Structure and Modeling of GPCRs: Implications for Drug Discovery (Q57015852)

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Screening the receptorome: an efficient approach for drug discovery and target validation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Heavier-than-air flying machines are impossible.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Focused library design in GPCR projects on the example of 5-HT(2c) agonists: comparison of structure-based virtual screening with ligand-based search methods

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Virtual screening of biogenic amine-binding G-protein coupled receptors: comparative evaluation of protein- and ligand-based virtual screening protocols

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Optimal bundling of transmembrane helices using sparse distance constraints

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

PREDICT modeling and in-silico screening for G-protein coupled receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Prediction of structure and function of G protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Structure modeling of all identified G protein-coupled receptors in the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Crystal structure of the human beta2 adrenergic G-protein-coupled receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Structure of a beta1-adrenergic G-protein-coupled receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Insights into signaling from the β2-adrenergic receptor structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic Receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Separating model optimization and model validation in statistical cross-validation as applied to crystallography

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Crystallographic refinement of ligand complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

NQ-Flipper: recognition and correction of erroneous asparagine and glutamine side-chain rotamers in protein structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Analysis of full and partial agonists binding to beta2-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Biased probability Monte Carlo conformational searches and electrostatic calculations for peptides and proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Conformational states and dynamics of rhodopsin in micelles and bilayers

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Use of an in situ disulfide cross-linking strategy to study the dynamic properties of the cytoplasmic end of transmembrane domain VI of the M3 muscarinic acetylcholine receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Crystal structure of a photoactivated deprotonated intermediate of rhodopsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Crystal packing analysis of Rhodopsin crystals

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Q-Dock: Low-resolution flexible ligand docking with pocket-specific threading restraints

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Lessons in molecular recognition: the effects of ligand and protein flexibility on molecular docking accuracy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Flexible ligand docking to multiple receptor conformations: a practical alternative

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

ICM?A new method for protein modeling and design: Applications to docking and structure prediction from the distorted native conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Detailed ab initio prediction of lysozyme–antibody complex with 1.6 Å accuracy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Protein flexibility in ligand docking and virtual screening to protein kinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Discovery of antiandrogen activity of nonsteroidal scaffolds of marketed drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Discovery of novel chemotypes to a G-protein-coupled receptor through ligand-steered homology modeling and structure-based virtual screening.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

GPCR 3D homology models for ligand screening: lessons learned from blind predictions of adenosine A2a receptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

G protein coupled receptor structure and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Activation of G protein-coupled receptors: beyond two-state models and tertiary conformational changes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Crystal structure of the ligand-free G-protein-coupled receptor opsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Selective structure-based virtual screening for full and partial agonists of the beta2 adrenergic receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

The forgotten serine. A critical role for Ser-2035.42 in ligand binding to and activation of the beta 2-adrenergic receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Synergistic contributions of the functional groups of epinephrine to its affinity and efficacy at the beta2 adrenergic receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

A new method for ligand docking to flexible receptors by dual alanine scanning and refinement (SCARE).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Protein-based virtual screening of chemical databases. II. Are homology models of G-Protein Coupled Receptors suitable targets?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Identifying conformational changes of the beta(2) adrenoceptor that enable accurate prediction of ligand/receptor interactions and screening for GPCR modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

The prediction and orientation of α-helices from sequence alignments: the combined use of environment-dependent substitution tables, Fourier transform methods and helix capping rules

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Predicted 3D structure for the human beta 2 adrenergic receptor and its binding site for agonists and antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

The predicted 3D structure of the human D2 dopamine receptor and the binding site and binding affinities for agonists and antagonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

G protein-coupled receptors: in silico drug discovery in 3D.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Predictions of CCR1 chemokine receptor structure and BX 471 antagonist binding followed by experimental validation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Membrane protein structure: prediction versus reality.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Assessment of CASP7 structure predictions for template free targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

First principles predictions of the structure and function of g-protein-coupled receptors: validation for bovine rhodopsin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

TASSER: an automated method for the prediction of protein tertiary structures in CASP6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Crystal structure of rhodopsin: A G protein-coupled receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Structure of bovine rhodopsin in a trigonal crystal form.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Crystal structure of squid rhodopsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Crystal Structure of a Thermally Stable Rhodopsin Mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Homology modeling of G-protein-coupled receptors and implications in drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Pocketome via comprehensive identification and classification of ligand binding envelopes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

On the applicability of GPCR homology models to computer-aided drug discovery: a comparison between in silico and crystal structures of the beta2-adrenergic receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

The second extracellular loop of the dopamine D2 receptor lines the binding-site crevice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Loopholes and missing links in protein modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Ab initio computational modeling of loops in G-protein-coupled receptors: lessons from the crystal structure of rhodopsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Ab initio computational modeling of long loops in G-protein coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Structure-based identification of binding sites, native ligands and potential inhibitors for G-protein coupled receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Molecular modeling of the second extracellular loop of G-protein coupled receptors and its implication on structure-based virtual screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Molecular recognition of opioid receptor ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Homology modeling of the serotonin 5-HT1A receptor using automated docking of bioactive compounds with defined geometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

GLIDA: GPCR--ligand database for chemical genomics drug discovery--database and tools update

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

DrugBank: a knowledgebase for drugs, drug actions and drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

GPCR structure-based virtual screening approach for CB2 antagonist search

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Successful virtual screening for a submicromolar antagonist of the neurokinin-1 receptor based on a ligand-supported homology model

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Molecular modeling of the three-dimensional structure of dopamine 3 (D3) subtype receptor: discovery of novel and potent D3 ligands through a hybrid pharmacophore- and structure-based database searching approach.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

The 7 TM G-protein-coupled receptor target family

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Molecular characterization of the human beta 3-adrenergic receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Differential contribution of two serine residues of wild type and constitutively active beta2-adrenoceptors to the interaction with beta2-selective agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Pyrazolo-triazolo-pyrimidines as adenosine receptor antagonists: A complete structure-activity profile

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Adenosine receptors as therapeutic targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Conformational changes in G-protein-coupled receptors-the quest for functionally selective conformations is open

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Ligand-selective receptor conformations revisited: the promise and the problem

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Molecular mechanism of 7TM receptor activation--a global toggle switch model

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Conformational complexity of G-protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Crystal structure of opsin in its G-protein-interacting conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Beta2 adrenergic receptor activation. Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Structural mimicry in class A G protein-coupled receptor rotamer toggle switches: the importance of the F3.36(201)/W6.48(357) interaction in cannabinoid CB1 receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Location of Trp265 in metarhodopsin II: implications for the activation mechanism of the visual receptor rhodopsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Inactive and active states and supramolecular organization of GPCRs: insights from computational modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Contributions of intracellular loops 2 and 3 of the lutropin receptor in Gs coupling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Mechanisms of inter- and intramolecular communication in GPCRs and G proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

A concept for G protein activation by G protein-coupled receptor dimers: the transducin/rhodopsin interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Complexing receptor pharmacology: modulation of family B G protein-coupled receptor function by RAMPs

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

A day in the life of a G protein-coupled receptor: the contribution to function of G protein-coupled receptor dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Efficient coupling of transducin to monomeric rhodopsin in a phospholipid bilayer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

GPCR monomers and oligomers: it takes all kinds

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

The G protein-coupled receptor rhodopsin in the native membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Old and new ways to calculate the affinity of agonists and antagonists interacting with G-protein-coupled monomeric and dimeric receptors: the receptor-dimer cooperativity index.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

G-protein-coupled receptor heteromers: function and ligand pharmacology

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Pattern of intra-family hetero-oligomerization involving the G-protein-coupled secretin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Dimerization of the lutropin receptor: insights from computational modeling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Quaternary structure predictions of transmembrane proteins starting from the monomer: a docking-based approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Dark and photoactivated rhodopsin share common binding modes to transducin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

A functional transmembrane complex: the luteinizing hormone receptor with bound ligand and G protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Molecular modeling and mutagenesis of gap junction channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Computational prediction of atomic structures of helical membrane proteins aided by EM maps.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

GPCR agonists and antagonists in the clinic

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Structural diversity of G protein-coupled receptors and significance for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Allosteric modulation of G protein-coupled receptors: perspectives and recent developments

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Allosteric agonists of 7TM receptors: expanding the pharmacological toolbox

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

NMR structure and peptide hormone binding site of the first extracellular domain of a type B1 G protein-coupled receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Molecular recognition of parathyroid hormone by its G protein-coupled receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Role of lysine187 within the second extracellular loop of the type A cholecystokinin receptor in agonist-induced activation. Use of complementary charge-reversal mutagenesis to define a functionally important interdomain interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Spatial approximation between secretin residue five and the third extracellular loop of its receptor provides new insight into the molecular basis of natural agonist binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Fluorescence resonance energy transfer analysis of secretin docking to its receptor: mapping distances between residues distributed throughout the ligand pharmacophore and distinct receptor residues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Molecular approximations between residues 21 and 23 of secretin and its receptor: development of a model for peptide docking with the amino terminus of the secretin receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Design and synthesis of a series of non-peptide high-affinity human corticotropin-releasing factor1 receptor antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

1-Alkyl-3-amino-5-aryl-1H-[1,2,4]triazoles: novel synthesis via cyclization of N-acyl-S-methylisothioureas with alkylhydrazines and their potent corticotropin-releasing factor-1 (CRF(1)) receptor antagonist activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Optimization of 3-phenylpyrazolo[1,5-a]pyrimidines as potent corticotropin-releasing factor-1 antagonists with adequate lipophilicity and water solubility

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Allosteric ligands for the corticotropin releasing factor type 1 receptor modulate conformational states involved in receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Design and synthesis of 3-(2-pyridyl)pyrazolo[1,5-a]pyrimidines as potent CRF1 receptor antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Substituted tetraazaacenaphthylenes as potent CRF1 receptor antagonists for the treatment of depression and anxiety

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

High-affinity CRF1 receptor antagonist NBI-34041: preclinical and clinical data suggest safety and efficacy in attenuating elevated stress response

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

The gene repertoire and the common evolutionary history of glutamate, pheromone (V2R), taste(1) and other related G protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Allosteric modulators of group I metabotropic glutamate receptors: novel subtype-selective ligands and therapeutic perspectives.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Therapeutic potential of group III metabotropic glutamate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Metabotropic glutamate receptors as drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

The calcimimetic cinacalcet normalizes serum calcium in subjects with primary hyperparathyroidism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Structural views of the ligand-binding cores of a metabotropic glutamate receptor complexed with an antagonist and both glutamate and Gd3+.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Structures of the extracellular regions of the group II/III metabotropic glutamate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Comparative analysis of the ligand-binding sites of the metabotropic glutamate receptors mGluR1-mGluR8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Activation of family C G-protein-coupled receptors by the tripeptide glutathione

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Synthesis, molecular modeling studies, and preliminary pharmacological characterization of all possible 2-(2'-sulfonocyclopropyl)glycine stereoisomers as conformationally constrained L-homocysteic acid analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

[3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Mutational Analysis and Molecular Modeling of the Binding Pocket of the Metabotropic Glutamate 5 Receptor Negative Modulator 2-Methyl-6-(phenylethynyl)-pyridine

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Comparison of the binding pockets of two chemically unrelated allosteric antagonists of the mGlu5 receptor and identification of crucial residues involved in the inverse agonism of MPEP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Determination of key amino acids implicated in the actions of allosteric modulation by 3,3'-difluorobenzaldazine on rat mGlu5 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Calindol, a positive allosteric modulator of the human Ca(2+) receptor, activates an extracellular ligand-binding domain-deleted rhodopsin-like seven-transmembrane structure in the absence of Ca(2+).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

An automated system for the analysis of G protein-coupled receptor transmembrane binding pockets: alignment, receptor-based pharmacophores, and their application.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Homology model-based virtual screening for GPCR ligands using docking and target-biased scoring.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Preferential binding of allosteric modulators to active and inactive conformational states of metabotropic glutamate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Virtual screen for ligands of orphan G protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Critical Role for the Second Extracellular Loop in the Binding of Both Orthosteric and Allosteric G Protein-coupled Receptor Ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15

Rhodopsin dimers in native disc membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F9780470627327.CH15