The 1.5 Å Crystal Structure of a Prokaryote Serpin (Q56338497)

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object named as

Stephen P. Bottomley

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author name string

James A. Irving

1

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Lisa D. Cabrita

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Robert N. Pike

4

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James C. Whisstock

Phylogeny of the serpin superfamily: implications of patterns of amino acid conservation for structure and function.

6

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language of work or name

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April 2003

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published in

Structure

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volume

11

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issue

4

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page(s)

387-397

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cites work

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7 January 2021

The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature

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7 January 2021

Cross-class inhibition of the cysteine proteinases cathepsins K, L, and S by the serpin squamous cell carcinoma antigen 1: a kinetic analysis

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7 January 2021

Ovalbumin and angiotensinogen lack serpin S-R conformational change

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7 January 2021

Crystal structure of uncleaved ovalbumin at 1.95 A resolution

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7 January 2021

Conformational changes in serpins: I. The native and cleaved conformations of alpha(1)-antitrypsin

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7 January 2021

The pH dependence of serpin-proteinase complex dissociation reveals a mechanism of complex stabilization involving inactive and active conformational states of the proteinase which are perturbable by calcium

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7 January 2021

Intrinsic fluorescence changes and rapid kinetics of proteinase deformation during serpin inhibition

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7 January 2021

Serpin-protease complexes are trapped as stable acyl-enzyme intermediates

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7 January 2021

Structure of a serpin-protease complex shows inhibition by deformation

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7 January 2021

Heterogeneity in serpin-protease complexes as demonstrated by differences in the mechanism of complex breakdown

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7 January 2021

Implications of the three-dimensional structure of alpha 1-antitrypsin for structure and function of serpins

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7 January 2021

Principles that govern the folding of protein chains

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7 January 2021

The F-helix of serpins plays an essential, active role in the proteinase inhibition mechanism

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7 January 2021

Structural basis of latency in plasminogen activator inhibitor-1

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The 2.6 A structure of antithrombin indicates a conformational change at the heparin binding site

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Biological implications of a 3 A structure of dimeric antithrombin

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The intact and cleaved human antithrombin III complex as a model for serpin-proteinase interactions

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7 January 2021

The anticoagulant activation of antithrombin by heparin

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Conformational changes in serpins: II. The mechanism of activation of antithrombin by heparin.

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7 January 2021

Conformation of the reactive site loop of alpha 1-proteinase inhibitor probed by limited proteolysis

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7 January 2021

Pathogenic α1-Antitrypsin Polymers Are Formed by Reactive Loop-β-Sheet A Linkage

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7 January 2021

A 2.6 A structure of a serpin polymer and implications for conformational disease

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7 January 2021

Cleaved antitrypsin polymers at atomic resolution

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7 January 2021

The mechanism of Z alpha 1-antitrypsin accumulation in the liver

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7 January 2021

Effect of the Z mutation on the physical and inhibitory properties of alpha 1-antitrypsin

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Plasminogen-activator inhibitor type 2 (PAI-2) is a spontaneously polymerising SERPIN. Biochemical characterisation of the recombinant intracellular and extracellular forms

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Molecular and structural characterization of the heat-resistant thyroxine-binding globulin-Chicago

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Identification of positively charged residues contributing to the stability of plasminogen activator inhibitor 1

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Formation and properties of C1-inhibitor polymers

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7 January 2021

Serpins in prokaryotes

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Cultural, morphological, and physiological characteristics of Thermomonospora fusca (strain 190Th)

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Thermoanaerobacter tengcongensis sp. nov., a novel anaerobic, saccharolytic, thermophilic bacterium isolated from a hot spring in Tengcong, China

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Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum aerophilum

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Effects of mutations in the hinge region of serpins

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Thromboembolic disease due to thermolabile conformational changes of antithrombin Rouen-VI (187 Asn-->Asp)

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7 January 2021

Partitioning of serpin-proteinase reactions between stable inhibition and substrate cleavage is regulated by the rate of serpin reactive center loop insertion into beta-sheet A.

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7 January 2021

Mechanism of serpin action: evidence that C1 inhibitor functions as a suicide substrate

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Regulation of protein function by native metastability

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Alkaline serine proteinase from Thermomonospora fusca YX. Stability to heat and denaturants

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A Kinetic Mechanism for the Polymerization of α1-Antitrypsin

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How do thermophilic proteins deal with heat?

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Protein thermostability in extremophiles

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Elucidation of factors responsible for enhanced thermal stability of proteins: a structural genomics based study

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Factors enhancing protein thermostability

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Conformational Studies on Plasminogen Activator Inhibitor (PAI-1) in Active, Latent, Substrate, and Cleaved Forms

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7 January 2021

Crystal structure of the apoptotic suppressor CrmA in its cleaved form

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7 January 2021

Crystal structure of viral serpin crmA provides insights into its mechanism of cysteine proteinase inhibition

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7 January 2021

Characterization and functional analysis of Serp3: a novel myxoma virus-encoded serpin involved in virulence.

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7 January 2021

Probing the equilibrium denaturation of the serpin alpha(1)-antitrypsin with single tryptophan mutants; evidence for structure in the urea unfolded state

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7 January 2021

The effects of reactive centre loop length upon serpin polymerisation

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7 January 2021

The Z type variation of human alpha 1-antitrypsin causes a protein folding defect

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Three-state unfolding and self-association of maspin, a tumor-suppressing serpin

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Probing the unfolding pathway of alpha1-antitrypsin.

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Conformational change and intermediates in the unfolding of alpha 1-antichymotrypsin

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Conformational disease

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Alpha1-antitrypsin deficiency--a model for conformational diseases

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The serpin inhibitory mechanism is critically dependent on the length of the reactive center loop

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Evidence that serpin architecture intrinsically supports papain-like cysteine protease inhibition: engineering alpha(1)-antitrypsin to inhibit cathepsin proteases

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The Protein Data Bank

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MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

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Raster3D: photorealistic molecular graphics

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