Mendelian randomization: where are we now and where are we going? (Q48456096)

11 February 2018

editorial

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title

Mendelian randomization: where are we now and where are we going? (English)

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11 February 2018

author

Stephen Burgess

1

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11 February 2018

Nicholas J. Timpson

2

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11 February 2018

George Davey Smith

4

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11 February 2018

Shah Ebrahim

3

object named as

Shah Ebrahim

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11 February 2018

publication date

1 April 2015

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11 February 2018

International Journal of Epidemiology

published in

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11 February 2018

volume

44

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11 February 2018

page(s)

379-388

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11 February 2018

issue

2

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11 February 2018

‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?*

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The effect of elevated body mass index on ischemic heart disease risk: causal estimates from a Mendelian randomisation approach

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No evidence for a causal link between uric acid and type 2 diabetes: a Mendelian randomisation approach

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The causal role of smoking in anxiety and depression: a Mendelian randomization analysis of the HUNT study.

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Smoking is associated with, but does not cause, depressed mood in pregnancy--a mendelian randomization study

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The causal effect of malaria on stunting: a Mendelian randomization and matching approach

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The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis

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How does body fat influence bone mass in childhood? A Mendelian randomization approach

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Does greater adiposity increase blood pressure and hypertension risk?: Mendelian randomization using the FTO/MC4R genotype

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C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization

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Instrumental variable analysis with a nonlinear exposure-outcome relationship

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Testing for non-linear causal effects using a binary genotype in a Mendelian randomization study: application to alcohol and cardiovascular traits

21 January 2018

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Multivariable Mendelian randomization: the use of pleiotropic genetic variants to estimate causal effects

21 January 2018

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Using multivariable Mendelian randomization to disentangle the causal effects of lipid fractions

21 January 2018

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Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression

21 January 2018

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Association of low-density lipoprotein cholesterol-related genetic variants with aortic valve calcium and incident aortic stenosis

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Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index

21 January 2018

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Use of genetic markers and gene-diet interactions for interrogating population-level causal influences of diet on health

21 January 2018

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Mendelian Randomization for Strengthening Causal Inference in Observational Studies

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Epigenetic epidemiology of common complex disease: prospects for prediction, prevention, and treatment

21 January 2018

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Two-step epigenetic Mendelian randomization: a strategy for establishing the causal role of epigenetic processes in pathways to disease.

21 January 2018

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Postnatal growth and DNA methylation are associated with differential gene expression of the TACSTD2 gene and childhood fat mass

21 January 2018

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An epigenome-wide association study of total serum immunoglobulin E concentration.

21 January 2018

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Random allocation in observational data: how small but robust effects could facilitate hypothesis-free causal inference

21 January 2018

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Power and sample size calculations for Mendelian randomization studies using one genetic instrument

21 January 2018

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Power and instrument strength requirements for Mendelian randomization studies using multiple genetic variants

21 January 2018

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Efficient design for Mendelian randomization studies: subsample and 2-sample instrumental variable estimators

21 January 2018

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Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

21 January 2018

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Mendelian randomization analysis with multiple genetic variants using summarized data

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Metabolomics, pathway regulation, and pathway discovery

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Innovation: Metabolomics: the apogee of the omics trilogy

21 January 2018

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Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood

21 January 2018

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Sex hormone-binding globulin associations with circulating lipids and metabolites and the risk for type 2 diabetes: observational and causal effect estimates

21 January 2018

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Metabolic signatures of adiposity in young adults: Mendelian randomization analysis and effects of weight change

21 January 2018

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Interrogating causal pathways linking genetic variants, small molecule metabolites, and circulating lipids

21 January 2018

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Genome-wide association study identifies multiple loci influencing human serum metabolite levels

21 January 2018

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Metabolite profiles and the risk of developing diabetes

21 January 2018

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Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

21 January 2018

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Is epidemiology ready for epigenetics?

21 January 2018

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Mendelian randomization: genetic anchors for causal inference in epidemiological studies

21 January 2018

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Meeting-in-the-middle using metabolic profiling - a strategy for the identification of intermediate biomarkers in cohort studies

21 January 2018

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Human metabolic phenotype diversity and its association with diet and blood pressure.

21 January 2018

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DNA Methylation as a Long-term Biomarker of Exposure to Tobacco Smoke

21 January 2018

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DNA methylation signatures link prenatal famine exposure to growth and metabolism

21 January 2018

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Using Mendelian randomization to determine causative factors in cardiovascular disease

21 January 2018

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PLA2G7 genotype, lipoprotein-associated phospholipase A2 activity, and coronary heart disease risk in 10 494 cases and 15 624 controls of European Ancestry

21 January 2018

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Secretory phospholipase A(2)-IIA and cardiovascular disease: a mendelian randomization study

21 January 2018

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Genetically elevated bilirubin and risk of ischaemic heart disease: three Mendelian randomization studies and a meta-analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYV108

Association of plasma uric acid with ischaemic heart disease and blood pressure: mendelian randomisation analysis of two large cohorts

21 January 2018

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Mendelian randomisation applied to drug development in cardiovascular disease: a review.

21 January 2018

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Genetically elevated C-reactive protein and ischemic vascular disease

21 January 2018

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Anti-inflammatory therapies for cardiovascular disease

21 January 2018

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HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials

21 January 2018

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Effects of dalcetrapib in patients with a recent acute coronary syndrome

21 January 2018

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Torcetrapib and carotid intima-media thickness in mixed dyslipidaemia (RADIANCE 2 study): a randomised, double-blind trial

21 January 2018

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Separating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphisms

21 January 2018

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Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis

21 January 2018

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Causal effects of body mass index on cardiometabolic traits and events: a Mendelian randomization analysis

21 January 2018

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Genetically determined height and coronary artery disease

21 January 2018

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Credible Mendelian randomization studies: approaches for evaluating the instrumental variable assumptions

21 January 2018

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GWAS of 126,559 individuals identifies genetic variants associated with educational attainment

21 January 2018

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Genetic variation associated with differential educational attainment in adults has anticipated associations with school performance in children

21 January 2018

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Mining the human phenome using allelic scores that index biological intermediates

21 January 2018

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Mendelian randomization studies: a review of the approaches used and the quality of reporting

21 January 2018

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High tobacco consumption lowers body weight: a Mendelian randomization study of the Copenhagen General Population Study.

21 January 2018

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Coffee intake and risk of obesity, metabolic syndrome and type 2 diabetes: a Mendelian randomization study

21 January 2018

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https://api.crossref.org/works/10.1093%2FIJE%2FDYV108

Milk intake is not associated with ischaemic heart disease in observational or Mendelian randomization analyses in 98,529 Danish adults

21 January 2018

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https://api.crossref.org/works/10.1093%2FIJE%2FDYV108

Increased alcohol consumption as a cause of alcoholism, without similar evidence for depression: a Mendelian randomization study

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYV108

Adiposity as a cause of cardiovascular disease: a Mendelian randomization study

21 January 2018

1 reference

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Using genetics to test the causal relationship of total adiposity and periodontitis: Mendelian randomization analyses in the Gene-Lifestyle Interactions and Dental Endpoints (GLIDE) Consortium

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYV108

No evidence that genetically reduced 25-hydroxyvitamin D is associated with increased risk of ischaemic heart disease or myocardial infarction: a Mendelian randomization study

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYV108

Genetically predicted testosterone and electrocardiographic QT interval duration in Chinese: a Mendelian randomization analysis in the Guangzhou Biobank Cohort Study.

21 January 2018

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Limits to causal inference based on Mendelian randomization: a comparison with randomized controlled trials

21 January 2018

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Mendelian randomisation and causal inference in observational epidemiology

21 January 2018

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Methodological challenges in mendelian randomization

21 January 2018

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Use of allele scores as instrumental variables for Mendelian randomization

21 January 2018

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Assessing causality in the association between child adiposity and physical activity levels: a Mendelian randomization analysis

21 January 2018

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Statins and type 2 diabetes: genetic studies on target

21 January 2018

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21 January 2018

Identifiers

DOI

10.1093/IJE/DYV108

1 reference

11 February 2018

PubMed ID

26085674

1 reference

11 February 2018