Interferon regulatory factor 3 (Q5973468)

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mammalian protein found in Homo sapiens
  • uniprot:Q14653
  • IRF3
  • interferon regulatory factor 3
edit
Language Label Description Also known as
English
Interferon regulatory factor 3
mammalian protein found in Homo sapiens
  • uniprot:Q14653
  • IRF3
  • interferon regulatory factor 3

Statements

molecular function
protein binding
determination method
IPI
17 references
retrieved
8 April 2019
stated in
C6orf106 is a novel inhibitor of the interferon-regulatory factor 3-dependent innate antiviral response
GOA
curator
UniProt
UniProt protein ID
Q14653
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IPI
retrieved
8 April 2019
stated in
TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity
GOA
curator
UniProt
UniProt protein ID
Q14653
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IPI
retrieved
8 April 2019
stated in
Tetraspanin 6 (TSPAN6) negatively regulates retinoic acid-inducible gene I-like receptor-mediated immune signaling in a ubiquitination-dependent manner
GOA
curator
UniProt
UniProt protein ID
Q14653
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IPI
retrieved
8 April 2019
stated in
Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3
GOA
curator
UniProt
UniProt protein ID
Q14653
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IPI
retrieved
8 April 2019
stated in
Positive regulation of interferon regulatory factor 3 activation by Herc5 via ISG15 modification
GOA
curator
UniProt
UniProt protein ID
Q14653
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IPI
retrieved
8 April 2019
stated in
Crystal structure of IRF-3 in complex with CBP.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IPI
retrieved
8 April 2019
stated in
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IPI
retrieved
8 April 2019
stated in
The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IPI
retrieved
8 April 2019
stated in
The transcription factor MafB antagonizes antiviral responses by blocking recruitment of coactivators to the transcription factor IRF3
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IPI
retrieved
8 April 2019
stated in
Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IPI
retrieved
8 April 2019
stated in
S-glutathionylation of IRF3 regulates IRF3-CBP interaction and activation of the IFN beta pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IPI
retrieved
8 April 2019
stated in
Interaction between the HCV NS3 protein and the host TBK1 protein leads to inhibition of cellular antiviral responses
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IPI
retrieved
8 April 2019
stated in
The GRIP1:IRF3 interaction as a target for glucocorticoid receptor-mediated immunosuppression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IPI
retrieved
8 April 2019
stated in
Ebola virus protein VP35 impairs the function of interferon regulatory factor-activating kinases IKKepsilon and TBK-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IPI
retrieved
8 April 2019
stated in
RIOK3 is an adaptor protein required for IRF3-mediated antiviral type I interferon production
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IPI
retrieved
8 April 2019
stated in
Structural Insights into the Functions of TBK1 in Innate Antimicrobial Immunity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IPI
identical protein binding
determination method
IEA
IPI
14 references
retrieved
1 January 2018
stated in
ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IPI
retrieved
1 January 2018
stated in
MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IPI
retrieved
1 January 2018
stated in
Structural basis for suppression of a host antiviral response by influenza A virus
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IPI
retrieved
1 January 2018
stated in
The transcription factor MafB antagonizes antiviral responses by blocking recruitment of coactivators to the transcription factor IRF3
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IPI
retrieved
1 January 2018
stated in
Structural Insights into the Functions of TBK1 in Innate Antimicrobial Immunity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IPI
retrieved
1 January 2018
stated in
Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IPI
retrieved
1 January 2018
stated in
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IPI
retrieved
1 January 2018
stated in
Interaction between the HCV NS3 protein and the host TBK1 protein leads to inhibition of cellular antiviral responses
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IPI
retrieved
1 January 2018
stated in
Activation of STAT6 by STING is critical for antiviral innate immunity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IPI
retrieved
1 January 2018
stated in
Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IPI
retrieved
1 January 2018
stated in
Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IPI
retrieved
1 January 2018
stated in
Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IPI
retrieved
1 January 2018
stated in
ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IPI
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IEA
identical protein binding
determination method
IPI
13 references
retrieved
8 April 2019
stated in
Structural basis for suppression of a host antiviral response by influenza A virus
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IPI
retrieved
8 April 2019
stated in
Activation of STAT6 by STING is critical for antiviral innate immunity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IPI
retrieved
8 April 2019
stated in
MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IPI
retrieved
8 April 2019
stated in
The transcription factor MafB antagonizes antiviral responses by blocking recruitment of coactivators to the transcription factor IRF3
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IPI
retrieved
8 April 2019
stated in
ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IPI
retrieved
8 April 2019
stated in
Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IPI
retrieved
8 April 2019
stated in
Interaction between the HCV NS3 protein and the host TBK1 protein leads to inhibition of cellular antiviral responses
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IPI
retrieved
8 April 2019
stated in
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IPI
retrieved
8 April 2019
stated in
ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IPI
retrieved
8 April 2019
stated in
Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IPI
retrieved
8 April 2019
stated in
Structural Insights into the Functions of TBK1 in Innate Antimicrobial Immunity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IPI
retrieved
8 April 2019
stated in
Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IPI
retrieved
8 April 2019
stated in
Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653
determination method
IPI
cell component
biological process
Gene Atlas image
PBB GE IRF3 202621 at fs.png
732 × 530; 12 KB
0 references

Identifiers

RefSeq protein ID
Ensembl protein ID
PDB structure ID
 
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