Antibody-mediated protection against Ebola virus (Q58375648)

inferred from title

author

Erica Ollmann Saphire

object named as

Erica Ollmann Saphire

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Bronwyn M Gunn

3

object named as

Bronwyn M. Gunn

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Galit Alter

5

object named as

Galit Alter

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author name string

Sharon L. Schendel

2

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Jacob C. Milligan

Next generation antibody drugs: pursuit of the 'high-hanging fruit'.

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language of work or name

English

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publication date

17 October 2018

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November 2018

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published in

Nature Immunology

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volume

19

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issue

11

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page(s)

1169-1178

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cites work

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A Randomized, Controlled Trial of ZMapp for Ebola Virus Infection

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Harnessing Fc receptor biology in the design of therapeutic antibodies

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Boosting ADCC and CDC activity by Fc engineering and evaluation of antibody effector functions

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The role of Fc-FcγR interactions in IgG-mediated microbial neutralization

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Role of Fc-mediated antibody function in protective immunity against HIV-1.

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Genetic variation of human neutrophil Fcγ receptors and SIRPα in antibody-dependent cellular cytotoxicity towards cancer cells.

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Utilizing complement evasion strategies to design complement-based antibacterial immunotherapeutics: Lessons from the pathogenic Neisseriae

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Broadly neutralizing anti-HIV-1 antibodies require Fc effector functions for in vivo activity

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7 January 2021

Progress and Challenges in the Design and Clinical Development of Antibodies for Cancer Therapy.

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7 January 2021

Systematic Analysis of Monoclonal Antibodies against Ebola Virus GP Defines Features that Contribute to Protection

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7 January 2021

Ebola virus can be effectively neutralized by antibody produced in natural human infection

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7 January 2021

Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor

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7 January 2021

Pre- and postexposure prophylaxis of Ebola virus infection in an animal model by passive transfer of a neutralizing human antibody

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Neutralizing antibody fails to impact the course of Ebola virus infection in monkeys

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7 January 2021

Postexposure antibody prophylaxis protects nonhuman primates from filovirus disease.

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Ebola GP-specific monoclonal antibodies protect mice and guinea pigs from lethal Ebola virus infection

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7 January 2021

Structures of protective antibodies reveal sites of vulnerability on Ebola virus

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7 January 2021

Delayed treatment of Ebola virus infection with plant-derived monoclonal antibodies provides protection in rhesus macaques

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7 January 2021

Therapeutic intervention of Ebola virus infection in rhesus macaques with the MB-003 monoclonal antibody cocktail

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7 January 2021

Structures of Ebola virus GP and sGP in complex with therapeutic antibodies

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7 January 2021

Epitopes involved in antibody-mediated protection from Ebola virus

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7 January 2021

Mechanism of Binding to Ebola Virus Glycoprotein by the ZMapp, ZMAb, and MB-003 Cocktail Antibodies

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7 January 2021

Biochemical and structural characterization of cathepsin L-processed Ebola virus glycoprotein: implications for viral entry and immunogenicity

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7 January 2021

Role of endosomal cathepsins in entry mediated by the Ebola virus glycoprotein

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7 January 2021

Enhanced potency of a fucose-free monoclonal antibody being developed as an Ebola virus immunoprotectant

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7 January 2021

Generation of glyco-engineered Nicotiana benthamiana for the production of monoclonal antibodies with a homogeneous human-like N-glycan structure

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7 January 2021

Natural variation in Fc glycosylation of HIV-specific antibodies impacts antiviral activity

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7 January 2021

Antigen-Specific Antibody Glycosylation Is Regulated via Vaccination

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7 January 2021

Agalactosylated IgG antibodies depend on cellular Fc receptors for in vivo activity.

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7 January 2021

The impact of glycosylation on the biological function and structure of human immunoglobulins.

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7 January 2021

The role of differential IgG glycosylation in the interaction of antibodies with FcγRs in vivo

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7 January 2021

Glycosylation of recombinant antibody therapeutics

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7 January 2021

Development of a pre-glycoengineered CHO-K1 host cell line for the expression of antibodies with enhanced Fc mediated effector function.

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7 January 2021

Advances in the assessment and control of the effector functions of therapeutic antibodies

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7 January 2021

Improved effector functions of a therapeutic monoclonal Lewis Y-specific antibody by glycoform engineering

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7 January 2021

Production of therapeutic antibodies with controlled fucosylation

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7 January 2021

Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp

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7 January 2021

Protective monotherapy against lethal Ebola virus infection by a potently neutralizing antibody

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7 January 2021

Development of Clinical-Stage Human Monoclonal Antibodies That Treat Advanced Ebola Virus Disease in Nonhuman Primates

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7 January 2021

How to turn competitors into collaborators

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7 January 2021

Generation of biologically contained Ebola viruses

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7 January 2021

A forward genetic strategy reveals destabilizing mutations in the Ebolavirus glycoprotein that alter its protease dependence during cell entry

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7 January 2021

Systems serology for evaluation of HIV vaccine trials

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7 January 2021

CD107a as a functional marker for the identification of natural killer cell activity.

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7 January 2021

Antibody-mediated neutralization of Ebola virus can occur by two distinct mechanisms

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7 January 2021

Mechanism of human antibody-mediated neutralization of Marburg virus

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7 January 2021

The Marburgvirus-Neutralizing Human Monoclonal Antibody MR191 Targets a Conserved Site to Block Virus Receptor Binding

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7 January 2021

Structural basis for Marburg virus neutralization by a cross-reactive human antibody

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7 January 2021

Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection

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7 January 2021

Ebola virus entry requires the host-programmed recognition of an intracellular receptor

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7 January 2021

Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection

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7 January 2021

Proteolysis of the Ebola virus glycoproteins enhances virus binding and infectivity

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7 January 2021

Antigenic subversion: a novel mechanism of host immune evasion by Ebola virus

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7 January 2021

Structural basis of potent Zika–dengue virus antibody cross-neutralization

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7 January 2021

A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins

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Cross-neutralization of four paramyxoviruses by a human monoclonal antibody

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7 January 2021

Identification of human neutralizing antibodies that bind to complex epitopes on dengue virions

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7 January 2021

Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth.

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7 January 2021

Antibody responses to envelope glycoproteins in HIV-1 infection

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7 January 2021

Immunology and evolvement of the adenovirus prime, MVA boost Ebola virus vaccine

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7 January 2021

Chimpanzee adenovirus vaccine generates acute and durable protective immunity against ebolavirus challenge

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7 January 2021

Mucosal immunization of cynomolgus macaques with the VSVDeltaG/ZEBOVGP vaccine stimulates strong ebola GP-specific immune responses

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7 January 2021

Different features of Vδ2 T and NK cells in fatal and non-fatal human Ebola infections

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7 January 2021

Mechanisms of anaphylaxis in human low-affinity IgG receptor locus knock-in mice.

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7 January 2021

Contribution of Human FcγRs to Disease with Evidence from Human Polymorphisms and Transgenic Animal Studies

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7 January 2021

Mouse model recapitulating human Fcγ receptor structural and functional diversity

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7 January 2021

Fcgamma receptors as regulators of immune responses

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7 January 2021

Characterization of monoclonal antibody glycosylation: comparison of expression systems and identification of terminal alpha-linked galactose

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7 January 2021

Metabolic control of recombinant monoclonal antibody N-glycosylation in GS-NS0 cells

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7 January 2021

Metabolic control of recombinant protein N-glycan processing in NS0 and CHO cells

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7 January 2021

A Role for Fc Function in Therapeutic Monoclonal Antibody-Mediated Protection against Ebola Virus

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7 January 2021

Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human Fcgamma RIII and antibody-dependent cellular toxicity

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7 January 2021

Identification of antibody glycosylation structures that predict monoclonal antibody Fc-effector function

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7 January 2021

Correction: Antigen-Specific Antibody Glycosylation Is Regulated via Vaccination

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7 January 2021

Considering aspects of the 3Rs principles within experimental animal biology.

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7 January 2021

Isotype and glycoform selection for antibody therapeutics

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7 January 2021

Fc receptor but not complement binding is important in antibody protection against HIV.

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7 January 2021

Antibody-mediated coengagement of FcγRIIb and B cell receptor complex suppresses humoral immunity in systemic lupus erythematosus

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7 January 2021

Reduction of total IgE by targeted coengagement of IgE B-cell receptor and FcγRIIb with Fc-engineered antibody

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7 January 2021

Biological significance of carbohydrate chains on monoclonal antibodies

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7 January 2021

Effector functions of a monoclonal aglycosylated mouse IgG2a: binding and activation of complement component C1 and interaction with human monocyte Fc receptor

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7 January 2021

A Review of Obinutuzumab (GA101), a Novel Type II Anti-CD20 Monoclonal Antibody, for the Treatment of Patients with B-Cell Malignancies

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7 January 2021

Marketing approval of mogamulizumab: a triumph for glyco-engineering

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7 January 2021

Obinutuzumab: a review of its use in patients with chronic lymphocytic leukaemia

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7 January 2021

Benralizumab--a humanized mAb to IL-5Rα with enhanced antibody-dependent cell-mediated cytotoxicity--a novel approach for the treatment of asthma

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7 January 2021

Engineered antibody Fc variants with enhanced effector function

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7 January 2021

Complement is activated by IgG hexamers assembled at the cell surface

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7 January 2021

High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R.

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7 January 2021

Fc optimization of therapeutic antibodies enhances their ability to kill tumor cells in vitro and controls tumor expansion in vivo via low-affinity activating Fcgamma receptors

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7 January 2021

Optimization of antibody binding to FcgammaRIIa enhances macrophage phagocytosis of tumor cells

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7 January 2021

The Fc-engineered CD19 antibody MOR208 (XmAb5574) induces natural killer cell-mediated lysis of acute lymphoblastic leukemia cells from pediatric and adult patients

1 reference

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7 January 2021

The impact of Fc engineering on an anti-CD19 antibody: increased Fcgamma receptor affinity enhances B-cell clearing in nonhuman primates

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7 January 2021

A phase 1 dose-escalation study of XmAb® 2513 in patients with relapsed or refractory Hodgkin lymphoma

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7 January 2021

Efficacy of an Fc-modified anti-CD123 antibody (CSL362) combined with chemotherapy in xenograft models of acute myelogenous leukemia in immunodeficient mice

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7 January 2021

Dual functional monoclonal antibody PF-04605412 targets integrin alpha5beta1 and elicits potent antibody-dependent cellular cytotoxicity

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7 January 2021

A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface

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7 January 2021

Properties of human IgG1s engineered for enhanced binding to the neonatal Fc receptor (FcRn).

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7 January 2021

pH-dependent binding engineering reveals an FcRn affinity threshold that governs IgG recycling

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7 January 2021

Safety, Tolerability, and Pharmacokinetics of MEDI4893, an Investigational, Extended-Half-Life, Anti-Staphylococcus aureus Alpha-Toxin Human Monoclonal Antibody, in Healthy Adults

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7 January 2021

Safety and pharmacokinetics of the Fc-modified HIV-1 human monoclonal antibody VRC01LS: A Phase 1 open-label clinical trial in healthy adults.

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7 January 2021

Beyond Viral Neutralization

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7 January 2021

Immune correlates of vaccine protection against HIV-1 acquisition

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7 January 2021

Both Neutralizing and Non-Neutralizing Human H7N9 Influenza Vaccine-Induced Monoclonal Antibodies Confer Protection

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7 January 2021

Protective capacity of neutralizing and non-neutralizing antibodies against glycoprotein B of cytomegalovirus.

1 reference

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7 January 2021

Non-neutralizing Antibodies Alter the Course of HIV-1 Infection In Vivo

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7 January 2021

Complex of a Protective Antibody with Its Ebola Virus GP Peptide Epitope: Unusual Features of a Vλx Light Chain

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7 January 2021

Structural and molecular basis for Ebola virus neutralization by protective human antibodies

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7 January 2021

GA-101, a third-generation, humanized and glyco-engineered anti-CD20 mAb for the treatment of B-cell lymphoid malignancies

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12 December 2020

Successful treatment of ebola virus-infected cynomolgus macaques with monoclonal antibodies

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12 December 2020

humanized mice to study FcγR function

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12 December 2020

Fc receptor-dependent mechanisms of monoclonal antibody therapy of cancer

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12 December 2020

Molecular characterization of the monoclonal antibodies composing ZMAb: a protective cocktail against Ebola virus

1 reference

12 December 2020

Antibody-dependent-cellular-cytotoxicity-inducing antibodies significantly affect the post-exposure treatment of Ebola virus infection

1 reference

12 December 2020