cJUN N-terminal kinase (JNK) activation mediates islet amyloid-induced beta cell apoptosis in cultured human islet amyloid polypeptide transgenic mouse islets. (Q35646939)

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scientific article published on 26 October 2011

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English	cJUN N-terminal kinase (JNK) activation mediates islet amyloid-induced beta cell apoptosis in cultured human islet amyloid polypeptide transgenic mouse islets.	scientific article published on 26 October 2011

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cJUN N-terminal kinase (JNK) activation mediates islet amyloid-induced beta cell apoptosis in cultured human islet amyloid polypeptide transgenic mouse islets (English)

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Kathryn Aston-Mourney

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S L Subramanian

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R L Hull

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S Zraika

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J Udayasankar

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26 October 2011

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https://scigraph.springernature.com/pub.10.1007/s00125-011-2338-7

0 references

β-cell loss and β-cell apoptosis in human type 2 diabetes are related to islet amyloid deposition

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12 July 2018

Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan

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12 July 2018

Involvement of mitochondrial dysfunction in human islet amyloid polypeptide-induced apoptosis in INS-1E pancreatic beta cells: An effect attenuated by phycocyanin

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Modulation of Bcl-2-related protein expression in pancreatic beta cells by pro-inflammatory cytokines and its dependence on the antioxidative defense status.

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12 July 2018

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

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12 July 2018

Differences between amyloid toxicity in alpha and beta cells in human and mouse islets and the role of caspase-3.

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12 July 2018

Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax.

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12 July 2018

Bad news for beta-cell apoptosis.

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12 July 2018

Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stress

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12 July 2018

Cytokine-mediated induction of anti-apoptotic genes that are linked to nuclear factor kappa-B (NF-kappaB) signalling in human islets and in a mouse beta cell line

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12 July 2018

Beta cell apoptosis in diabetes

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12 July 2018

Oxidative stress is induced by islet amyloid formation and time-dependently mediates amyloid-induced beta cell apoptosis

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12 July 2018

Initiation and execution of lipotoxic ER stress in pancreatic beta-cells

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12 July 2018

Fas-associated death receptor signaling evoked by human amylin in islet beta-cells

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12 July 2018

Induction of endoplasmic reticulum stress-induced beta-cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptide

1 reference

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12 July 2018

High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249975

12 July 2018

Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

1 reference

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12 July 2018

Glucose- and time-dependence of islet amyloid formation in vitro

1 reference

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12 July 2018

Role of JNK activation in apoptosis: a double-edged sword

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Adult neuron survival strategies--slamming on the brakes

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12 July 2018

Islet amyloid: a critical entity in the pathogenesis of type 2 diabetes

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12 July 2018

Fibrillogenic amylin evokes islet beta-cell apoptosis through linked activation of a caspase cascade and JNK1.

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12 July 2018

Increased expression and activation of c-Jun contributes to human amylin-induced apoptosis in pancreatic islet beta-cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249975

12 July 2018

Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets

1 reference

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12 July 2018

Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients.

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Interleukin-1beta stimulation of c-Jun NH(2)-terminal kinase activity in insulin-secreting cells: evidence for cytoplasmic restriction

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12 July 2018

Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death

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12 July 2018

beta-cell glucokinase deficiency and hyperglycemia are associated with reduced islet amyloid deposition in a mouse model of type 2 diabetes

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12 July 2018

The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic beta-cells

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12 July 2018

Induction of apoptosis by human amylin in RINm5F islet beta-cells is associated with enhanced expression of p53 and p21WAF1/CIP1.

1 reference

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12 July 2018

The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles.

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12 July 2018

Different sensitivity to the cytotoxic action of IAPP fibrils in two insulin-producing cell lines, HIT-T15 and RINm5F cells

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12 July 2018

Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus

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12 July 2018

Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients

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12 July 2018

Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells

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Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation

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12 July 2018

The influence of amyloid deposits on the islet volume in maturity onset diabetes mellitus

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12 July 2018

Islet graft response to transplantation injury includes upregulation of protective as well as apoptotic genes

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25 September 2018

Phycocyanin protects INS-1E pancreatic beta cells against human islet amyloid polypeptide-induced apoptosis through attenuating oxidative stress and modulating JNK and p38 mitogen-activated protein kinase pathways.

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Glucose and leptin induce apoptosis in human beta-cells and impair glucose-stimulated insulin secretion through activation of c-Jun N-terminal kinases

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25 September 2018

Oxidative stress, ER stress, and the JNK pathway in type 2 diabetes

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25 September 2018

Inhibitors can arrest the membrane activity of human islet amyloid polypeptide independently of amyloid formation

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25 September 2018

Pancreatic expression and secretion of human islet amyloid polypeptide in a transgenic mouse.

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25 September 2018

JNK3 is abundant in insulin-secreting cells and protects against cytokine-induced apoptosis

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21 January 2018

Intracellular Stress Signaling Pathways Activated During Human Islet Preparation and Following Acute Cytokine Exposure

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21 January 2018

Evidence of cosecretion of islet amyloid polypeptide and insulin by beta-cells

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12 December 2020

based on heuristic

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Pore formation by the cytotoxic islet amyloid peptide amylin

1 reference

https://pubmed.ncbi.nlm.nih.gov/22038516

12 December 2020

based on heuristic

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10.1007/S00125-011-2338-7

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15 January 2020

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15 January 2020

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