Virulence-targeted Antibacterials: Concept, Promise, and Susceptibility to Resistance Mechanisms (Q48632952)

13 February 2018

editorial

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title

Virulence-targeted Antibacterials: Concept, Promise, and Susceptibility to Resistance Mechanisms (English)

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13 February 2018

author name string

Ségolène Ruer

1

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13 February 2018

Nikos Pinotsis

2

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13 February 2018

David Steadman

3

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13 February 2018

Gabriel Waksman

4

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13 February 2018

Han Remaut

5

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13 February 2018

publication date

14 January 2015

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13 February 2018

Chemical Biology and Drug Design

published in

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13 February 2018

volume

86

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13 February 2018

issue

4

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13 February 2018

page(s)

379-399

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13 February 2018

Targeting virulence: a new paradigm for antimicrobial therapy

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TonB-dependent outer membrane transport: going for Baroque?

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Recent studies on albomycin, a new antibiotic.

21 January 2018

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Crystal structure of the antibiotic albomycin in complex with the outer membrane transporter FhuA

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Active transport of an antibiotic rifamycin derivative by the outer-membrane protein FhuA

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The iron-siderophore transporter FhuA is the receptor for the antimicrobial peptide microcin J25: role of the microcin Val11-Pro16 beta-hairpin region in the recognition mechanism

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Siderophore-drug complexes: potential medicinal applications of the 'Trojan horse' strategy

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Comparison of different methods for thin section EM analysis of Mycobacterium smegmatis.

21 January 2018

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Mycobacterial outer membrane is a lipid bilayer and the inner membrane is unusually rich in diacyl phosphatidylinositol dimannosides

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Glucan is a component of the Mycobacterium tuberculosis surface that is expressed in vitro and in vivo

21 January 2018

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Direct visualization of the outer membrane of mycobacteria and corynebacteria in their native state

21 January 2018

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Disclosure of the mycobacterial outer membrane: cryo-electron tomography and vitreous sections reveal the lipid bilayer structure.

21 January 2018

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Mobility and temperature resistance of trehalose mycolates as key characteristics of the outer membrane of Mycobacterium tuberculosis

21 January 2018

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Genetic approaches to study of biofilms

21 January 2018

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Cystic fibrosis pathogenesis and the role of biofilms in persistent infection

21 January 2018

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Aminoglycoside antibiotics induce bacterial biofilm formation

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Mechanisms of resistance to beta-lactam antibiotics amongst Pseudomonas aeruginosa isolates collected in the UK in 1993.

21 January 2018

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Function of the Outer Membrane of Escherichia coli as a Permeability Barrier to Beta-Lactam Antibiotics

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics

21 January 2018

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Analysis of ribosomal proteins in streptomycin resistant and dependent mutants isolated from streptomycin independent Escherichia coli strains

21 January 2018

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Molecular basis of streptomycin resistance in Mycobacterium tuberculosis: alterations of the ribosomal protein S12 gene and point mutations within a functional 16S ribosomal RNA pseudoknot

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Erythromycin resistance by ribosome modification

21 January 2018

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Low Helicobacter pylori primary resistance to clarithromycin in gastric biopsy specimens from dyspeptic patients of a city in the interior of São Paulo, Brazil

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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A fluoroquinolone resistance protein from Mycobacterium tuberculosis that mimics DNA.

21 January 2018

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Stability, denaturation and refolding of Mycobacterium tuberculosis MfpA, a DNA mimicking protein that confers antibiotic resistance

21 January 2018

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DNA gyrase as a drug target

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Resistance to antibiotics mediated by target alterations

21 January 2018

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Updated functional classification of beta-lactamases

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Mechanisms of resistance to quinolones

21 January 2018

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The sociomicrobiology of antivirulence drug resistance: a proof of concept

21 January 2018

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Quorum Sensing in Bacteria

21 January 2018

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Can bacteria evolve resistance to quorum sensing disruption?

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Quorum quenching is an antivirulence strategy employed by endophytic bacteria

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Small molecules for interference with cell-cell-communication systems in Gram-negative bacteria.

21 January 2018

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Quorum sensing inhibitors: a patent review

21 January 2018

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Bacterial quorum sensing inhibitors: attractive alternatives for control of infectious pathogens showing multiple drug resistance

21 January 2018

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Quorum sensing inhibitors: a patent overview

21 January 2018

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Enzymatic synthesis of a quorum-sensing autoinducer through use of defined substrates.

21 January 2018

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Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing

21 January 2018

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Eukaryotic interference with homoserine lactone-mediated prokaryotic signalling

21 January 2018

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Inhibition of biofilm formation and swarming of Escherichia coli by (5Z)-4-bromo-5-(bromomethylene)-3-butyl-2(5H)-furanone

21 January 2018

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Medicinal Chemistry as a Conduit for the Modulation of Quorum Sensing

21 January 2018

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A Strategy for Antagonizing Quorum Sensing

21 January 2018

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Comparative analyses of N-acylated homoserine lactones reveal unique structural features that dictate their ability to activate or inhibit quorum sensing

21 January 2018

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Non-native N-aroyl L-homoserine lactones are potent modulators of the quorum sensing receptor RpaR in Rhodopseudomonas palustris

21 January 2018

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Molecular pharmacology of ABCG2 and its role in chemoresistance

21 January 2018

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Attenuation of quorum sensing in the pathogen Acinetobacter baumannii using non-native N-Acyl homoserine lactones

21 January 2018

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A quorum-sensing inhibitor blocks Pseudomonas aeruginosa virulence and biofilm formation

21 January 2018

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Design, synthesis, and a novel application of quorum-sensing agonists as potential drug-delivery vehicles.

21 January 2018

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Quorum quenching quandary: resistance to antivirulence compounds

21 January 2018

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Altering substrate chain length specificity of an acylhomoserine lactone synthase in bacterial communication

21 January 2018

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Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors

21 January 2018

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A quorum-sensing antagonist targets both membrane-bound and cytoplasmic receptors and controls bacterial pathogenicity

21 January 2018

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Cooperation and cheating in Pseudomonas aeruginosa: the roles of the las, rhl and pqs quorum-sensing systems

21 January 2018

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Competition studies confirm two major barriers that can preclude the spread of resistance to quorum-sensing inhibitors in bacteria

21 January 2018

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Suppression of type 1 pilus assembly in uropathogenic Escherichia coli by chemical inhibition of subunit polymerization

21 January 2018

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Mapping pilicide anti-virulence effect in Escherichia coli, a comprehensive structure-activity study

21 January 2018

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Chemical attenuation of pilus function and assembly in Gram-negative bacteria

21 January 2018

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Targeting virulence for antimicrobial chemotherapy

21 January 2018

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The molecular dissection of the chaperone-usher pathway

21 January 2018

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Intracellular bacterial biofilm-like pods in urinary tract infections.

21 January 2018

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P pili in uropathogenic E. coli are composite fibres with distinct fibrillar adhesive tips

21 January 2018

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https://api.crossref.org/works/10.1111%2FCBDD.12517

Outer-membrane PapC molecular usher discriminately recognizes periplasmic chaperone-pilus subunit complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Crystal structure of the FimD usher bound to its cognate FimC-FimH substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Structural basis of chaperone function and pilus biogenesis

21 January 2018

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https://api.crossref.org/works/10.1111%2FCBDD.12517

Chaperone priming of pilus subunits facilitates a topological transition that drives fiber formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Multivariate design, synthesis, and biological evaluation of peptide inhibitors of FimC/FimH protein-protein interactions in uropathogenic Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Design and Synthesis of C-2 Substituted Thiazolo and Dihydrothiazolo Ring-Fused 2-Pyridones: Pilicides with Increased Antivirulence Activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Lead optimization studies on FimH antagonists: discovery of potent and orally bioavailable ortho-substituted biphenyl mannosides

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Design, synthesis and biological evaluation of mannosyl triazoles as FimH antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Syntheses and biological evaluation of 2-amino-3-acyl-tetrahydrobenzothiophene derivatives; antibacterial agents with antivirulence activity

21 January 2018

1 reference

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Inhibition of P-fimbriated Escherichia coli adhesion by multivalent galabiose derivatives studied by a live-bacteria application of surface plasmon resonance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Structural Basis for Mechanical Force Regulation of the Adhesin FimH via Finger Trap-like β Sheet Twisting

21 January 2018

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https://api.crossref.org/works/10.1111%2FCBDD.12517

Reducing the fitness cost of antibiotic resistance by amplification of initiator tRNA genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Efflux-mediated antimicrobial resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

A periplasmic drug-binding site of the AcrB multidrug efflux pump: a crystallographic and site-directed mutagenesis study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Drug transport mechanism of the AcrB efflux pump

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Role of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: active efflux as a contributing factor to beta-lactam resistance

21 January 2018

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https://api.crossref.org/works/10.1111%2FCBDD.12517

Selective advantage of resistant strains at trace levels of antibiotics: a simple and ultrasensitive color test for detection of antibiotics and genotoxic agents

21 January 2018

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https://api.crossref.org/works/10.1111%2FCBDD.12517

Persistence of antibiotic resistance in bacterial populations.

21 January 2018

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https://api.crossref.org/works/10.1111%2FCBDD.12517

Crohn disease--associated adherent-invasive E. coli bacteria target mouse and human Peyer's patches via long polar fimbriae

21 January 2018

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FimH adhesin of type 1 fimbriae is a potent inducer of innate antimicrobial responses which requires TLR4 and type 1 interferon signalling

21 January 2018

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Regulated virulence controls the ability of a pathogen to compete with the gut microbiota.

21 January 2018

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Control of pathogens and pathobionts by the gut microbiota

21 January 2018

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https://api.crossref.org/works/10.1111%2FCBDD.12517

Effects of environment on compensatory mutations to ameliorate costs of antibiotic resistance

21 January 2018

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https://api.crossref.org/works/10.1111%2FCBDD.12517

Multiple drug-resistant Mycobacterium tuberculosis: evidence for changing fitness following passage through human hosts.

21 January 2018

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https://api.crossref.org/works/10.1111%2FCBDD.12517

An inhibitor of gram-negative bacterial virulence protein secretion

21 January 2018

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https://api.crossref.org/works/10.1111%2FCBDD.12517

Bacterial surface appendages as targets for novel antibacterial therapeutics.

21 January 2018

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https://api.crossref.org/works/10.1111%2FCBDD.12517

Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation

21 January 2018

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https://api.crossref.org/works/10.1111%2FCBDD.12517

Modulation of curli assembly and pellicle biofilm formation by chemical and protein chaperones

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Mechanisms of protein oligomerization: inhibitor of functional amyloids templates α-synuclein fibrillation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Novel strategy for biofilm inhibition by using small molecules targeting molecular chaperone DnaK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Inhibition of multidrug efflux as a strategy to prevent biofilm formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Loss of or inhibition of all multidrug resistance efflux pumps of Salmonella enterica serovar Typhimurium results in impaired ability to form a biofilm

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Single-molecule interrogation of a bacterial sugar transporter allows the discovery of an extracellular inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Biofilm dispersal: mechanisms, clinical implications, and potential therapeutic uses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Application of chimeric glucanase comprising mutanase and dextranase for prevention of dental biofilm formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Biologically inspired strategies for combating bacterial biofilms

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Antimicrobial and antibiofilm efficacy of triclosan and DispersinB combination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Indole as an intercellular signal in microbial communities

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

A flexible approach to 1,4-di-substituted 2-aminoimidazoles that inhibit and disperse biofilms and potentiate the effects of β-lactams against multi-drug resistant bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Indole/triazole conjugates are selective inhibitors and inducers of bacterial biofilms

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Reversal of Mycobacterium tuberculosis phenotypic drug resistance by 2-aminoimidazole-based small molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Disruption of heterotypic community development by Porphyromonas gingivalis with small molecule inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Membrane-permeabilizing activity of reverse-amide 2-aminoimidazole antibiofilm agents against Acinetobacter baumannii

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Inhibition of Acinetobacter baumannii biofilm formation on a methacrylate polymer containing a 2-aminoimidazole subunit.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Effects of N-pyrrole substitution on the anti-biofilm activities of oroidin derivatives against Acinetobacter baumannii

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Identification of aryl 2-aminoimidazoles as biofilm inhibitors in Gram-negative bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Inhibition of Acinetobacter baumannii, Staphylococcus aureus and Pseudomonas aeruginosa biofilm formation with a class of TAGE-triazole conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

N-substituted 2-aminoimidazole inhibitors of MRSA biofilm formation accessed through direct 1,3-bis(tert-butoxycarbonyl)guanidine cyclization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Small-molecule inhibition of bacterial two-component systems to combat antibiotic resistance and virulence

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Small molecule downregulation of PmrAB reverses lipid A modification and breaks colistin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Indole inhibits bacterial quorum sensing signal transmission by interfering with quorum sensing regulator folding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Identification of BfmR, a response regulator involved in biofilm development, as a target for a 2-Aminoimidazole-based antibiofilm agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Applying insights from biofilm biology to drug development - can a new approach be developed?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Novel bacterial ADP-ribosylating toxins: structure and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Imperfect vaccines and the evolution of pathogen virulence

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Microbial evolution: antitoxin vaccines and pathogen virulence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Pertussis resurgence: waning immunity and pathogen adaptation - two sides of the same coin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

The Crystal Structure of Shiga Toxin Type 2 with Bound Disaccharide Guides the Design of a Heterobifunctional Toxin Inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Native cell wall organization shown by cryo-electron microscopy confirms the existence of a periplasmic space in Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Cyclic diguanylate is a ubiquitous signaling molecule in bacteria: insights into biochemistry of the GGDEF protein domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Monitoring of diguanylate cyclase activity and of cyclic-di-GMP biosynthesis by whole-cell assays suitable for high-throughput screening of biofilm inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

AHL-driven quorum-sensing circuits: their frequency and function among the Proteobacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Degradation of fluoroquinolone antibiotics and identification of metabolites/transformation products by liquid chromatography–tandem mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12517

Albomycin: Studies on fermentation, isolation and quantitative determination

21 January 2018

1 reference

11 May 2024

https://opencitations.net/index/api/v1/citations/10.1007/BF00249977

Identifiers

DOI

10.1111/CBDD.12517

1 reference

13 February 2018

1 reference

13 February 2018