Systemic autophagy insufficiency compromises adaptation to metabolic stress and facilitates progression from obesity to diabetes (Q59516123)

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20 February 2020

title

Systemic autophagy insufficiency compromises adaptation to metabolic stress and facilitates progression from obesity to diabetes (English)

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20 February 2020

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7

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20 February 2020

Seung-Hoi Koo

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20 February 2020

Masaaki Komatsu

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20 February 2020

author name string

Yu-Mi Lim

1

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20 February 2020

Hyejin Lim

2

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20 February 2020

Kyu Yeon Hur

3

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20 February 2020

Wenying Quan

4

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20 February 2020

Hae-Youn Lee

5

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20 February 2020

Hwanju Cheon

6

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20 February 2020

Hong Lim Kim

9

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20 February 2020

Jin Kim

10

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20 February 2020

Myung-Shik Lee

12

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20 February 2020

language of work or name

English

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publication date

26 September 2014

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20 February 2020

published in

Nature Communications

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20 February 2020

volume

5

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20 February 2020

issue

1

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page(s)

4934

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https://scigraph.springernature.com/pub.10.1038/ncomms5934

20 February 2020

exact match

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cites work

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Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet

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Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia

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Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice

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Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis

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Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

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Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

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Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism

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7 January 2021

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Imatinib mesylate reduces endoplasmic reticulum stress and induces remission of diabetes in db/db mice

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Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB

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7 January 2021

Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action

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7 January 2021

Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates

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Autophagy suppresses tumorigenesis through elimination of p62

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p53 Activation in Adipocytes of Obese Mice

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Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence

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7 January 2021

Autophagy regulates lipid metabolism

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7 January 2021

Generation of cell lines with tetracycline-regulated autophagy and a role for autophagy in controlling cell size.

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7 January 2021

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production

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7 January 2021

A role for mitochondria in NLRP3 inflammasome activation

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7 January 2021

Adipocyte death, adipose tissue remodeling, and obesity complications

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The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

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Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells

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Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation

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7 January 2021

Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.

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7 January 2021

Altered lipid content inhibits autophagic vesicular fusion

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7 January 2021

LC3, a microtubule-associated protein1A/B light chain3, is involved in cytoplasmic lipid droplet formation

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7 January 2021

Autophagy deficiency in beta cells leads to compromised unfolded protein response and progression from obesity to diabetes in mice

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7 January 2021

Autophagy deficiency by hepatic FIP200 deletion uncouples steatosis from liver injury in NAFLD.

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Loss of autophagy in pro-opiomelanocortin neurons perturbs axon growth and causes metabolic dysregulation

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7 January 2021

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7 January 2021

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mTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes

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7 January 2021

Amyloidogenic peptide oligomer accumulation in autophagy-deficient β cells induces diabetes

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Understanding oral glucose tolerance: comparison of glucose or insulin measurements during the oral glucose tolerance test with specific measurements of insulin resistance and insulin secretion.

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Lysophosphatidylcholine as an effector of fatty acid-induced insulin resistance

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TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver

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Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells

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Resistance of mitochondrial DNA-depleted cells against cell death: role of mitochondrial superoxide dismutase

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Cellular aging of mitochondrial DNA-depleted cells

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Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans

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7 January 2021

Identifiers

DOI

10.1038/NCOMMS5934

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25255859%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

0 references

1 reference