Surrogate end points in the design of immunotherapy trials: emerging lessons from type 1 diabetes (Q82633280)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20098462%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

review article

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title

Surrogate end points in the design of immunotherapy trials: emerging lessons from type 1 diabetes (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20098462%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

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2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20098462%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

author name string

Bart O Roep

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20098462%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

publication date

1 February 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20098462%20AND%20SRC:MED&resulttype=core&format=json

Nature Reviews Immunology

17 January 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20098462%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

volume

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20098462%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

issue

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20098462%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

page(s)

145-152

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20098462%20AND%20SRC:MED&resulttype=core&format=json

Immunotoxicology: role in the safety assessment of drugs

17 January 2020

cites work

1 reference

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TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs

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Rituximab, B-Lymphocyte Depletion, and Preservation of Beta-Cell Function

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Analysis of T-Cell Assays to Measure Autoimmune Responses in Subjects With Type 1 Diabetes

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Allergy test might have avoided drug-trial disaster

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Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs

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The habitual, diverse and surmountable obstacles to human immunology research

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"Cytokine storm" in the phase I trial of monoclonal antibody TGN1412: better understanding the causes to improve preclinical testing of immunotherapeutics

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Opinion: Satisfaction (not) guaranteed: re-evaluating the use of animal models of type 1 diabetes

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Mechanisms of Antibody Immunotherapy on Clonal Islet Reactive T Cells

31 March 2020

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Non-obese diabetic-recombination activating gene-1 (NOD-Rag1 null) interleukin (IL)-2 receptor common gamma chain (IL2r gamma null) null mice: a radioresistant model for human lymphohaematopoietic engraftment.

31 March 2020

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Serum concentrations of the interferon-gamma-inducible chemokine IP-10/CXCL10 are augmented in both newly diagnosed Type I diabetes mellitus patients and subjects at risk of developing the disease

31 March 2020

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Relation of circulating concentrations of chemokine receptor CCR5 ligands to C-peptide, proinsulin and HbA1c and disease progression in type 1 diabetes

31 March 2020

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Association of IL-1ra and adiponectin with C-peptide and remission in patients with type 1 diabetes

31 March 2020

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Innate immunity and heat shock response in islet transplantation

31 March 2020

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Distinct monocyte gene-expression profiles in autoimmune diabetes

31 March 2020

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Plasmacytoid dendritic cells are proportionally expanded at diagnosis of type 1 diabetes and enhance islet autoantigen presentation to T-cells through immune complex capture

31 March 2020

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Altered monocyte cyclo-oxygenase response in non-obese diabetic mice

31 March 2020

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Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health

31 March 2020

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Autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus

31 March 2020

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Murine antithymocyte globulin therapy alters disease progression in NOD mice by a time-dependent induction of immunoregulation

31 March 2020

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Increased resistance to CD4+CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetes

31 March 2020

1 reference

Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes.

31 March 2020

1 reference

The effector T cells of diabetic subjects are resistant to regulation via CD4+ FOXP3+ regulatory T cells

31 March 2020

1 reference

The A-chain of insulin is a hot-spot for CD4+ T cell epitopes in human type 1 diabetes.

31 March 2020

1 reference

Post-mortem analysis of islet pathology in type 1 diabetes illuminates the life and death of the beta cell

31 March 2020

1 reference

Gene expression profiles for the human pancreas and purified islets in type 1 diabetes: new findings at clinical onset and in long-standing diabetes.

31 March 2020

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31 March 2020

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31 March 2020

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Translational mini-review series on Th17 cells: are T helper 17 cells really pathogenic in autoimmunity?

31 March 2020

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Autoreactive CD8 T cells associated with beta cell destruction in type 1 diabetes

31 March 2020

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Analysis of islet inflammation in human type 1 diabetes.

31 March 2020

1 reference

Factors associated with early remission of type I diabetes in children treated with cyclosporine

31 March 2020

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Development of type 1 diabetes despite severe hereditary B-cell deficiency

31 March 2020

1 reference

Cellular islet autoimmunity associates with clinical outcome of islet cell transplantation

31 March 2020

1 reference

Differences in baseline lymphocyte counts and autoreactivity are associated with differences in outcome of islet cell transplantation in type 1 diabetic patients

31 March 2020

1 reference

Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives

31 March 2020

1 reference

Combined use of autoantibodies (IA-2 autoantibody, GAD autoantibody, insulin autoantibody, cytoplasmic islet cell antibodies) in type 1 diabetes: Combinatorial Islet Autoantibody Workshop

31 March 2020

1 reference

Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies

31 March 2020

1 reference

Human regulatory T cells: role in autoimmune disease and therapeutic opportunities

31 March 2020

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Re-establishing immune tolerance in type 1 diabetes via regulatory T cells.

31 March 2020

1 reference

Islet antigen specific IL-10+ immune responses but not CD4+CD25+FoxP3+ cells at diagnosis predict glycemic control in type 1 diabetes

31 March 2020

1 reference

Effects of insulin in relatives of patients with type 1 diabetes mellitus

31 March 2020

1 reference

Use of inhaled insulin in a basal/bolus insulin regimen in type 1 diabetic subjects: a 6-month, randomized, comparative trial

31 March 2020

1 reference

Pancreatic beta-cell function and immune responses to insulin after administration of intranasal insulin to humans at risk for type 1 diabetes

31 March 2020

1 reference

Association of T-cell reactivity with beta-cell function in recent onset type 1 diabetes patients

31 March 2020

1 reference

CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20098462

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial--Type 1.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20098462

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Islet transplantation in patients with autoimmune diabetes induces homeostatic cytokines that expand autoreactive memory T cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20098462

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRI2705

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20098462%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference