Fungal secondary metabolism: regulation, function and drug discovery (Q64082826)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30531948%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

title

Fungal secondary metabolism: regulation, function and drug discovery (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30531948%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

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1

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13 April 2020

author name string

Nancy P Keller

series ordinal

1

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language of work or name

English

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publication date

1 March 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30531948%20AND%20SRC:MED&resulttype=core&format=json

Nature Reviews Microbiology

13 April 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30531948%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

volume

17

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13 April 2020

page(s)

167-180

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13 April 2020

issue

3

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https://scigraph.springernature.com/pub.10.1038/s41579-018-0121-1

13 April 2020

exact match

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Characterization of the biosynthetic gene cluster for the ribosomally synthesized cyclic peptide ustiloxin B in Aspergillus flavus

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Clustered pathway genes in aflatoxin biosynthesis

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Identification and characterization of the ergochrome gene cluster in the plant pathogenic fungus Claviceps purpurea

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7 January 2021

Identification and functional analysis of the aspergillic acid gene cluster in Aspergillus flavus.

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Translating biosynthetic gene clusters into fungal armor and weaponry

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Prototype of an intertwined secondary-metabolite supercluster

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7 January 2021

Accurate prediction of secondary metabolite gene clusters in filamentous fungi

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Transgenic rice plants expressing trichothecene 3-O-acetyltransferase show resistance to the Fusarium phytotoxin deoxynivalenol.

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7 January 2021

Fragmentation of an aflatoxin-like gene cluster in a forest pathogen

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Spatial and temporal control of fungal natural product synthesis

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Influence of Environmental Factors on the Production of Penitrems A-F by Penicillium crustosum

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One strain-many compounds (OSMAC) method for production of polyketides, azaphilones, and an isochromanone using the endophytic fungus Dothideomycete sp.

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7 January 2021

Regulation of Secondary Metabolism by the Velvet Complex Is Temperature-Responsive in Aspergillus

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7 January 2021

Temperature during conidiation affects stress tolerance, pigmentation, and trypacidin accumulation in the conidia of the airborne pathogen Aspergillus fumigatus

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7 January 2021

Low-volume toolbox for the discovery of immunosuppressive fungal secondary metabolites

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7 January 2021

A non-linear model for temperature-dependent sporulation and T-2 and HT-2 production of Fusarium langsethiae and Fusarium sporotrichioides.

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7 January 2021

SUB1 has photoreceptor dependent and independent functions in sexual development and secondary metabolism in Trichoderma reesei.

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7 January 2021

VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism

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7 January 2021

Role of the Alternaria alternata blue-light receptor LreA (white-collar 1) in spore formation and secondary metabolism

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7 January 2021

Functional and physical interaction of blue- and red-light sensors in Aspergillus nidulans.

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7 January 2021

Association of fungal secondary metabolism and sclerotial biology

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7 January 2021

Activation of Aflatoxin Biosynthesis Alleviates Total ROS in Aspergillus parasiticus.

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7 January 2021

Coupling of transcriptional response to oxidative stress and secondary metabolism regulation in filamentous fungi

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7 January 2021

Oxidative stress and carbon metabolism influence Aspergillus flavus transcriptome composition and secondary metabolite production

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7 January 2021

Regulation and Role of Fungal Secondary Metabolites.

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7 January 2021

Sequence-specific binding by Aspergillus nidulans AflR, a C6 zinc cluster protein regulating mycotoxin biosynthesis.

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7 January 2021

Identification of a 12-gene Fusaric Acid Biosynthetic Gene Cluster in Fusarium Species Through Comparative and Functional Genomics

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7 January 2021

A nonribosomal peptide synthetase-derived iron(III) complex from the pathogenic fungus Aspergillus fumigatus

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7 January 2021

Perturbations in small molecule synthesis uncovers an iron-responsive secondary metabolite network in Aspergillus fumigatus

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7 January 2021

Activation of a silent fungal polyketide biosynthesis pathway through regulatory cross talk with a cryptic nonribosomal peptide synthetase gene cluster

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7 January 2021

LaeA negatively regulates dothistromin production in the pine needle pathogen Dothistroma septosporum.

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7 January 2021

Discovery of McrA, a master regulator of Aspergillus secondary metabolism

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7 January 2021

Co-ordination between BrlA regulation and secretion of the oxidoreductase FmqD directs selective accumulation of fumiquinazoline C to conidial tissues in Aspergillus fumigatus

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7 January 2021

Accumulation of ergot alkaloids during conidiophore development in Aspergillus fumigatus

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7 January 2021

Epigenome manipulation as a pathway to new natural product scaffolds and their congeners

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7 January 2021

The initiation and pattern of spread of histone H4 acetylation parallel the order of transcriptional activation of genes in the aflatoxin cluster

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7 January 2021

Histone deacetylase activity regulates chemical diversity in Aspergillus

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7 January 2021

The chromatin code of fungal secondary metabolite gene clusters

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7 January 2021

Deletion of a Histone Acetyltransferase Leads to the Pleiotropic Activation of Natural Products in Metarhizium robertsii.

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7 January 2021

KdmB, a Jumonji Histone H3 Demethylase, Regulates Genome-Wide H3K4 Trimethylation and Is Required for Normal Induction of Secondary Metabolism in Aspergillus nidulans

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7 January 2021

Epigenetic remodeling of the fungal secondary metabolome

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7 January 2021

Large-scale metabolomics reveals a complex response of Aspergillus nidulans to epigenetic perturbation

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7 January 2021

Heterochromatic marks are associated with the repression of secondary metabolism clusters in Aspergillus nidulans

1 reference

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7 January 2021

Analysis of the global regulator Lae1 uncovers a connection between Lae1 and the histone acetyltransferase HAT1 in Fusarium fujikuroi.

1 reference

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7 January 2021

Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation

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7 January 2021

Microbial communication leading to the activation of silent fungal secondary metabolite gene clusters.

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7 January 2021

VeA and MvlA repression of the cryptic orsellinic acid gene cluster in Aspergillus nidulans involves histone 3 acetylation.

1 reference

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7 January 2021

A developmentally regulated gene cluster involved in conidial pigment biosynthesis in Aspergillus fumigatus.

1 reference

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7 January 2021

A cryptic pigment biosynthetic pathway uncovered by heterologous expression is essential for conidial development in Pestalotiopsis fici

1 reference

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7 January 2021

Synthesis and assembly of fungal melanin

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7 January 2021

A Multifunctional and Possible Skin UV Protectant, (3R)-5-Hydroxymellein, Produced by an Endolichenic Fungus Isolated from Parmotrema austrosinense

1 reference

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7 January 2021

Redox metabolites signal polymicrobial biofilm development via the NapA oxidative stress cascade in Aspergillus

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7 January 2021

Mediators of mutualistic microbe-microbe interactions

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7 January 2021

Friends or foes? Emerging insights from fungal interactions with plants.

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7 January 2021

Pathogenic fungus harbours endosymbiotic bacteria for toxin production

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7 January 2021

Symbiotic Cooperation in the Biosynthesis of a Phytotoxin

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7 January 2021

Ralstonia solanacearum lipopeptide induces chlamydospore development in fungi and facilitates bacterial entry into fungal tissues

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7 January 2021

NRPS-Derived Isoquinolines and Lipopetides Mediate Antagonism between Plant Pathogenic Fungi and Bacteria.

1 reference

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7 January 2021

A functional bikaverin biosynthesis gene cluster in rare strains of Botrytis cinerea is positively controlled by VELVET.

1 reference

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7 January 2021

Horizontal transfer and death of a fungal secondary metabolic gene cluster

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7 January 2021

Dentigerumycin: a bacterial mediator of an ant-fungus symbiosis

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7 January 2021

Secondary metabolites from Escovopsis weberi and their role in attacking the garden fungus of leaf cutting ants.

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7 January 2021

1 reference

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7 January 2021

Bacteria induce pigment formation in the basidiomycete Serpula lacrymans

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7 January 2021

Regulatory cascade and biological activity of Beauveria bassiana oosporein that limits bacterial growth after host death

1 reference

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7 January 2021

Balancing selection for aflatoxin in Aspergillus flavus is maintained through interference competition with, and fungivory by insects.

1 reference

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7 January 2021

Resistance is not futile: gliotoxin biosynthesis, functionality and utility.

1 reference

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7 January 2021

The transporter CefM involved in translocation of biosynthetic intermediates is essential for cephalosporin production.

1 reference

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7 January 2021

Transannular disulfide formation in gliotoxin biosynthesis and its role in self-resistance of the human pathogen Aspergillus fumigatus

1 reference

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7 January 2021

Effect of increased dosage of the ML-236B (compactin) biosynthetic gene cluster on ML-236B production in Penicillium citrinum

1 reference

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

7 January 2021

Resistance Gene-Guided Genome Mining: Serial Promoter Exchanges in Aspergillus nidulans Reveal the Biosynthetic Pathway for Fellutamide B, a Proteasome Inhibitor.

1 reference

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7 January 2021

Genomics-driven discovery of a novel self-resistance mechanism in the echinocandin-producing fungus Pezicula radicicola.

1 reference

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7 January 2021

Resistance-gene-directed discovery of a natural-product herbicide with a new mode of action

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7 January 2021

A new class of IMP dehydrogenase with a role in self-resistance of mycophenolic acid producing fungi

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7 January 2021

Biofilms and beyond: expanding echinocandin utility

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7 January 2021

Biosynthesis of fusarubins accounts for pigmentation of Fusarium fujikuroi perithecia

1 reference

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7 January 2021

Production of a fungal furocoumarin by a polyketide synthase gene cluster confers the chemo-resistance of Neurospora crassa to the predation by fungivorous arthropods.

1 reference

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7 January 2021

The polyketide synthase gene pks4 is essential for sexual development and regulates fruiting body morphology in Sordaria macrospora.

1 reference

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

7 January 2021

GKK1032A₂, a secondary metabolite from Penicillium sp. IBWF-029-96, inhibits conidial germination in the rice blast fungus Magnaporthe oryzae

1 reference

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

7 January 2021

Global analysis of biosynthetic gene clusters reveals vast potential of secondary metabolite production in Penicillium species

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7 January 2021

Minimum Information about a Biosynthetic Gene cluster.

1 reference

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7 January 2021

Natural products from filamentous fungi and production by heterologous expression

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7 January 2021

Bioinformatics tools for the identification of gene clusters that biosynthesize specialized metabolites

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7 January 2021

SMURF: Genomic mapping of fungal secondary metabolite clusters

1 reference

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7 January 2021

antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences

1 reference

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

7 January 2021

Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae

1 reference

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7 January 2021

Genome sequencing and analysis of Aspergillus oryzae

1 reference

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

7 January 2021

Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus

1 reference

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

7 January 2021

Dereplication of microbial metabolites through database search of mass spectra

1 reference

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

7 January 2021

Establishment of the Inducible Tet-On System for the Activation of the Silent Trichosetin Gene Cluster in Fusarium fujikuroi

1 reference

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

7 January 2021

Overexpression of the Global Regulator LaeA in Chaetomium globosum Leads to the Biosynthesis of Chaetoglobosin Z.

1 reference

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

7 January 2021

Transcriptomic Complexity of Aspergillus terreus Velvet Gene Family under the Influence of Butyrolactone I.

1 reference

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

7 January 2021

Symbiosis-inspired approaches to antibiotic discovery.

1 reference

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

7 January 2021

Technology development for natural product biosynthesis in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

7 January 2021

Recent advances in reconstructing microbial secondary metabolites biosynthesis in Aspergillus spp.

1 reference

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

7 January 2021

Discovery of cryptic polyketide metabolites from dermatophytes using heterologous expression in Aspergillus nidulans

1 reference

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

7 January 2021

The use of Fusarium secondary metabolite biosynthetic genes in chemotypic and phylogenetic studies

1 reference

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

7 January 2021

Evidence for horizontal transfer of a secondary metabolite gene cluster between fungi

1 reference

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

7 January 2021

Differential Retention of Gene Functions in a Secondary Metabolite Cluster

1 reference

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

7 January 2021

Secondary metabolite arsenal of an opportunistic pathogenic fungus.

1 reference

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

7 January 2021

Transcriptional regulation of chemical diversity in Aspergillus fumigatus by LaeA

1 reference

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

7 January 2021

Functional Analysis of the Fusarielin Biosynthetic Gene Cluster.

1 reference

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

7 January 2021

Repeated loss of an anciently horizontally transferred gene cluster in Botrytis.

1 reference

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

7 January 2021

Development of Genetic Dereplication Strains in Aspergillus nidulans Results in the Discovery of Aspercryptin.

1 reference

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

7 January 2021

Metabolic pathway gene clusters in filamentous fungi

1 reference

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

7 January 2021

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

1 reference

7 January 2021

Comprehensive annotation of secondary metabolite biosynthetic genes and gene clusters of Aspergillus nidulans, A. fumigatus, A. niger and A. oryzae

1 reference

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

7 January 2021

Phylogeny, identification and nomenclature of the genus Aspergillus

1 reference

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

7 January 2021

Identification and nomenclature of the genus Penicillium

1 reference

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

7 January 2021

A class-wide phylogenetic assessment of Dothideomycetes

1 reference

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

7 January 2021

Linking secondary metabolites to biosynthesis genes in the fungal endophyte Cyanodermella asteris: The anti-cancer bisanthraquinone skyrin

1 reference

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

7 January 2021

An Aspergillus nidulans bZIP response pathway hardwired for defensive secondary metabolism operates through aflR.

1 reference

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

7 January 2021

Overexpression of the Aspergillus nidulans histone 4 acetyltransferase EsaA increases activation of secondary metabolite production

1 reference

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7 January 2021

Sirtuin A regulates secondary metabolite production by Aspergillus nidulans.

1 reference

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

7 January 2021

Illuminating the diversity of aromatic polyketide synthases in Aspergillus nidulans

1 reference

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

7 January 2021

Regulation of fungal secondary metabolism

1 reference

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

7 January 2021

Revitalization of a Forward Genetic Screen Identifies Three New Regulators of Fungal Secondary Metabolism in the Genus Aspergillus

1 reference

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

7 January 2021

KdmA, a histone H3 demethylase with bipartite function, differentially regulates primary and secondary metabolism in Aspergillus nidulans

1 reference

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

7 January 2021

Regulation of secondary metabolism by chromatin structure and epigenetic codes.

1 reference

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

7 January 2021

antiSMASH 4.0-improvements in chemistry prediction and gene cluster boundary identification

1 reference

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

7 January 2021

CASSIS and SMIPS: promoter-based prediction of secondary metabolite gene clusters in eukaryotic genomes

1 reference

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

7 January 2021

FunGeneClusterS: Predicting fungal gene clusters from genome and transcriptome data.

1 reference

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

7 January 2021

SeMPI: a genome-based secondary metabolite prediction and identification web server

1 reference

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

7 January 2021

ClusterMine360: a database of microbial PKS/NRPS biosynthesis

1 reference

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

7 January 2021

IMG-ABC: A Knowledge Base To Fuel Discovery of Biosynthetic Gene Clusters and Novel Secondary Metabolites

1 reference

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

7 January 2021

Polyketide and nonribosomal peptide retro-biosynthesis and global gene cluster matching

1 reference

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

7 January 2021

NRPSpredictor2--a web server for predicting NRPS adenylation domain specificity

1 reference

https://api.crossref.org/works/10.1038%2FS41579-018-0121-1

7 January 2021

Cloning and heterologous expression of the penicillin biosynthetic gene cluster from penicillum chrysogenum

1 reference

12 December 2020

The cluster of penicillin biosynthetic genes. Identification and characterization of the pcbAB gene encoding the alpha-aminoadipyl-cysteinyl-valine synthetase and linkage to the pcbC and penDE genes

1 reference

12 December 2020

Effects of Light, Temperature, and p H Value on Aflatoxin Production In Vitro

1 reference

12 December 2020

Fungal lipopeptide mating pheromones: a model system for the study of protein prenylation

1 reference

12 December 2020

Physical and transcriptional map of an aflatoxin gene cluster in Aspergillus parasiticus and functional disruption of a gene involved early in the aflatoxin pathway

1 reference

12 December 2020

Pathogenic roles for fungal melanins

1 reference

12 December 2020

Functional analyses of Trichoderma reesei LAE1 reveal conserved and contrasting roles of this regulator

1 reference

12 December 2020

Pep2Path: automated mass spectrometry-guided genome mining of peptidic natural products

1 reference

12 December 2020

Biosynthesis of terpenoid natural products in fungi

1 reference

12 December 2020

Fungal secondary metabolite dynamics in fungus-grazer interactions: novel insights and unanswered questions

1 reference

12 December 2020

The importance of mass spectrometric dereplication in fungal secondary metabolite analysis

1 reference

12 December 2020

Genomes to natural products PRediction Informatics for Secondary Metabolomes (PRISM)

1 reference

12 December 2020

Biosynthesis of the mycotoxin tenuazonic acid by a fungal NRPS-PKS hybrid enzyme

1 reference

12 December 2020

A CRE1- regulated cluster is responsible for light dependent production of dihydrotrichotetronin in Trichoderma reesei

1 reference

12 December 2020

Drivers of genetic diversity in secondary metabolic gene clusters within a fungal species

1 reference

12 December 2020

CoIN: co-inducible nitrate expression system for secondary metabolites in Aspergillus nidulans.

1 reference

12 December 2020

An LaeA- and BrlA-Dependent Cellular Network Governs Tissue-Specific Secondary Metabolism in the Human Pathogen Aspergillus fumigatus.

1 reference

12 December 2020

HEx: A heterologous expression platform for the discovery of fungal natural products.

1 reference

12 December 2020

Fungal Isocyanide Synthases and Xanthocillin Biosynthesis in Aspergillus fumigatus.

1 reference

12 December 2020

10.1038/S41579-018-0121-1

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30531948%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

13 April 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30531948%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

1 reference