The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer (Q49966667)

2 July 2018

title

The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer (English)

1 reference

2 July 2018

1 reference

Ambrosius P. Snijders

6

1 reference

2 July 2018

Richard Mitter

object named as

Richard Mitter

4

0 references

author name string

Omar M Khan

1

1 reference

2 July 2018

Joana Carvalho

2

1 reference

2 July 2018

Bradley Spencer-Dene

3

1 reference

2 July 2018

David Frith

5

1 reference

2 July 2018

Stephen A Wood

7

1 reference

2 July 2018

Axel Behrens

8

1 reference

2 July 2018

language of work or name

English

0 references

publication date

26 February 2018

1 reference

2 July 2018

Journal of Clinical Investigation

published in

1 reference

2 July 2018

volume

128

1 reference

2 July 2018

issue

4

1 reference

2 July 2018

page(s)

1326-1337

1 reference

2 July 2018

Tumor-suppressor genes that escape from X-inactivation contribute to cancer sex bias

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5873885

Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5873885

Genomic Alterations Observed in Colitis-Associated Cancers Are Distinct From Those Found in Sporadic Colorectal Cancers and Vary by Type of Inflammatory Bowel Disease

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5873885

Ubiquitin-specific protease 22 is a deubiquitinase of CCNB1.

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5873885

Usp28 counteracts Fbw7 in intestinal homeostasis and cancer

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5873885

The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5873885

Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5873885

Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5873885

Comprehensive molecular characterization of human colon and rectal cancer

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5873885

The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5873885

Negative regulation of the stability and tumor suppressor function of Fbw7 by the Pin1 prolyl isomerase

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5873885

The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5873885

GSK-3β regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1α

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5873885

Global quantification of mammalian gene expression control

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5873885

FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5873885

c-Jun N-terminal phosphorylation antagonises recruitment of the Mbd3/NuRD repressor complex

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5873885

Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5873885

Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5873885

Breaking the chains: structure and function of the deubiquitinases

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5873885

JNK signalling modulates intestinal homeostasis and tumourigenesis in mice

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5873885

The ubiquitin-proteasome system in colorectal cancer

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5873885

Current view: intestinal stem cells and signaling

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5873885

Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2.

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5873885

FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5873885

Fbw7 and Usp28 regulate myc protein stability in response to DNA damage

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5873885

Myc deletion rescues Apc deficiency in the small intestine

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5873885

WNT signaling in the normal intestine and colorectal cancer

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5873885

Wnt/beta-catenin signaling in development and disease

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5873885

The ubiquitin ligase itch is auto-ubiquitylated in vivo and in vitro but is protected from degradation by interacting with the deubiquitylating enzyme FAM/USP9X

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5873885

The consensus coding sequences of human breast and colorectal cancers

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5873885

The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5873885

Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5873885

Lessons from hereditary colorectal cancer

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5873885

Ulcerative colitis and colorectal cancer. A population-based study

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5873885

Increased risk of large-bowel cancer in Crohn's disease with colonic involvement

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5873885

Dual regulation of Fbw7 function and oncogenic transformation by Usp28.

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5873885

The F-box protein Fbw7 is required for cerebellar development

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5873885

Fbxw7β resides in the endoplasmic reticulum membrane and protects cells from oxidative stress.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5873885

F-box and WD repeat domain-containing 7 regulates intestinal cell lineage commitment and is a haploinsufficient tumor suppressor.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5873885

Beta-Catenin mutations in a mouse model of inflammation-related colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sodium sulfate

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5873885

Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5873885

Tissue-specific and inducible Cre-mediated recombination in the gut epithelium

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5873885

Loss of Apc+ in intestinal adenomas from Min mice

14 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29346117

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Notch signals control the fate of immature progenitor cells in the intestine

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29346117

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1172/JCI97325

1 reference

2 July 2018

release_gpy5qhh555dgxa267jb2xtnbpu

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/gpy5qhh555dgxa267jb2xtnbpu

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMC publication ID

5873885

1 reference

2 July 2018

PubMed publication ID

29346117

1 reference

2 July 2018