Involvement of caspase-6 and caspase-8 in neuronal apoptosis and the regenerative failure of injured retinal ganglion cells (Q84579923)

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8 February 2020

title

Involvement of caspase-6 and caspase-8 in neuronal apoptosis and the regenerative failure of injured retinal ganglion cells (English)

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8 February 2020

main subject

retinal ganglion cell

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1

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8 February 2020

Kinga Szydlowska

6

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8 February 2020

author name string

Philippe M D'Onofrio

2

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8 February 2020

Mark Magharious

3

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8 February 2020

Adam C Hollander

4

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8 February 2020

Nardos Tassew

5

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8 February 2020

Michael Tymianski

7

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8 February 2020

Paulo D Koeberle

8

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publication date

1 July 2011

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8 February 2020

published in

Journal of Neuroscience

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volume

31

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issue

29

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8 February 2020

page(s)

10494-10505

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describes a project that uses

8 February 2020

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6622648/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease.

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Long-term effect of inhibition of ced 3-like caspases on the survival of axotomized retinal ganglion cells in vivo

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Neuronal apoptosis induced by beta-amyloid is mediated by caspase-8.

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Evidence that Wallerian degeneration and localized axon degeneration induced by local neurotrophin deprivation do not involve caspases

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Lens injury stimulates axon regeneration in the mature rat optic nerve

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Live or let die - retinal ganglion cell death and survival during development and in the lesioned adult CNS.

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Regenerating the damaged central nervous system

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Caspase-9: involvement in secondary death of axotomized rat retinal ganglion cells in vivo

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Caspase-8 is an effector in apoptotic death of dopaminergic neurons in Parkinson's disease, but pathway inhibition results in neuronal necrosis.

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Caspase-9 activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease

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Activation of caspase-8 in the Alzheimer's disease brain.

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Phosphorylation of p85 beta PIX, a Rac/Cdc42-specific guanine nucleotide exchange factor, via the Ras/ERK/PAK2 pathway is required for basic fibroblast growth factor-induced neurite outgrowth

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12 December 2020

Caspase-6 is the direct activator of caspase-8 in the cytochrome c-induced apoptosis pathway: absolute requirement for removal of caspase-6 prodomain

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Truncated soluble Nogo receptor binds Nogo-66 and blocks inhibition of axon growth by myelin.

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P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp

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Independent roles of Rho-GTPases in growth cone and axonal behavior

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Increased beta-actin and tubulin polymerization in regrowing axons: relationship to the conditioning lesion effect

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Rho kinase inhibition enhances axonal regeneration in the injured CNS.

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The Rho/ROCK pathway mediates neurite growth-inhibitory activity associated with the chondroitin sulfate proteoglycans of the CNS glial scar

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Inactivation of myelin-associated glycoprotein enhances optic nerve regeneration.

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12 December 2020

Contribution of caspase-8 to apoptosis of axotomized rat retinal ganglion cells in vivo

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12 December 2020

Basic fibroblast growth factor stimulates activation of Rac1 through a p85 betaPIX phosphorylation-dependent pathway

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12 December 2020

Sprouting of axon-like processes from axotomized retinal ganglion cells induced by normal and preinjured intravitreal optic nerve grafts

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12 December 2020

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12 December 2020

Counteracting the Nogo receptor enhances optic nerve regeneration if retinal ganglion cells are in an active growth state.

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12 December 2020

Growth and guidance cues for regenerating axons: where have they gone?

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12 December 2020

Regulation of caspase activation in axotomized retinal ganglion cells

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12 December 2020

Synergistic effect of Nogo-neutralizing antibody IN-1 and ciliary neurotrophic factor on axonal regeneration in adult rodent visual systems

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12 December 2020

Active caspase-6 and caspase-6-cleaved tau in neuropil threads, neuritic plaques, and neurofibrillary tangles of Alzheimer's disease

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12 December 2020

Fas and activated caspase 8 in normal, Alzheimer and multiple infarct brains

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12 December 2020

Retinal ganglion cell death is delayed by activation of retinal intrinsic cell survival program

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12 December 2020

Unique and overlapping substrate specificities of caspase-8 and caspase-10.

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12 December 2020

Cdc42 participates in the regulation of ADF/cofilin and retinal growth cone filopodia by brain derived neurotrophic factor

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Coordinated expression of caspase 8, 3 and 7 mRNA in temporal cortex of Alzheimer disease: relationship to formic acid extractable abeta42 levels.

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Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin

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Myelin-associated inhibitors of neurite growth and regeneration in the CNS.

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Neuronal life-and-death signaling, apoptosis, and neurodegenerative disorders

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Inhibition of Rho kinase (ROCK) increases neurite outgrowth on chondroitin sulphate proteoglycan in vitro and axonal regeneration in the adult optic nerve in vivo

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12 December 2020

ROCK inhibition and CNTF interact on intrinsic signalling pathways and differentially regulate survival and regeneration in retinal ganglion cells

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12 December 2020

Transcriptional activation of caspase-6 and -7 genes by cisplatin-induced p53 and its functional significance in cisplatin nephrotoxicity

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12 December 2020

The upregulation of GLAST-1 is an indirect antiapoptotic mechanism of GDNF and neurturin in the adult CNS.

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12 December 2020

Axonal regeneration after optic nerve crush in Nogo-A/B/C knockout mice.

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12 December 2020

Targets of caspase-6 activity in human neurons and Alzheimer disease

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12 December 2020

Axon guidance: asymmetric signaling orients polarized outgrowth.

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12 December 2020

Phosphorylation of RhoGDI1 by p21-activated kinase 2 mediates basic fibroblast growth factor-stimulated neurite outgrowth in PC12 cells

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12 December 2020

The Jekyll and Hyde functions of caspases

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12 December 2020

The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration

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12 December 2020

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

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12 December 2020

Enhancement of activation of caspases by presenilin 1 gene mutations and its inhibition by secretase inhibitors

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12 December 2020

Ordering of caspases in cells undergoing apoptosis by the intrinsic pathway

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12 December 2020

Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6.

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12 December 2020

Axonal regeneration of optic nerve after crush in Nogo66 receptor knockout mice.

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12 December 2020

Involvement of Rac/Cdc42/PAK pathway in cytoskeletal rearrangements

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12 December 2020

ROCK inhibition promotes adult retinal ganglion cell neurite outgrowth only in the presence of growth promoting factors.

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12 December 2020

NgR RNA interference, combined with zymosan intravitreal injection, enhances optic nerve regeneration.

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12 December 2020

Receptors for myelin inhibitors: Structures and therapeutic opportunities

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12 December 2020

Calpain activates caspase-8 in neuron-like differentiated PC12 cells via the amyloid-beta-peptide and CD95 pathways.

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12 December 2020

The crystal structure of caspase-6, a selective effector of axonal degeneration

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12 December 2020

Axonal regeneration and neural network reconstruction in mammalian CNS.

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12 December 2020

Central nervous system regeneration inhibitors and their intracellular substrates

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12 December 2020

Genetically determined optic neuropathies

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12 December 2020

p75NTR-dependent, myelin-mediated axonal degeneration regulates neural connectivity in the adult brain

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12 December 2020

Mutant PIK3CA licenses TRAIL and CD95L to induce non-apoptotic caspase-8-mediated ROCK activation

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12 December 2020

Mechanisms of retinal ganglion cell injury and defense in glaucoma

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12 December 2020

Neuronal intrinsic barriers for axon regeneration in the adult CNS.

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12 December 2020

The repulsive guidance molecule, RGMa, promotes retinal ganglion cell survival in vitro and in vivo

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12 December 2020

Rac1 regulates neuronal polarization through the WAVE complex

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12 December 2020

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12 December 2020

Traumatic optic neuropathy: a review of the current literature

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12 December 2020

Growth of retinal ganglion cell axons following optic nerve crush in adult hamsters

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12 December 2020

Influences of peripheral nerve grafts on the survival and regrowth of axotomized retinal ganglion cells in adult rats

1 reference

12 December 2020

Qualitative and quantitative ultrastructural observations on retinal ganglion cell layer of rat after intraorbital optic nerve crush

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12 December 2020

Viability of retinal ganglion cells after optic nerve crush in adult rats

1 reference

12 December 2020

Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth

1 reference

12 December 2020

Retinal ganglion cell death in experimental glaucoma and after axotomy occurs by apoptosis

1 reference

12 December 2020

Injury induced expression of growth-associated protein-43 in adult mouse retinal ganglion cells in vitro

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12 December 2020

Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats.

1 reference

12 December 2020

Recovery of brightness discrimination in adult rats despite progressive loss of retrogradely labelled retinal ganglion cells after controlled optic nerve crush.

1 reference

12 December 2020

Peripheral nerve explants grafted into the vitreous body of the eye promote the regeneration of retinal ganglion cell axons severed in the optic nerve

1 reference

12 December 2020

Myelin-associated glycoprotein inhibits axonal regeneration from a variety of neurons via interaction with a sialoglycoprotein

1 reference

12 December 2020

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1 reference

12 December 2020

Myelin-associated glycoprotein inhibits neurite/axon growth and causes growth cone collapse

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12 December 2020

An induced proximity model for caspase-8 activation.

1 reference

12 December 2020

Inhibition of CPP32-like proteases rescues axotomized retinal ganglion cells from secondary cell death in vivo.

1 reference

12 December 2020

10.1523/JNEUROSCI.0148-11.2011

Identifiers

DOI

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8 February 2020

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8 February 2020

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