Functional Relevance of Improbable Antibody Mutations for HIV Broadly Neutralizing Antibody Development. (Q55356257)

3 July 2018

title

Functional Relevance of Improbable Antibody Mutations for HIV Broadly Neutralizing Antibody Development. (English)

1 reference

3 July 2018

12

Barton F Haynes

1 reference

3 July 2018

11

Mattia Bonsignori

1 reference

3 July 2018

Munir Alam

10

S Munir Alam

1 reference

3 July 2018

David Easterhoff

6

David Easterhoff

1 reference

3 July 2018

Kevin Wiehe

1

Kevin Wiehe

1 reference

3 July 2018

Wilton B Williams

5

Wilton B Williams

1 reference

3 July 2018

Todd Bradley

2

1 reference

3 July 2018

R Ryan Meyerhoff

3

1 reference

3 July 2018

Connor Hart

4

1 reference

3 July 2018

William J Faison

7

1 reference

3 July 2018

Thomas B Kepler

8

1 reference

3 July 2018

Kevin O Saunders

9

1 reference

3 July 2018

publication date

31 May 2018

1 reference

3 July 2018

published in

Cell Host & Microbe

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3 July 2018

volume

23

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3 July 2018

issue

6

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3 July 2018

page(s)

759-765.e6

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3 July 2018

Sequence intrinsic somatic mutation mechanisms contribute to affinity maturation of VRC01-class HIV-1 broadly neutralizing antibodies

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Composition and Antigenic Effects of Individual Glycan Sites of a Trimeric HIV-1 Envelope Glycoprotein

10 July 2018

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Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody

10 July 2018

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Visualizing antibody affinity maturation in germinal centers

10 July 2018

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Sequence-Intrinsic Mechanisms that Target AID Mutational Outcomes on Antibody Genes

10 July 2018

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HIV-1 VACCINES. Diversion of HIV-1 vaccine-induced immunity by gp41-microbiota cross-reactive antibodies

10 July 2018

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10 July 2018

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CATNAP: a tool to compile, analyze and tally neutralizing antibody panels

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6002614

Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6002614

Ability to develop broadly neutralizing HIV-1 antibodies is not restricted by the germline Ig gene repertoire

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6002614

Dynamics of B cells in germinal centres

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6002614

Immunoglobulin gene insertions and deletions in the affinity maturation of HIV-1 broadly reactive neutralizing antibodies

10 July 2018

1 reference

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Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies

10 July 2018

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Immunologic Basis for Long HCDR3s in Broadly Neutralizing Antibodies Against HIV-1.

10 July 2018

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Early development of broadly neutralizing antibodies in HIV-1-infected infants

10 July 2018

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Reconstructing a B-Cell Clonal Lineage. II. Mutation, Selection, and Affinity Maturation

10 July 2018

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10 July 2018

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Antibodies VRC01 and 10E8 neutralize HIV-1 with high breadth and potency even with Ig-framework regions substantially reverted to germline

10 July 2018

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10 July 2018

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Models of somatic hypermutation targeting and substitution based on synonymous mutations from high-throughput immunoglobulin sequencing data

10 July 2018

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Optimization and validation of the TZM-bl assay for standardized assessments of neutralizing antibodies against HIV-1.

10 July 2018

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10 July 2018

1 reference

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Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies

10 July 2018

1 reference

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Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

10 July 2018

1 reference

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Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization

10 July 2018

1 reference

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Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6002614

Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2

10 July 2018

1 reference

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Antigenicity and immunogenicity of RV144 vaccine AIDSVAX clade E envelope immunogen is enhanced by a gp120 N-terminal deletion

10 July 2018

1 reference

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Selection pressure on HIV-1 envelope by broadly neutralizing antibodies to the conserved CD4-binding site

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6002614

Two distinct broadly neutralizing antibody specificities of different clonal lineages in a single HIV-1-infected donor: implications for vaccine design

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6002614

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6002614

Generation of transmitted/founder HIV-1 infectious molecular clones and characterization of their replication capacity in CD4 T lymphocytes and monocyte-derived macrophages

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6002614

H3N2 influenza infection elicits more cross-reactive and less clonally expanded anti-hemagglutinin antibodies than influenza vaccination

10 July 2018

1 reference

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10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6002614

Polyclonal B cell responses to conserved neutralization epitopes in a subset of HIV-1-infected individuals

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6002614

Analysis of a clonal lineage of HIV-1 envelope V2/V3 conformational epitope-specific broadly neutralizing antibodies and their inferred unmutated common ancestors

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6002614

Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding

10 July 2018

1 reference

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The neutralization breadth of HIV-1 develops incrementally over four years and is associated with CD4+ T cell decline and high viral load during acute infection

10 July 2018

1 reference

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Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01

10 July 2018

1 reference

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Tiered categorization of a diverse panel of HIV-1 Env pseudoviruses for assessment of neutralizing antibodies

10 July 2018

1 reference

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Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand

10 July 2018

1 reference

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Immunoglobulin somatic hypermutation

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6002614

Molecular mechanisms of antibody somatic hypermutation.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6002614

Genetic and neutralization properties of subtype C human immunodeficiency virus type 1 molecular env clones from acute and early heterosexually acquired infections in Southern Africa

10 July 2018

1 reference

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Human immunodeficiency virus type 1 env clones from acute and early subtype B infections for standardized assessments of vaccine-elicited neutralizing antibodies

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6002614

Variants from the diverse virus population identified at seroconversion of a clade A human immunodeficiency virus type 1-infected woman have distinct biological properties

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6002614

Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6002614

Stepwise intraclonal maturation of antibody affinity through somatic hypermutation

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6002614

Intraclonal generation of antibody mutants in germinal centres

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6002614

Immunologic memory to phosphocholine keyhole limpet hemocyanin. Recurrent mutations in the lambda 1 light chain increase affinity for antigen.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6002614

Dual infection of the central nervous system by AIDS viruses with distinct cellular tropisms.

10 July 2018

1 reference

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Developing an HIV vaccine

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6002614

Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6002614

The nucleotide-replacement spectrum under somatic hypermutation exhibits microsequence dependence that is strand-symmetric and distinct from that under germline mutation

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6002614

Monitoring and interpreting the intrinsic features of somatic hypermutation

12 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29861171

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CHOM.2018.04.018

1 reference

3 July 2018

PMC publication ID

6002614

1 reference

3 July 2018

PubMed publication ID

29861171

1 reference

3 July 2018