Computational identification of a transiently open L1/S3 pocket for reactivation of mutant p53 (Q24628577)

23 June 2017

Computational identification of a transiently open L1/S3 pocket for reactivation of mutant p53 (English)

1 reference

Christopher Douglas Wassman

23 June 2017

1

object named as

Christopher D Wassman

1 reference

23 June 2017

3

Özlem Demir

1 reference

23 June 2017

10

G Wesley Hatfield

1 reference

23 June 2017

12

0 references

Richard Harold Lathrop

13

object named as

Richard H Lathrop

1 reference

23 June 2017

Roberta Baronio

2

1 reference

23 June 2017

Brad D Wallentine

4

1 reference

23 June 2017

Chiung-Kuang Chen

5

1 reference

23 June 2017

Linda V Hall

6

1 reference

23 June 2017

Faezeh Salehi

7

1 reference

23 June 2017

Da-Wei Lin

8

1 reference

23 June 2017

Benjamin P Chung

9

1 reference

23 June 2017

A Richard Chamberlin

11

1 reference

23 June 2017

Peter Kaiser

14

1 reference

23 June 2017

Rommie E Amaro

15

1 reference

23 June 2017

Hartmut Luecke

12

1 reference

23 June 2017

language of work or name

English

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publication date

1 January 2013

1 reference

23 June 2017

Nature Communications

1 reference

23 June 2017

4

1 reference

23 June 2017

1407

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Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported

23 June 2017

start time

29 January 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity

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A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants

7 April 2017

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Thermodynamic stability of wild-type and mutant p53 core domain

7 April 2017

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Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53

7 April 2017

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Crystal structure of a multidomain human p53 tetramer bound to the natural CDKN1A (p21) p53-response element

7 April 2017

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Interaction of the p53 DNA-Binding Domain with Its N-Terminal Extension Modulates the Stability of the p53 Tetramer

7 April 2017

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Crystal structure of a p53 core tetramer bound to DNA

7 April 2017

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Targeted rescue of a destabilized mutant of p53 by an in silico screened drug

7 April 2017

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Structure of the human p53 core domain in the absence of DNA

7 April 2017

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Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

7 April 2017

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7 April 2017

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AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

7 April 2017

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Comparison of multiple Amber force fields and development of improved protein backbone parameters

7 April 2017

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Scalable molecular dynamics with NAMD

7 April 2017

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7 April 2017

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Homology modeling, model and software evaluation: three related resources

7 April 2017

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Development and testing of a general amber force field

7 April 2017

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Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

7 April 2017

1 reference

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Restoration of p53 function leads to tumour regression in vivo

7 April 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562459

Automatic atom type and bond type perception in molecular mechanical calculations

7 April 2017

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Allele-specific p53 mutant reactivation

7 April 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562459

Using targeted transgenic reporter mice to study promoter-specific p53 transcriptional activity.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562459

Ensemble-based computational approach discriminates functional activity of p53 cancer and rescue mutants

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562459

All-codon scanning identifies p53 cancer rescue mutations

27 September 2017

1 reference

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The tumor suppressor p53: from structures to drug discovery

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562459

Pharmacological reactivation of mutant p53: from protein structure to the cancer patient

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562459

Predicting positive p53 cancer rescue regions using Most Informative Positive (MIP) active learning

27 September 2017

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Fpocket: an open source platform for ligand pocket detection.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562459

PRIMA-1 reactivates mutant p53 by covalent binding to the core domain

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562459

Fragment-based identification of druggable 'hot spots' of proteins using Fourier domain correlation techniques

27 September 2017

1 reference

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Ensemble-based virtual screening reveals potential novel antiviral compounds for avian influenza neuraminidase.

27 September 2017

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An improved relaxed complex scheme for receptor flexibility in computer-aided drug design

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562459

Human p53 is inhibited by glutathionylation of cysteines present in the proximal DNA-binding domain during oxidative stress.

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562459

Restoration of wild-type p53 function in human tumors: strategies for efficient cancer therapy.

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562459

Reactivation of mutant p53: molecular mechanisms and therapeutic potential

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562459

Modeling the therapeutic efficacy of p53 restoration in tumors

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562459

Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562459

Solution structure of p53 core domain: structural basis for its instability

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562459

Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562459

Identification and structure-activity relationship studies of 3-methylene-2-norbornanone as potent anti-proliferative agents presumably working through p53 mediated apoptosis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562459

A global suppressor motif for p53 cancer mutants

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562459

Assessing TP53 status in human tumours to evaluate clinical outcome

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562459

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562459

Restoration of wild-type conformation and activity of a temperature-sensitive mutant of p53 (p53(V272M)) by the cytoprotective aminothiol WR1065 in the esophageal cancer cell line TE-1.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562459

Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562459

Genetic selection of intragenic suppressor mutations that reverse the effect of common p53 cancer mutations

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562459

Stabilization of mutant p53 via alkylation of cysteines and effects on DNA binding

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562459

Mutant p53 targeting by the low molecular weight compound STIMA-1

27 September 2017

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Dynamics, hydration, and motional averaging of a loop-gated artificial protein cavity: the W191G mutant of cytochrome c peroxidase in water as revealed by molecular dynamics simulations

30 May 2018

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Choosing where to look next in a mutation sequence space: Active Learning of informative p53 cancer rescue mutants

30 May 2018

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Functional census of mutation sequence spaces: the example of p53 cancer rescue mutants.

30 May 2018

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The IARC TP53 database: new online mutation analysis and recommendations to users

30 May 2018

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21 January 2018

Gone but not forgotten

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Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known anticancer drugs: a statistical analysis of information in the National Cancer Institute database.

21 January 2018

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Comparison of simple potential functions for simulating liquid water

21 January 2018

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Structure-based rescue of common tumor-derived p53 mutants

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23360998

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Novel Zinc Protein Molecular Dynamics Simulations: Steps Toward Antiangiogenesis for Cancer Treatment

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS2361

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NCOMMS2361

1 reference

Dimensions Publication ID

23 June 2017

0 references

1009779547

0 references

Google Scholar paper ID

12987355720576281723

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OpenCitations bibliographic resource ID

877400

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference