An off-target effect of BX795 blocks herpes simplex virus type 1 infection of the eye. (Q53708426)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29444978%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

title

An off-target effect of BX795 blocks herpes simplex virus type 1 infection of the eye (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29444978%20AND%20SRC:MED&resulttype=core&format=json

Herpes simplex virus type 1

17 March 2020

main subject

1 reference

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29444978%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Dinesh Jaishankar

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29444978%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Tejabhiram Yadavalli

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29444978%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Neel Thakkar

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29444978%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Joshua Ames

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29444978%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

author name string

Abraam M Yakoub

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29444978%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Alex Agelidis

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29444978%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Satvik Hadigal

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29444978%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

language of work or name

English

0 references

publication date

1 February 2018

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29444978%20AND%20SRC:MED&resulttype=core&format=json

Science Translational Medicine

17 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29444978%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

volume

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29444978%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

issue

428

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29444978%20AND%20SRC:MED&resulttype=core&format=json

Regulation of herpesvirus macromolecular synthesis: sequential transition of polypeptide synthesis requires functional viral polypeptides

17 March 2020

cites work

1 reference

12 December 2020

Trifluridine-associated conjunctival cicatrization

1 reference

12 December 2020

Acute renal failure and coma secondary to acyclovir therapy

1 reference

12 December 2020

Characterization of the herpes simplex virion-associated factor responsible for the induction of alpha genes.

1 reference

12 December 2020

Corneal epithelial dysplasia after trifluridine use

1 reference

12 December 2020

Antiviral medications and corneal wound healing

1 reference

12 December 2020

Preclinical toxicology studies with acyclovir: genetic toxicity tests

1 reference

12 December 2020

Severe reversible ocular anterior segment ischaemia following topical trifluorothymidine (F3T) treatment for herpes simplex keratouveitis

1 reference

12 December 2020

Incorporation of the green fluorescent protein into the herpes simplex virus type 1 capsid

1 reference

12 December 2020

Rsk1 mediates a MEK-MAP kinase cell survival signal

1 reference

12 December 2020

Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A

1 reference

12 December 2020

Herpes simplex virus infections

1 reference

12 December 2020

MAPK signal pathways in the regulation of cell proliferation in mammalian cells

1 reference

12 December 2020

Management of acyclovir-resistant herpes simplex virus

1 reference

12 December 2020

Phosphorylation of eIF4E by Mnk-1 enhances HSV-1 translation and replication in quiescent cells

1 reference

12 December 2020

Regulation of cap-dependent translation by eIF4E inhibitory proteins

1 reference

12 December 2020

Herpes simplex virus thymidine kinase mutations associated with resistance to acyclovir: a site-directed mutagenesis study

1 reference

12 December 2020

The Akt of translational control

1 reference

12 December 2020

Protein kinase B/Akt is present in activated form throughout the entire replicative cycle of deltaU(S)3 mutant virus but only at early times after infection with wild-type herpes simplex virus 1

1 reference

12 December 2020

The mTOR pathway in the control of protein synthesis

1 reference

12 December 2020

Effects of protein phosphorylation on ubiquitination and stability of the translational inhibitor protein 4E-BP1.

1 reference

12 December 2020

Control of TANK-binding kinase 1-mediated signaling by the gamma(1)34.5 protein of herpes simplex virus 1

1 reference

12 December 2020

Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation

1 reference

12 December 2020

Molecular mechanisms of mTOR-mediated translational control

1 reference

12 December 2020

p38 mitogen-activated protein kinase promotes cell survival in response to DNA damage but is not required for the G(2) DNA damage checkpoint in human cancer cells

1 reference

12 December 2020

Corneal sensation and subbasal nerve alterations in patients with herpes simplex keratitis: an in vivo confocal microscopy study.

1 reference

12 December 2020

Phosphoinositide 3 kinase signalling may affect multiple steps during herpes simplex virus type-1 entry

1 reference

12 December 2020

Acyclovir nephrotoxicity: a case report highlighting the importance of prevention, detection, and treatment of acyclovir-induced nephropathy

1 reference

12 December 2020

Constitutive mTORC1 activation by a herpesvirus Akt surrogate stimulates mRNA translation and viral replication

1 reference

12 December 2020

Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases

1 reference

12 December 2020

IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.

1 reference

12 December 2020

A herpesvirus kinase that masquerades as Akt: you don't have to look like Akt, to act like it.

1 reference

12 December 2020

Viral subversion of the host protein synthesis machinery

1 reference

12 December 2020

p38α mediates cell survival in response to oxidative stress via induction of antioxidant genes: effect on the p70S6K pathway

1 reference

12 December 2020

Inhibition of TANK binding kinase 1 by herpes simplex virus 1 facilitates productive infection

1 reference

12 December 2020

TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2.

1 reference

12 December 2020

HijAkt: The PI3K/Akt pathway in virus replication and pathogenesis

1 reference

12 December 2020

Herpes simplex epithelial and stromal keratitis: an epidemiologic update

1 reference

12 December 2020

Recent insights into the complexity of Tank-binding kinase 1 signaling networks: the emerging role of cellular localization in the activation and substrate specificity of TBK1.

1 reference

12 December 2020

Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases.

1 reference

12 December 2020

Make yourself at home: viral hijacking of the PI3K/Akt signaling pathway

1 reference

12 December 2020

Persistent infection by HSV-1 is associated with changes in functional architecture of iPSC-derived neurons and brain activation patterns underlying working memory performance

1 reference

12 December 2020

Transcription of the herpes simplex virus 1 genome during productive and quiescent infection of neuronal and nonneuronal cells

1 reference

12 December 2020

HSV-1 ICP0: An E3 Ubiquitin Ligase That Counteracts Host Intrinsic and Innate Immunity

1 reference

12 December 2020

Characterization of a proteolytically stable D-peptide that suppresses herpes simplex virus 1 infection: implications for the development of entry-based antiviral therapy

1 reference

12 December 2020

Glycogen synthase kinase-3 (GSK3) inhibition induces prosurvival autophagic signals in human pancreatic cancer cells

1 reference

12 December 2020

Ocular drug delivery systems: An overview

1 reference

12 December 2020

The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside

1 reference

12 December 2020

Autophagy stimulation abrogates herpes simplex virus-1 infection

1 reference

12 December 2020

Heparanase is a host enzyme required for herpes simplex virus-1 release from cells

1 reference

12 December 2020

TBK1 controls autophagosomal engulfment of polyubiquitinated mitochondria through p62/SQSTM1 phosphorylation

1 reference

12 December 2020

Basal Autophagy Is Required for Herpes simplex Virus-2 Infection

1 reference

12 December 2020

Extended Release of an Anti-Heparan Sulfate Peptide From a Contact Lens Suppresses Corneal Herpes Simplex Virus-1 Infection.

1 reference

12 December 2020

New strategies against drug resistance to herpes simplex virus

1 reference

12 December 2020

Corneal Sensitivity to Hyperosmolar Eye Drops: A Novel Behavioral Assay to Assess Diabetic Peripheral Neuropathy

1 reference

12 December 2020

Human TBK1: A Gatekeeper of Neuroinflammation

1 reference

12 December 2020

Herpes simplex virus keratitis: an update of the pathogenesis and current treatment with oral and topical antiviral agents.

1 reference

12 December 2020

IL-6 Contributes to Corneal Nerve Degeneration after Herpes Simplex Virus Type I Infection

1 reference

12 December 2020

RSK1 protects P-glycoprotein/ABCB1 against ubiquitin-proteasomal degradation by downregulating the ubiquitin-conjugating enzyme E2 R1

1 reference

12 December 2020

Rapamycin Prolongs the Survival of Corneal Epithelial Cells in Culture

1 reference

12 December 2020

BX-795 inhibits HSV-1 and HSV-2 replication by blocking the JNK/p38 pathways without interfering with PDK1 activity in host cells

1 reference

12 December 2020

Cultured corneas show dendritic spread and restrict herpes simplex virus infection that is not observed with cultured corneal cells.

1 reference

12 December 2020

Zinc oxide tetrapods inhibit herpes simplex virus infection of cultured corneas

1 reference

12 December 2020

Genital Herpes: Insights into Sexually Transmitted Infectious Disease

1 reference

12 December 2020

Acute kidney injury due to acyclovir.

1 reference

12 December 2020

Viral Activation of Heparanase Drives Pathogenesis of Herpes Simplex Virus-1.

1 reference

12 December 2020

10.1126/SCITRANSLMED.AAN5861

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29444978%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

1 reference