Pyrrolidine Dithiocarbamate Inhibits Interleukin-6 Signaling through Impaired STAT3 Activation and Association with Transcriptional Coactivators in Hepatocytes (Q57372526)

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scientific article published in Journal of Biological Chemistry

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English	Pyrrolidine Dithiocarbamate Inhibits Interleukin-6 Signaling through Impaired STAT3 Activation and Association with Transcriptional Coactivators in Hepatocytes	scientific article published in Journal of Biological Chemistry

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29 December 2019

Pyrrolidine dithiocarbamate inhibits interleukin-6 signaling through impaired STAT3 activation and association with transcriptional coactivators in hepatocytes (English)

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Hua-Jun He

1

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Tie-Nian Zhu

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Yi Xie

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Jinshui Fan

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Sutapa Kole

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Satya Saxena

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22 August 2006

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Journal of Biological Chemistry

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31369-31379

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29 December 2019

STATs and gene regulation

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Lack of gp130 expression in hepatocytes promotes liver injury1 1K.L.S. and T.W. contributed equally to this work

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Haptoglobin, an inflammation-inducible plasma protein

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Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3

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Oxidative stress triggers STAT3 tyrosine phosphorylation and nuclear translocation in human lymphocytes

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Distinct regulation of the interleukin-1 and interleukin-6 response elements of the rat haptoglobin gene in rat and human hepatoma cells

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Interactions of STAT3 with caveolin-1 and heat shock protein 90 in plasma membrane raft and cytosolic complexes. Preservation of cytokine signaling during fever

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Involvement of heat-shock protein 90 in the interleukin-6-mediated signaling pathway through STAT3.

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Cloning and characterization of a functional promoter of the human SOCS-3 gene

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Interleukin-6 induces cellular insulin resistance in hepatocytes

1 reference

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21 January 2018

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21 January 2018

Pyrrolidine dithiocarbamate provides protection against hypothermic preservation and transplantation injury in the rat liver: the role of heme oxygenase-1.

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Identifiers

10.1074/JBC.M603762200

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29 December 2019

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Europe PubMed Central

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29 December 2019

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