Delivering drugs to the central nervous system: an overview. (Q48489684)

12 February 2018

title

Delivering drugs to the central nervous system: an overview. (English)

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12 February 2018

author name string

Patricia I Dickson

series ordinal

1

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12 February 2018

publication date

1 June 2012

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12 February 2018

Drug delivery and translational research

published in

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12 February 2018

volume

2

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12 February 2018

issue

3

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12 February 2018

page(s)

145-151

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12 February 2018

https://scigraph.springernature.com/pub.10.1007/s13346-012-0068-0

exact match

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cites work

Can the pharmaceutical industry reduce attrition rates?

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

Therapies for inborn errors of metabolism: what has the orphan drug act delivered?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

Convection-enhanced delivery of macromolecules in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

Progress report of a Phase I study of the intracerebral microinfusion of a recombinant chimeric protein composed of transforming growth factor (TGF)-alpha and a mutated form of the Pseudomonas exotoxin termed PE-38 (TP-38) for the treatment of malig

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

Treatment of late infantile neuronal ceroid lipofuscinosis by CNS administration of a serotype 2 adeno-associated virus expressing CLN2 cDNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

Versuche über Cocainisirung des Rückenmarkes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

Intranasal delivery of biologics to the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

The rostral migratory stream plays a key role in intranasal delivery of drugs into the CNS

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

Genetic engineering of a lysosomal enzyme fusion protein for targeted delivery across the human blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

Control of endothelial targeting and intracellular delivery of therapeutic enzymes by modulating the size and shape of ICAM-1-targeted carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

Molecular signatures of disease brain endothelia provide new sites for CNS-directed enzyme therapy

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1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

Intrathecal enzyme replacement therapy: successful treatment of brain disease via the cerebrospinal fluid

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1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

Injection of recombinant human sulfamidase into the CSF via the cerebellomedullary cistern in MPS IIIA mice.

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1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

Intrathecal tripeptidyl-peptidase 1 reduces lysosomal storage in a canine model of late infantile neuronal ceroid lipofuscinosis.

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1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

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21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

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1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

Glycosaminoglycan storage in neuroanatomical regions of mucopolysaccharidosis I dogs following intrathecal recombinant human iduronidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

CNS penetration of intrathecal-lumbar idursulfase in the monkey, dog and mouse: implications for neurological outcomes of lysosomal storage disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

Replacing the enzyme alpha-L-iduronidase at birth ameliorates symptoms in the brain and periphery of dogs with mucopolysaccharidosis type I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

Chemically modified beta-glucuronidase crosses blood-brain barrier and clears neuronal storage in murine mucopolysaccharidosis VII.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

Reversal of peripheral and central neural storage and ataxia after recombinant enzyme replacement therapy in alpha-mannosidosis mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

Overcoming the blood-brain barrier with high-dose enzyme replacement therapy in murine mucopolysaccharidosis VII.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

Research challenges in central nervous system manifestations of inborn errors of metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

Specific antibody titer alters the effectiveness of intrathecal enzyme replacement therapy in canine mucopolysaccharidosis I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

Cholesterol oxidation products are sensitive and specific blood-based biomarkers for Niemann-Pick C1 disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

Quantitative analysis of diffusion tensor imaging data in serial assessment of Krabbe disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

Adaptive design clinical trials and trial logistics models in CNS drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

Isofagomine in vivo effects in a neuronopathic Gaucher disease mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

Intracerebroventricular delivery of glucocerebrosidase reduces substrates and increases lifespan in a mouse model of neuronopathic Gaucher disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

The pharmacological chaperone 1-deoxygalactonojirimycin reduces tissue globotriaosylceramide levels in a mouse model of Fabry disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

Distribution of acid sphingomyelinase in rodent and non-human primate brain after intracerebroventricular infusion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

Comparative analysis of acid sphingomyelinase distribution in the CNS of rats and mice following intracerebroventricular delivery

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1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

Successful treatment of metachromatic leukodystrophy using bone marrow transplantation of HoxB4 overexpressing cells

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1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

Umbilical cord blood transplantation for juvenile metachromatic leukodystrophy

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1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

Reduced intensity conditioning haematopoietic stem cell transplantation with mesenchymal stromal cells infusion for the treatment of metachromatic leukodystrophy: a case report

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1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

Stabilization of juvenile metachromatic leukodystrophy after bone marrow transplantation: a 13-year follow-up.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

Intraventricular enzyme replacement improves disease phenotypes in a mouse model of late infantile neuronal ceroid lipofuscinosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

Large-volume intrathecal enzyme delivery increases survival of a mouse model of late infantile neuronal ceroid lipofuscinosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

Neuroprotection of host cells by human central nervous system stem cells in a mouse model of infantile neuronal ceroid lipofuscinosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

Survival advantage of neonatal CNS gene transfer for late infantile neuronal ceroid lipofuscinosis

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1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

Functional correction of CNS lesions in an MPS-IIIA mouse model by intracerebral AAV-mediated delivery of sulfamidase and SUMF1 genes

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1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

Significantly increased lifespan and improved behavioral performances by rAAV gene delivery in adult mucopolysaccharidosis IIIB mice

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1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

Intracranial injection of recombinant adeno-associated virus improves cognitive function in a murine model of mucopolysaccharidosis type VII.

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1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

Neural progenitor cell engraftment corrects lysosomal storage throughout the MPS VII mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

Decreased lysosomal storage in the adult MPS VII mouse brain in the vicinity of grafts of retroviral vector-corrected fibroblasts secreting high levels of beta-glucuronidase

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1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0068-0

Outcome in six children with mucopolysaccharidosis type IH, Hurler syndrome, after haematopoietic stem cell transplantation (HSCT).

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1 reference

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1 reference

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1 reference

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1 reference

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Identifiers

DOI

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12 February 2018

PubMed ID

25786863

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12 February 2018