The glucagon-like peptide-1 receptor agonist exenatide restores impaired pro-islet amyloid polypeptide processing in cultured human islets: implications in type 2 diabetes and islet transplantation. (Q54463919)

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English	The glucagon-like peptide-1 receptor agonist exenatide restores impaired pro-islet amyloid polypeptide processing in cultured human islets: implications in type 2 diabetes and islet transplantation.	scientific article

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scholarly article

1 reference

Europe PubMed Central

30 May 2018

http://europepmc.org/abstract/MED/23262664

The glucagon-like peptide-1 receptor agonist exenatide restores impaired pro-islet amyloid polypeptide processing in cultured human islets: implications in type 2 diabetes and islet transplantation. (English)

1 reference

Europe PubMed Central

30 May 2018

http://europepmc.org/abstract/MED/23262664

type 2 diabetes

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author name string

Y J Park

1

1 reference

Europe PubMed Central

30 May 2018

http://europepmc.org/abstract/MED/23262664

Z Ao

2

1 reference

Europe PubMed Central

30 May 2018

http://europepmc.org/abstract/MED/23262664

T J Kieffer

3

1 reference

Europe PubMed Central

30 May 2018

http://europepmc.org/abstract/MED/23262664

H Chen

4

1 reference

Europe PubMed Central

30 May 2018

http://europepmc.org/abstract/MED/23262664

N Safikhan

5

1 reference

Europe PubMed Central

30 May 2018

http://europepmc.org/abstract/MED/23262664

D M Thompson

6

1 reference

Europe PubMed Central

30 May 2018

http://europepmc.org/abstract/MED/23262664

M Meloche

7

1 reference

Europe PubMed Central

30 May 2018

http://europepmc.org/abstract/MED/23262664

G L Warnock

8

1 reference

Europe PubMed Central

30 May 2018

http://europepmc.org/abstract/MED/23262664

L Marzban

9

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Europe PubMed Central

30 May 2018

http://europepmc.org/abstract/MED/23262664

publication date

23 December 2012

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Europe PubMed Central

30 May 2018

http://europepmc.org/abstract/MED/23262664

1 reference

Europe PubMed Central

30 May 2018

http://europepmc.org/abstract/MED/23262664

56

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Europe PubMed Central

30 May 2018

http://europepmc.org/abstract/MED/23262664

3

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Europe PubMed Central

30 May 2018

http://europepmc.org/abstract/MED/23262664

508-519

1 reference

Europe PubMed Central

30 May 2018

http://europepmc.org/abstract/MED/23262664

https://scigraph.springernature.com/pub.10.1007/s00125-012-2802-z

0 references

Mechanisms of beta-cell death in type 2 diabetes.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2802-Z

21 January 2018

Islet beta cell failure in type 2 diabetes

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2802-Z

21 January 2018

Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2802-Z

21 January 2018

Islet amyloid polypeptide, islet amyloid, and diabetes mellitus

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2802-Z

21 January 2018

β-cell loss and β-cell apoptosis in human type 2 diabetes are related to islet amyloid deposition

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2802-Z

21 January 2018

Small interfering RNA-mediated suppression of proislet amyloid polypeptide expression inhibits islet amyloid formation and enhances survival of human islets in culture

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2802-Z

21 January 2018

Differences between amyloid toxicity in alpha and beta cells in human and mouse islets and the role of caspase-3.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2802-Z

21 January 2018

Islet amyloid deposition limits the viability of human islet grafts but not porcine islet grafts

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2802-Z

21 January 2018

Further evidence for amyloid deposition in clinical pancreatic islet grafts

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2802-Z

21 January 2018

Amyloid formation results in recurrence of hyperglycaemia following transplantation of human IAPP transgenic mouse islets

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2802-Z

21 January 2018

IL-1 blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2802-Z

21 January 2018

Membrane damage by human islet amyloid polypeptide through fibril growth at the membrane

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2802-Z

21 January 2018

Islet amyloid polypeptide demonstrates a persistent capacity to disrupt membrane integrity

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2802-Z

21 January 2018

Fas-associated death receptor signaling evoked by human amylin in islet beta-cells

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2802-Z

21 January 2018

Identification of a heparin binding domain in the N-terminal cleavage site of pro-islet amyloid polypeptide. Implications for islet amyloid formation

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2802-Z

21 January 2018

Calcium elevation in mouse pancreatic beta cells evoked by extracellular human islet amyloid polypeptide involves activation of the mechanosensitive ion channel TRPV4.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2802-Z

21 January 2018

High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2802-Z

21 January 2018

β-cell dysfunctional ERAD/ubiquitin/proteasome system in type 2 diabetes mediated by islet amyloid polypeptide-induced UCH-L1 deficiency

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2802-Z

21 January 2018

Oxidative stress is induced by islet amyloid formation and time-dependently mediates amyloid-induced beta cell apoptosis

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2802-Z

21 January 2018

cJUN N-terminal kinase (JNK) activation mediates islet amyloid-induced beta cell apoptosis in cultured human islet amyloid polypeptide transgenic mouse islets.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2802-Z

21 January 2018

Human-IAPP disrupts the autophagy/lysosomal pathway in pancreatic β-cells: protective role of p62-positive cytoplasmic inclusions

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2802-Z

21 January 2018

Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2802-Z

21 January 2018

Processing of pro-islet amyloid polypeptide in the constitutive and regulated secretory pathways of beta cells

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2802-Z

21 January 2018

Exendin-4 increases islet amyloid deposition but offsets the resultant beta cell toxicity in human islet amyloid polypeptide transgenic mouse islets.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2802-Z

21 January 2018

Aberrant processing of human proislet amyloid polypeptide results in increased amyloid formation

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2802-Z

21 January 2018

Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2802-Z

21 January 2018

The prohormone convertase enzyme 2 (PC2) is essential for processing pro-islet amyloid polypeptide at the NH2-terminal cleavage site

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2802-Z

21 January 2018

Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2802-Z

21 January 2018

Glucagon-like peptide-1 protects beta cells from cytokine-induced apoptosis and necrosis: role of protein kinase B.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2802-Z

21 January 2018

Glucagon-like peptide-1 agonists protect pancreatic beta-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2802-Z

21 January 2018

Different effects of FK506, rapamycin, and mycophenolate mofetil on glucose-stimulated insulin release and apoptosis in human islets.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2802-Z

21 January 2018

Exendin-4 protects pancreatic beta cells from human islet amyloid polypeptide-induced cell damage: potential involvement of AKT and mitochondria biogenesis

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2802-Z

21 January 2018

DsAAV8-mediated expression of glucagon-like peptide-1 in pancreatic beta-cells ameliorates streptozotocin-induced diabetes

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2802-Z

21 January 2018

Treatment of type 2 diabetes with glucagon-like peptide-1 receptor agonists.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2802-Z

21 January 2018

Long-term metabolic and hormonal effects of exenatide on islet transplant recipients with allograft dysfunction

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2802-Z

21 January 2018

Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2802-Z

21 January 2018

Transgenic overproduction of islet amyloid polypeptide (amylin) is not sufficient for islet amyloid formation

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2802-Z

21 January 2018

The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2802-Z

21 January 2018

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers

1 reference

https://api.crossref.org/works/10.1007%2FS00125-012-2802-Z

21 January 2018

Widespread amyloid deposition in transplanted human pancreatic islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/23262664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deletion of Fas protects islet beta cells from cytotoxic effects of human islet amyloid polypeptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/23262664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence of cosecretion of islet amyloid polypeptide and insulin by beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23262664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of exenatide on beta cell function after islet transplantation in type 1 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23262664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23262664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prolonged exposure of pancreatic beta cells to raised glucose concentrations results in increased cellular content of islet amyloid polypeptide precursors

1 reference

https://pubmed.ncbi.nlm.nih.gov/23262664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/23262664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Incretin-based therapies in the management of type 2 diabetes: rationale and reality in a managed care setting

1 reference

https://pubmed.ncbi.nlm.nih.gov/23262664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differences in amyloid deposition in islets of transgenic mice expressing human islet amyloid polypeptide versus human islets implanted into nude mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23262664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00125-012-2802-Z

1 reference

Europe PubMed Central

30 May 2018

http://europepmc.org/abstract/MED/23262664

1 reference

Europe PubMed Central

30 May 2018

http://europepmc.org/abstract/MED/23262664

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