Current state of Alzheimer's fluid biomarkers (Q60310921)

Michelle M Mielke

9

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Harald Hampel

8

Harald Hampel

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Henrik Zetterberg

18

Henrik Zetterberg

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Kaj Blennow

19

Kaj Blennow

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Anne M Fagan

7

Anne M Fagan

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Jeffrey L. Cummings

6

Jeffrey Cummings

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John Q. Trojanowski

17

John Q Trojanowski

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author name string

José Luis Molinuevo

1

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Scott Ayton

2

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Richard Batrla

3

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Martin M Bednar

4

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Tobias Bittner

5

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Alvydas Mikulskis

10

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Sid O'Bryant

11

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Jeffrey Sevigny

13

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Leslie M Shaw

14

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Holly D Soares

15

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Gary Tong

Creative Commons Attribution 4.0 International

16

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language of work or name

English

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publication date

December 2018

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1 December 2018

1 reference

19 November 2020

Acta Neuropathologica

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19 November 2020

136

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issue

6

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page(s)

821-853

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copyright license

1 reference

Europe PubMed Central

Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

19 November 2020

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Plasma Abeta(1-40) and Abeta(1-42) and the risk of dementia: a prospective case-cohort study.

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Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

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IP-10 serum levels are not increased in mild cognitive impairment and Alzheimer's disease.

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TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease

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Longitudinal stability of CSF biomarkers in Alzheimer's disease.

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A systematic review and meta-analysis of CSF neurofilament protein levels as biomarkers in dementia.

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Serum heart-type fatty acid-binding protein and cerebrospinal fluid tau: marker candidates for dementia with Lewy bodies

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CSF tau/Abeta42 ratio for increased risk of mild cognitive impairment: a follow-up study

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Loss of synaptophysin and synaptosomal-associated protein 25-kDa (SNAP-25) in elderly Down syndrome individuals.

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Intra-individual stability of CSF biomarkers for Alzheimer's disease over two years.

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Increased CSF-BACE 1 activity is associated with ApoE-epsilon 4 genotype in subjects with mild cognitive impairment and Alzheimer's disease

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Detection of elevated levels of α-synuclein oligomers in CSF from patients with Parkinson disease.

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YKL-40: a novel prognostic fluid biomarker for preclinical Alzheimer's disease

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Abnormal neurites containing C-terminally truncated alpha-synuclein are present in Alzheimer's disease without conventional Lewy body pathology.

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Qualification of the analytical and clinical performance of CSF biomarker analyses in ADNI.

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Neurofilaments at a glance

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Heart-type fatty acid binding protein and vascular endothelial growth factor: cerebrospinal fluid biomarker candidates for Alzheimer's disease.

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α-Synuclein in cerebrospinal fluid of Alzheimer's disease and mild cognitive impairment

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Dual cleavage of neuregulin 1 type III by BACE1 and ADAM17 liberates its EGF-like domain and allows paracrine signaling.

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Cerebrospinal fluid Aβ1-40 improves differential dementia diagnosis in patients with intermediate P-tau181P levels

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CSF α-synuclein improves diagnostic and prognostic performance of CSF tau and Aβ in Alzheimer's disease

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The future of blood-based biomarkers for Alzheimer's disease

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A delicate balance: Iron metabolism and diseases of the brain.

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Identification of an important potential confound in CSF AD studies: aliquot volume

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Association of cerebrospinal fluid β-amyloid 1-42, T-tau, P-tau181, and α-synuclein levels with clinical features of drug-naive patients with early Parkinson disease

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Increased expression of TREM2 in peripheral blood of Alzheimer's disease patients.

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Heart fatty acid binding protein and Aβ-associated Alzheimer's neurodegeneration

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Characterization of novel CSF Tau and ptau biomarkers for Alzheimer's disease

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The diagnostic value of CSF amyloid-β(43) in differentiation of dementia syndromes.

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12 December 2020

Characterization of intermediate steps in amyloid beta (Aβ) production under near-native conditions

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12 December 2020

Cerebrospinal fluid BACE1 activity and markers of amyloid precursor protein metabolism and axonal degeneration in Alzheimer's disease

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12 December 2020

Perspective on future role of biological markers in clinical therapy trials of Alzheimer's disease: a long-range point of view beyond 2020.

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12 December 2020

The diagnostic value of CSF α-synuclein in the differential diagnosis of dementia with Lewy bodies vs. normal subjects and patients with Alzheimer's disease

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Plasma phosphorylated TDP-43 levels are elevated in patients with frontotemporal dementia carrying a C9orf72 repeat expansion or a GRN mutation

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Increased CSF α-synuclein levels in Alzheimer's disease: correlation with tau levels

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Increased α-synuclein levels in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease

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Clinical utility of cerebrospinal fluid biomarkers in the diagnosis of early Alzheimer's disease

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Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria

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Levels of cerebrospinal fluid α-synuclein oligomers are increased in Parkinson's disease with dementia and dementia with Lewy bodies compared to Alzheimer's disease

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12 December 2020

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12 December 2020

Plasma Aβ but not tau is related to brain PiB retention in early Alzheimer's disease

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12 December 2020

Evaluation of Visinin-Like Protein 1 Concentrations in the Cerebrospinal Fluid of Patients with Mild Cognitive Impairment as a Dynamic Biomarker of Alzheimer's Disease

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12 December 2020

Increased Levels of Chitotriosidase and YKL-40 in Cerebrospinal Fluid from Patients with Alzheimer's Disease

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12 December 2020

Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer's disease research

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CSF neurofilament light differs in neurodegenerative diseases and predicts severity and survival

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12 December 2020

Improving CSF Biomarkers' Performance for Predicting Progression from Mild Cognitive Impairment to Alzheimer's Disease by Considering Different Confounding Factors: A Meta-Analysis

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12 December 2020

Cerebrospinal fluid biomarkers distinguish postmortem-confirmed Alzheimer's disease from other dementias and healthy controls in the OPTIMA cohort.

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12 December 2020

Oligomeric Aβ-induced synaptic dysfunction in Alzheimer's disease

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12 December 2020

SNAP-25 is a promising novel cerebrospinal fluid biomarker for synapse degeneration in Alzheimer's disease

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12 December 2020

The triggering receptor expressed on myeloid cells 2 (TREM2) is associated with enhanced inflammation, neuropathological lesions and increased risk for Alzheimer's dementia

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12 December 2020

Vascular contributions to cognitive impairment and dementia including Alzheimer's disease

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12 December 2020

Mechanism of Oxidative Stress and Synapse Dysfunction in the Pathogenesis of Alzheimer's Disease: Understanding the Therapeutics Strategies

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12 December 2020

Cerebrospinal fluid levels of the synaptic protein neurogranin correlates with cognitive decline in prodromal Alzheimer's disease.

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12 December 2020

Alpha-synuclein biology in Lewy body diseases

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12 December 2020

Spreading of pathology in neurodegenerative diseases: a focus on human studies

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12 December 2020

Microglia and neuroprotection

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12 December 2020

Soluble BACE-1 Activity and sAβPPβ Concentrations in Alzheimer's Disease and Age-Matched Healthy Control Cerebrospinal Fluid from the Alzheimer's Disease Neuroimaging Initiative-1 Baseline Cohort.

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12 December 2020

A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid

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12 December 2020

CSF biomarkers for the differential diagnosis of Alzheimer's disease: A large-scale international multicenter study.

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12 December 2020

TDP-43 as a possible biomarker for frontotemporal lobar degeneration: a systematic review of existing antibodies

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12 December 2020

Relationship between cortical thickness and cerebrospinal fluid YKL-40 in predementia stages of Alzheimer's disease

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12 December 2020

Cerebrospinal Fluid Markers of Neurodegeneration and Rates of Brain Atrophy in Early Alzheimer Disease

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12 December 2020

Neurofilament light chain: A prognostic biomarker in amyotrophic lateral sclerosis.

1 reference

12 December 2020

Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE

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12 December 2020

The Role of TDP-43 in Alzheimer's Disease

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12 December 2020

C-terminal neurogranin is increased in cerebrospinal fluid but unchanged in plasma in Alzheimer's disease

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12 December 2020

Characterization of the postsynaptic protein neurogranin in paired cerebrospinal fluid and plasma samples from Alzheimer's disease patients and healthy controls

1 reference

12 December 2020

Pre-analytical and analytical factors influencing Alzheimer's disease cerebrospinal fluid biomarker variability

1 reference

12 December 2020

Serum Fragments of Tau for the Differential Diagnosis of Alzheimer's Disease.

1 reference

12 December 2020

Amyloid precursor protein metabolism and inflammation markers in preclinical Alzheimer disease

1 reference

12 December 2020

Chasing the Effects of Pre-Analytical Confounders - A Multicenter Study on CSF-AD Biomarkers

1 reference

12 December 2020

Application of Systems Theory in Longitudinal Studies on the Origin and Progression of Alzheimer's Disease

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12 December 2020

A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome

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12 December 2020

Enduring Elevations of Hippocampal Amyloid Precursor Protein and Iron Are Features of β-Amyloid Toxicity and Are Mediated by Tau

1 reference

12 December 2020

The Inflammatory Marker YKL-40 Is Elevated in Cerebrospinal Fluid from Patients with Alzheimer's but Not Parkinson's Disease or Dementia with Lewy Bodies

1 reference

12 December 2020

Does neuroinflammation turn on the flame in Alzheimer's disease? Focus on astrocytes

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12 December 2020

YKL-40/CHI3L1 drives inflammation on the road of tumor progression

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12 December 2020

Vascular dysfunction in the pathogenesis of Alzheimer's disease--A review of endothelium-mediated mechanisms and ensuing vicious circles

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12 December 2020

TREM2 mRNA Expression in Leukocytes Is Increased in Alzheimer's Disease and Schizophrenia

1 reference

12 December 2020

Detailed comparison of amyloid PET and CSF biomarkers for identifying early Alzheimer disease

1 reference

12 December 2020

Neurogranin as a Cerebrospinal Fluid Biomarker for Synaptic Loss in Symptomatic Alzheimer Disease

1 reference

12 December 2020

Cerebrospinal fluid neurogranin: relation to cognition and neurodegeneration in Alzheimer's disease

1 reference

12 December 2020

Fluid Biomarkers in Clinical Trials of Alzheimer's Disease Therapeutics

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12 December 2020

Tauopathies as clinicopathological entities

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12 December 2020

Cerebrospinal fluid VILIP-1 and YKL-40, candidate biomarkers to diagnose, predict and monitor Alzheimer's disease in a memory clinic cohort

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12 December 2020

The Role of Visinin-Like Protein-1 in the Pathophysiology of Alzheimer's Disease

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12 December 2020

Elevation of the Plasma Aβ40/Aβ42 Ratio as a Diagnostic Marker of Sporadic Early-Onset Alzheimer's Disease.

1 reference

12 December 2020

Association of Cerebrospinal Fluid Neurofilament Light Concentration With Alzheimer Disease Progression

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12 December 2020

Sorting out release, uptake and processing of alpha-synuclein during prion-like spread of pathology

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12 December 2020

Cerebrospinal Fluid Aβ40 Improves the Interpretation of Aβ42 Concentration for Diagnosing Alzheimer's Disease

1 reference

12 December 2020

Identifying amyloid pathology-related cerebrospinal fluid biomarkers for Alzheimer's disease in a multicohort study

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12 December 2020

Neurogranin and YKL-40: independent markers of synaptic degeneration and neuroinflammation in Alzheimer's disease

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12 December 2020

Tau Biology and Tau-Directed Therapies for Alzheimer's Disease

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12 December 2020

Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer's disease

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12 December 2020

Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status

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12 December 2020

Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson's disease

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Single-Molecule Imaging of Individual Amyloid Protein Aggregates in Human Biofluids

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Metals and Neuronal Metal Binding Proteins Implicated in Alzheimer's Disease

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sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers

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Cerebrospinal fluid ratios with Aβ42 predict preclinical brain β-amyloid accumulation

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Diagnostic and Prognostic Utility of the Synaptic Marker Neurogranin in Alzheimer Disease

1 reference

12 December 2020

CSF biomarkers associated with disease heterogeneity in early Parkinson's disease: the Parkinson's Progression Markers Initiative study

1 reference

12 December 2020

The amyloid hypothesis of Alzheimer's disease at 25 years

1 reference

12 December 2020

CSF Aβ42/Aβ40 and Aβ42/Aβ38 ratios: better diagnostic markers of Alzheimer disease

1 reference

12 December 2020

Plasma neurofilament light chain predicts progression in progressive supranuclear palsy

1 reference

12 December 2020

CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis

1 reference

12 December 2020

Cerebrospinal fluid soluble TREM2 in aging and Alzheimer's disease

1 reference

12 December 2020

Plasma soluble neuregulin-1 as a diagnostic biomarker for Alzheimer's disease

1 reference

12 December 2020

Physiological and pathological roles of the γ-secretase complex

1 reference

12 December 2020

Methods for the Specific Detection and Quantitation of Amyloid-β Oligomers in Cerebrospinal Fluid

1 reference

12 December 2020

Neuroinflammation in Alzheimer's disease: Current evidence and future directions

1 reference

12 December 2020

1 reference

12 December 2020

The γ-Secretase Modulator, BMS-932481, Modulates Aβ Peptides in the Plasma and Cerebrospinal Fluid of Healthy Volunteers

1 reference

12 December 2020

Cerebrospinal Fluid TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis Patients with and without the C9ORF72 Hexanucleotide Expansion

1 reference

12 December 2020

The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy

1 reference

12 December 2020

CSF Aβ1-42 - an excellent but complicated Alzheimer's biomarker - a route to standardisation

1 reference

12 December 2020

Revolutionizing Alzheimer's disease and clinical trials through biomarkers

1 reference

12 December 2020

Plasma β-amyloid in Alzheimer's disease and vascular disease

1 reference

12 December 2020

High tau levels in cerebrospinal fluid predict nursing home placement and rapid progression in Alzheimer's disease

1 reference

12 December 2020

Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis

1 reference

12 December 2020

Synaptic degeneration and neurogranin in the pathophysiology of Alzheimer's disease

1 reference

12 December 2020

Non-Amyloid PET Imaging Biomarkers for Neurodegeneration: Focus on Tau, Alpha-Synuclein and Neuroinflammation

1 reference

12 December 2020

The Cerebrospinal Fluid Neurogranin/BACE1 Ratio is a Potential Correlate of Cognitive Decline in Alzheimer's Disease

1 reference

12 December 2020

Pittsburgh compound B imaging and cerebrospinal fluid amyloid-β in a multicentre European memory clinic study

1 reference

12 December 2020

Prediction of conversion from mild cognitive impairment to dementia with neuronally derived blood exosome protein profile

1 reference

12 December 2020

Cerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer's disease

1 reference

12 December 2020

Levels of tau protein in plasma are associated with neurodegeneration and cognitive function in a population-based elderly cohort.

1 reference

12 December 2020

Imaging synaptic density in the living human brain.

1 reference

12 December 2020

Estimation of Tau and Phosphorylated Tau181 in Serum of Alzheimer's Disease and Mild Cognitive Impairment Patients.

1 reference

12 December 2020

Cerebrospinal Fluid Biomarkers for Target Engagement and Efficacy in Clinical Trials for Alzheimer's and Parkinson's Diseases

1 reference

12 December 2020

Increased neurogranin concentrations in cerebrospinal fluid of Alzheimer's disease and in mild cognitive impairment due to AD.

1 reference

12 December 2020

Cerebrospinal fluid tau, neurogranin, and neurofilament light in Alzheimer's disease

1 reference

12 December 2020

Neurofilament light in CSF and serum is a sensitive marker for axonal white matter injury in MS.

1 reference

12 December 2020

Serum Neurofilament Light Protein as a Marker for Diffuse Axonal Injury: Results from a Case Series Study

1 reference

12 December 2020

2016 Alzheimer's disease facts and figures

1 reference

12 December 2020

Reference measurement procedure for CSF amyloid beta (Aβ)1-42 and the CSF Aβ1-42 /Aβ1-40 ratio - a cross-validation study against amyloid PET.

1 reference

12 December 2020

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

1 reference

12 December 2020

Decreased synaptic proteins in neuronal exosomes of frontotemporal dementia and Alzheimer's disease

1 reference

12 December 2020

Comprehensive Quantitative Profiling of Tau and Phosphorylated Tau Peptides in Cerebrospinal Fluid by Mass Spectrometry Provides New Biomarker Candidates

1 reference

12 December 2020

Alpha-synuclein measured in cerebrospinal fluid from patients with Alzheimer's disease, mild cognitive impairment, or healthy controls: a two year follow-up study

1 reference

12 December 2020

Alpha-Synuclein Oligomers-Neurotoxic Molecules in Parkinson's Disease and Other Lewy Body Disorders

1 reference

12 December 2020

Tau Rather than TDP-43 Proteins are Potential Cerebrospinal Fluid Biomarkers for Frontotemporal Lobar Degeneration Subtypes: A Pilot Study.

1 reference

12 December 2020

Non-Phosphorylated Tau as a Potential Biomarker of Alzheimer's Disease: Analytical and Diagnostic Characterization

1 reference

12 December 2020

Cerebrospinal Fluid Biomarkers for Alzheimer's Disease: A View of the Regulatory Science Qualification Landscape from the Coalition Against Major Diseases CSF Biomarker Team

1 reference

12 December 2020

Decreased IL-8 levels in CSF and serum of AD patients and negative correlation of MMSE and IL-1β.

1 reference

12 December 2020

TDP-43 stage, mixed pathologies, and clinical Alzheimer's-type dementia

1 reference

12 December 2020

Plasma tau in Alzheimer disease

1 reference

12 December 2020

Cerebrospinal fluid levels of neurofilament and tau correlate with brain atrophy in natalizumab-treated multiple sclerosis

1 reference

12 December 2020

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

1 reference

12 December 2020

The pre-synaptic vesicle protein synaptotagmin is a novel biomarker for Alzheimer's disease

1 reference

12 December 2020

Cerebrospinal Fluid Biomarkers for the Differential Diagnosis between Alzheimer's Disease and Frontotemporal Lobar Degeneration: Systematic Review, HSROC Analysis, and Confounding Factors

1 reference

12 December 2020

Colocalization of cerebral iron with Amyloid beta in Mild Cognitive Impairment

1 reference

12 December 2020

Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies.

1 reference

12 December 2020

Cerebrospinal fluid biomarkers as a measure of disease activity and treatment efficacy in relapsing-remitting multiple sclerosis.

1 reference

12 December 2020

Cerebrospinal Fluid Aβ42/40 Corresponds Better than Aβ42 to Amyloid PET in Alzheimer's Disease

1 reference

12 December 2020

Concomitant AD pathology affects clinical manifestation and survival in dementia with Lewy bodies

1 reference

12 December 2020

The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer's disease patients

1 reference

12 December 2020

Harnessing Cerebrospinal Fluid Biomarkers in Clinical Trials for Treating Alzheimer's and Parkinson's Diseases: Potential and Challenges

1 reference

12 December 2020

Targeting neuroinflammation in Alzheimer's disease

1 reference

12 December 2020

Pathological α-synuclein exacerbates the progression of Parkinson's disease through microglial activation

1 reference

12 December 2020

Blood-based biomarkers in Alzheimer disease: Current state of the science and a novel collaborative paradigm for advancing from discovery to clinic

1 reference

12 December 2020

Association of Cerebrospinal Fluid Ferritin Level With Preclinical Cognitive Decline in APOE-ε4 Carriers.

1 reference

12 December 2020

The blood brain barrier in Alzheimer's disease.

1 reference

12 December 2020

Tau Platelets Correlate with Regional Brain Atrophy in Patients with Alzheimer's Disease

1 reference

12 December 2020

Development of a Biochemical Diagnosis of Parkinson Disease by Detection of α-Synuclein Misfolded Aggregates in Cerebrospinal Fluid

1 reference

12 December 2020

Conflicting cerebrospinal fluid biomarkers and progression to dementia due to Alzheimer's disease

1 reference

12 December 2020

Genomic variants, genes, and pathways of Alzheimer's disease: An overview

1 reference

12 December 2020

Early changes in CSF sTREM2 in dominantly inherited Alzheimer's disease occur after amyloid deposition and neuronal injury

1 reference

12 December 2020

Hypoxia/ischemia activate processing of Amyloid Precursor Protein: impact of vascular dysfunction in the pathogenesis of Alzheimer's disease

1 reference

12 December 2020

Synergistic interaction between amyloid and tau predicts the progression to dementia

1 reference

12 December 2020

Increased levels of CSF total but not oligomeric or phosphorylated forms of alpha-synuclein in patients diagnosed with probable Alzheimer's disease

1 reference

12 December 2020

Plasma concentrations of free amyloid β cannot predict the development of Alzheimer's disease

1 reference

12 December 2020

Alzheimer disease in 2016: Putting AD treatments and biomarkers to the test.

1 reference

12 December 2020

Drugs in Clinical Trials for Alzheimer's Disease: The Major Trends

1 reference

12 December 2020

Non-Naturally Occurring Small Molecule Microtubule-Stabilizing Agents: A Potential Tactic for CNS-Directed Therapies

1 reference

12 December 2020

Mass-Spectrometry-Based Method To Quantify in Parallel Tau and Amyloid β 1-42 in CSF for the Diagnosis of Alzheimer's Disease

1 reference

12 December 2020

Serum neurofilament is associated with progression of brain atrophy and disability in early MS.

1 reference

12 December 2020

The APOE ε4 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer's disease but not those of sTREM2.

1 reference

12 December 2020

BACE1 Dynamics Upon Inhibition with a BACE Inhibitor and Correlation to Downstream Alzheimer's Disease Markers in Elderly Healthy Participants

1 reference

12 December 2020

The Multifaceted Role of SNARE Proteins in Membrane Fusion.

1 reference

12 December 2020

How to handle adsorption of cerebrospinal fluid amyloid β (1-42) in laboratory practice? Identifying problematic handlings and resolving the issue by use of the Aβ42/Aβ40 ratio

1 reference

12 December 2020

Two-level diagnostic classification using cerebrospinal fluid YKL-40 in Alzheimer's disease.

1 reference

12 December 2020

Cerebrospinal Fluid Aβ42/Aβ40 as a Means to Limiting Tube- and Storage-Dependent Pre-Analytical Variability in Clinical Setting.

1 reference

12 December 2020

Diagnostic function of the neuroinflammatory biomarker YKL-40 in Alzheimer's disease and other neurodegenerative diseases

1 reference

12 December 2020

A Precision Medicine Initiative for Alzheimer's disease: the road ahead to biomarker-guided integrative disease modeling

1 reference

12 December 2020

Validation of α-Synuclein as a CSF Biomarker for Sporadic Creutzfeldt-Jakob Disease

1 reference

12 December 2020

Chemically treated plasma Aβ is a potential blood-based biomarker for screening cerebral amyloid deposition

1 reference

12 December 2020

PRECISION MEDICINE - The Golden Gate for Detection, Treatment and Prevention of Alzheimer's Disease

1 reference

12 December 2020

Association of Plasma Neurofilament Light With Neurodegeneration in Patients With Alzheimer Disease

1 reference

12 December 2020

Increased Plasma Beta-Secretase 1 May Predict Conversion to Alzheimer's Disease Dementia in Individuals With Mild Cognitive Impairment

1 reference

12 December 2020

Blood-Based Oligomeric and Other Protein Variant Biomarkers to Facilitate Pre-Symptomatic Diagnosis and Staging of Alzheimer's Disease.

1 reference

12 December 2020

Neurofilaments and Neurofilament Proteins in Health and Disease

1 reference

12 December 2020

Alzheimer's Disease: Biomarkers in the Genome, Blood, and Cerebrospinal Fluid

1 reference

12 December 2020

Serum neurofilament light as a biomarker for mild traumatic brain injury in contact sports.

1 reference

12 December 2020

Plasma neurofilament light chain levels in Alzheimer's disease

1 reference

12 December 2020

Higher Peripheral TREM2 mRNA Levels Relate to Cognitive Deficits and Hippocampal Atrophy in Alzheimer's Disease and Amnestic Mild Cognitive Impairment.

1 reference

12 December 2020

Physiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2

1 reference

12 December 2020

Evolving Relevance of Neuroproteomics in Alzheimer's Disease.

1 reference

12 December 2020

Serum Neurofilament light: A biomarker of neuronal damage in multiple sclerosis

1 reference

12 December 2020

Diagnostic accuracy of CSF neurofilament light chain protein in the biomarker-guided classification system for Alzheimer's disease.

1 reference

12 December 2020

Tau/α-synuclein ratio and inflammatory proteins in Parkinson's disease: An exploratory study.

1 reference

12 December 2020

Plasma α-synuclein predicts cognitive decline in Parkinson's disease

1 reference

12 December 2020

Plasma Tau Association with Brain Atrophy in Mild Cognitive Impairment and Alzheimer's Disease

1 reference

12 December 2020

Molecular Pathogenesis of Alzheimer's Disease: An Update

1 reference

12 December 2020

CSF sAPPβ, YKL-40, and neurofilament light in frontotemporal lobar degeneration.

1 reference

12 December 2020

Discovery and Confirmation of Diagnostic Serum Lipid Biomarkers for Alzheimer's Disease Using Direct Infusion Mass Spectrometry

1 reference

12 December 2020

YKL-40 (Chitinase 3-like I) is expressed in a subset of astrocytes in Alzheimer's disease and other tauopathies

1 reference

12 December 2020

Neurofilament light protein in blood as a potential biomarker of neurodegeneration in Huntington's disease: a retrospective cohort analysis

1 reference

12 December 2020

Consensus guidelines for lumbar puncture in patients with neurological diseases

1 reference

12 December 2020

Serum Amino Acid Profiles in Normal Subjects and in Patients with or at Risk of Alzheimer Dementia

1 reference

12 December 2020

Phosphorylated neurofilament heavy chain: A biomarker of survival for C9ORF72-associated amyotrophic lateral sclerosis

1 reference

12 December 2020

Heart-type fatty acid binding protein is a sensitive biomarker for early AMI detection in troponin negative patients: a pilot study.

1 reference

12 December 2020

Association of Plasma Total Tau Level With Cognitive Decline and Risk of Mild Cognitive Impairment or Dementia in the Mayo Clinic Study on Aging

1 reference

12 December 2020

Association between cerebrospinal fluid and plasma neurodegeneration biomarkers with brain atrophy in Alzheimer's disease

1 reference

12 December 2020

Pharmacodynamic effects of daclizumab in the intrathecal compartment

1 reference

12 December 2020

Elevated plasma ferritin in elderly individuals with high neocortical amyloid-β load.

1 reference

12 December 2020

Cerebrospinal Fluid Aβ43 Is Reduced in Early-Onset Compared to Late-Onset Alzheimer's Disease, But Has Similar Diagnostic Accuracy to Aβ42.

1 reference

12 December 2020

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

1 reference

12 December 2020

Strategic roadmap for an early diagnosis of Alzheimer's disease based on biomarkers

1 reference

12 December 2020

Cerebrospinal Fluid Neurogranin as a Biomarker of Neurodegenerative Diseases: A Cross-Sectional Study

1 reference

12 December 2020

Amyloid β concentrations and stable isotope labeling kinetics of human plasma specific to central nervous system amyloidosis

1 reference

12 December 2020

Differential role of CSF fatty acid binding protein 3, α-synuclein, and Alzheimer's disease core biomarkers in Lewy body disorders and Alzheimer's dementia

1 reference

12 December 2020

TREM2 in Neurodegenerative Diseases

1 reference

12 December 2020

Peripheral inflammatory markers in Alzheimer's disease: a systematic review and meta-analysis of 175 studies

1 reference

12 December 2020

Quantification of plasma phosphorylated tau to use as a biomarker for brain Alzheimer pathology: pilot case-control studies including patients with Alzheimer's disease and down syndrome.

1 reference

12 December 2020

Evidence that iron accelerates Alzheimer's pathology: a CSF biomarker study.

1 reference

12 December 2020

Plasma amyloid β 42/40 ratios as biomarkers for amyloid β cerebral deposition in cognitively normal individuals

1 reference

12 December 2020

A 9-microRNA Signature in Serum Serves as a Noninvasive Biomarker in Early Diagnosis of Alzheimer's Disease

1 reference

12 December 2020

Distinct deposition of amyloid-β species in brains with Alzheimer's disease pathology visualized with MALDI imaging mass spectrometry

1 reference

12 December 2020

Alzheimer's disease drug development pipeline: 2017.

1 reference

12 December 2020

Serum neurofilament light in familial Alzheimer disease: A marker of early neurodegeneration

1 reference

12 December 2020

Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry

1 reference

12 December 2020

Circulating brain-enriched microRNAs as novel biomarkers for detection and differentiation of neurodegenerative diseases

1 reference

12 December 2020

Amyloid Network Topology Characterizes the Progression of Alzheimer's Disease During the Predementia Stages.

1 reference

12 December 2020

Clinical Development of Aducanumab, an Anti-Aβ Human Monoclonal Antibody Being Investigated for the Treatment of Early Alzheimer's Disease

1 reference

12 December 2020

Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation

1 reference

12 December 2020

Atraumatic versus conventional lumbar puncture needles: a systematic review and meta-analysis.

1 reference

12 December 2020

Oligomeric forms of amyloid-β protein in plasma as a potential blood-based biomarker for Alzheimer's disease

1 reference

12 December 2020

Assay of Plasma Phosphorylated Tau Protein (Threonine 181) and Total Tau Protein in Early-Stage Alzheimer's Disease.

1 reference

12 December 2020

High performance plasma amyloid-β biomarkers for Alzheimer's disease

1 reference

12 December 2020

Cerebrospinal Fluid and Plasma Levels of Inflammation Differentially Relate to CNS Markers of Alzheimer's Disease Pathology and Neuronal Damage

1 reference

12 December 2020

Precision pharmacology for Alzheimer's disease

1 reference

12 December 2020

Characterization and clinical use of inflammatory cerebrospinal fluid protein markers in Alzheimer's disease

1 reference

12 December 2020

Systems Biology Methods for Alzheimer's Disease Research Toward Molecular Signatures, Subtypes, and Stages and Precision Medicine: Application in Cohort Studies and Trials.

1 reference

12 December 2020

Blood-Based Biomarker Screening with Agnostic Biological Definitions for an Accurate Diagnosis Within the Dimensional Spectrum of Neurodegenerative Diseases.

1 reference

12 December 2020

Revolution of Alzheimer Precision Neurology Passageway of Systems Biology and Neurophysiology.

1 reference

12 December 2020

Longitudinal decreases in multiple cerebrospinal fluid biomarkers of neuronal injury in symptomatic late onset Alzheimer's disease.

1 reference

12 December 2020

1 reference

12 December 2020

Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated

1 reference

12 December 2020

Sex differences in Alzheimer disease — the gateway to precision medicine

1 reference

12 December 2020

Plasma Amyloid as Prescreener for the Earliest Alzheimer Pathological Changes

1 reference

12 December 2020

Blood-based biomarkers for Alzheimer disease: mapping the road to the clinic

1 reference

12 December 2020

Biomarker-guided classification scheme of neurodegenerative diseases.

1 reference

12 December 2020