R248Q mutation--Beyond p53-DNA binding. (Q50797771)

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26 February 2020

title

R248Q mutation--Beyond p53-DNA binding (English)

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26 February 2020

4

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26 February 2020

author name string

Jeremy W K Ng

1

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26 February 2020

Dilraj Lama

2

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26 February 2020

Suryani Lukman

3

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26 February 2020

Chandra S Verma

5

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26 February 2020

Adelene Y L Sim

6

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26 February 2020

language of work or name

English

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publication date

27 October 2015

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26 February 2020

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26 February 2020

volume

83

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26 February 2020

page(s)

2240-2250

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26 February 2020

issue

12

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Cancer. p53, guardian of the genome

26 February 2020

cites work

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24940

21 January 2018

Surfing the p53 network

1 reference

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Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence

21 January 2018

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Mutations in the p53 gene occur in diverse human tumour types

21 January 2018

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p53 mutations in human cancers

21 January 2018

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Molecular architecture of tumor suppressor p53.

21 January 2018

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The IARC TP53 database: new online mutation analysis and recommendations to users

21 January 2018

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Thermodynamic stability of wild-type and mutant p53 core domain

21 January 2018

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Structural basis of DNA recognition by p53 tetramers.

21 January 2018

1 reference

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Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy

21 January 2018

1 reference

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Effects of temperature on the p53-DNA binding interactions and their dynamical behavior: comparing the wild type to the R248Q mutant.

21 January 2018

1 reference

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Structure, function, and aggregation of the zinc-free form of the p53 DNA binding domain

21 January 2018

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Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database

21 January 2018

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Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

21 January 2018

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Hot-spot mutants of p53 core domain evince characteristic local structural changes.

21 January 2018

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Single-Molecule characterization of oligomerization kinetics and equilibria of the tumor suppressor p53.

21 January 2018

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Structure of the p53 core domain dimer bound to DNA.

21 January 2018

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Structure of the human p53 core domain in the absence of DNA

21 January 2018

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Folding of tetrameric p53: oligomerization and tumorigenic mutations induce misfolding and loss of function

21 January 2018

1 reference

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Interaction of the p53 DNA-Binding Domain with Its N-Terminal Extension Modulates the Stability of the p53 Tetramer

21 January 2018

1 reference

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Comparison of multiple Amber force fields and development of improved protein backbone parameters

21 January 2018

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Comparison of simple potential functions for simulating liquid water

21 January 2018

1 reference

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Stability of the core domain of p53: insights from computer simulations

21 January 2018

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Particle mesh Ewald: An N⋅log(N) method for Ewald sums in large systems

21 January 2018

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Bio3d: an R package for the comparative analysis of protein structures.

21 January 2018

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VMD: visual molecular dynamics

21 January 2018

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GROMACS: fast, flexible, and free

21 January 2018

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Quantifying Correlations Between Allosteric Sites in Thermodynamic Ensembles

21 January 2018

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Mapping the structural and dynamical features of multiple p53 DNA binding domains: insights into loop 1 intrinsic dynamics

21 January 2018

1 reference

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Folding and binding cascades: dynamic landscapes and population shifts

21 January 2018

1 reference

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Regulation of mutant p53 temperature-sensitive DNA binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24940

Structural basis for understanding oncogenic p53 mutations and designing rescue drugs

21 January 2018

1 reference

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Comparing Conformational Ensembles Using the Kullback-Leibler Divergence Expansion

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24940

Folding and misfolding mechanisms of the p53 DNA binding domain at physiological temperature

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24940

In the quest for stable rescuing mutants of p53: computational mutagenesis of flexible loop L1.

21 January 2018

1 reference

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Computational identification of a transiently open L1/S3 pocket for reactivation of mutant p53

21 January 2018

1 reference

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Using Ligand-Mapping Simulations to Design a Ligand Selectively Targeting a Cryptic Surface Pocket of Polo-Like Kinase 1

21 January 2018

1 reference

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Small molecule restoration of wildtype structure and function of mutant p53 using a novel zinc-metallochaperone based mechanism

21 January 2018

1 reference

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Mutant p53 aggregates into prion-like amyloid oligomers and fibrils: implications for cancer.

21 January 2018

1 reference

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Towards inferring time dimensionality in protein-protein interaction networks by integrating structures: the p53 example

21 January 2018

1 reference

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Gain of function of mutant p53 by coaggregation with multiple tumor suppressors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24940

Mutants of the tumour suppressor p53 L1 loop as second-site suppressors for restoring DNA binding to oncogenic p53 mutations: structural and biochemical insights

21 January 2018

1 reference

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Effect of Zn2+on DNA Recognition and Stability of the p53 DNA-Binding Domain†

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1002/PROT.24940

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26442703%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

1 reference