actions of mutant presenilin 1: reduced oxidative stress and preserved mitochondrial function

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Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease

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Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation

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Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease

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Induction of a caspase-3-like activity by calcium in normal cytosolic extracts triggers nuclear apoptosis in a cell-free system

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Synaptic pathology of Alzheimer's disease

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Evidence for a six-transmembrane domain structure of presenilin 1.

21 January 2018

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Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

21 January 2018

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21 January 2018

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21 January 2018

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Characterization of human presenilin 1 using N-terminal specific monoclonal antibodies: Evidence that Alzheimer mutations affect proteolytic processing

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Human and rodent Alzheimer beta-amyloid peptides acquire distinct conformations in membrane-mimicking solvents

21 January 2018

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Amyloid beta-protein reduces acetylcholine synthesis in a cell line derived from cholinergic neurons of the basal forebrain.

21 January 2018

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Nerve growth factor-independent reduction in choline acetyltransferase activity in PC12 cells expressing mutant presenilin-1.

21 January 2018

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Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression

21 January 2018

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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

21 January 2018

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Skeletal and CNS defects in Presenilin-1-deficient mice

21 January 2018

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Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

21 January 2018

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Proteolytic fragments of the Alzheimer's disease associated presenilins-1 and -2 are phosphorylated in vivo by distinct cellular mechanisms

21 January 2018

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Formation of stable complexes between two Alzheimer's disease gene products: presenilin-2 and beta-amyloid precursor protein

21 January 2018

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Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

21 January 2018

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Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease

21 January 2018

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21 January 2018

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10.1046/J.1471-4159.1999.0721030.X

21 January 2018

Identifiers

DOI

1 reference

10 February 2018

1 reference

10 February 2018