The pyrido[b]indole MDM2 inhibitor SP-141 exerts potent therapeutic effects in breast cancer models (Q85657017)

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20 February 2020

title

The pyrido[b]indole MDM2 inhibitor SP-141 exerts potent therapeutic effects in breast cancer models (English)

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20 February 2020

2

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20 February 2020

Subhasree Nag

5

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20 February 2020

10

John K Buolamwini

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20 February 2020

11

Ruiwen Zhang

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20 February 2020

9

Hui Wang

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20 February 2020

1

Wei Wang

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20 February 2020

author name string

Sukesh Voruganti

3

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20 February 2020

Kalkunte S Srivenugopal

4

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20 February 2020

Shivaputra Patil

6

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20 February 2020

Horrick Sharma

7

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20 February 2020

Ming-Hai Wang

8

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20 February 2020

publication date

1 October 2014

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20 February 2020

published in

Nature Communications

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volume

5

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page(s)

5086

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Molecular pathways: targeting Mdm2 and Mdm4 in cancer therapy

20 February 2020

cites work

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12 December 2020

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Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination

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An adenovirus mutant that replicates selectively in p53-deficient human tumor cells

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MDM2 interacts with the C-terminus of the catalytic subunit of DNA polymerase epsilon

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MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation.

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Triple-Negative Breast Cancer

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New insights into the mechanisms of organ-specific breast cancer metastasis

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Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

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Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

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Targeting the MDM2-p53 interaction for cancer therapy

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Regulation of p53 stability by Mdm2

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Targeting triple negative breast cancer: is p53 the answer?

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Protein-protein interactions regulate Ubl conjugation

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Regulation of XIAP translation and induction by MDM2 following irradiation

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Assessing TP53 status in human tumours to evaluate clinical outcome

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Alternative and aberrant messenger RNA splicing of the mdm2 oncogene in invasive breast cancer

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12 December 2020

Molecular mechanism of the interaction between MDM2 and p53.

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Mdm2 promotes the rapid degradation of p53

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Surfing the p53 network

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12 December 2020

MDM2 and human malignancies: expression, clinical pathology, prognostic markers, and implications for chemotherapy

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12 December 2020

Cancer statistics, 2014

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12 December 2020

Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis

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12 December 2020

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

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12 December 2020

Chest pain after emotional and physical upset

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Crossref

https://api.crossref.org/works/10.1038%2FNCOMMS6086

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NCOMMS6086

1 reference

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Dimensions Publication ID

20 February 2020

ADS bibcode

2014NatCo...5.5086W

0 references

0 references

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20 February 2020

PubMed publication ID

25271708

1 reference