Knockdown of PRAS40 inhibits insulin action via proteasome-mediated degradation of IRS1 in primary human skeletal muscle cells (Q86269744)

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25 February 2020

title

Knockdown of PRAS40 inhibits insulin action via proteasome-mediated degradation of IRS1 in primary human skeletal muscle cells (English)

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25 February 2020

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3

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25 February 2020

Margriet Ouwens

6

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25 February 2020

author name string

C Wiza

1

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25 February 2020

D Herzfeld de Wiza

2

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25 February 2020

S Lehr

4

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25 February 2020

H Al-Hasani

5

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25 February 2020

publication date

5 March 2013

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25 February 2020

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25 February 2020

volume

56

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25 February 2020

issue

5

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25 February 2020

page(s)

1118-1128

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https://scigraph.springernature.com/pub.10.1007/s00125-013-2861-9

25 February 2020

exact match

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Monocyte chemotactic protein-1 is a potential player in the negative cross-talk between adipose tissue and skeletal muscle

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Phosphorylation of PRAS40 on Thr246 by PKB/AKT facilitates efficient phosphorylation of Ser183 by mTORC1.

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Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation

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Impairment of insulin signaling in human skeletal muscle cells by co-culture with human adipocytes

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Chemerin is a novel adipocyte-derived factor inducing insulin resistance in primary human skeletal muscle cells.

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Insulin-induced insulin receptor substrate-1 degradation is mediated by the proteasome degradation pathway.

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Activation of the mammalian target of rapamycin pathway acutely inhibits insulin signaling to Akt and glucose transport in 3T3-L1 and human adipocytes.

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Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

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Dual ablation of Grb10 and Grb14 in mice reveals their combined role in regulation of insulin signaling and glucose homeostasis

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14-3-3 facilitates insulin-stimulated intracellular trafficking of insulin receptor substrate 1.

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Mice with a disruption of the imprinted Grb10 gene exhibit altered body composition, glucose homeostasis, and insulin signaling during postnatal life

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12 December 2020

SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2

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12 December 2020

PRAS40 acts as a nodal regulator of high glucose-induced TORC1 activation in glomerular mesangial cell hypertrophy

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12 December 2020

Insulin-mediated phosphorylation of the proline-rich Akt substrate PRAS40 is impaired in insulin target tissues of high-fat diet-fed rats

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12 December 2020

Sustained activation of the mammalian target of rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in mice

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A mutant insulin receptor induces formation of a Shc-growth factor receptor bound protein 2 (Grb2) complex and p21ras-GTP without detectable interaction of insulin receptor substrate 1 (IRS1) with Grb2. Evidence for IRS1-independent p21ras-GTP forma

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Proline-rich Akt substrate of 40kDa (PRAS40): a novel downstream target of PI3k/Akt signaling pathway.

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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

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PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding

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Ubiquitin ligase Cbl-b is a negative regulator for insulin-like growth factor 1 signaling during muscle atrophy caused by unloading.

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Down-regulation of the ubiquitin-proteasome proteolysis system by amino acids and insulin involves the adenosine monophosphate-activated protein kinase and mammalian target of rapamycin pathways in rat hepatocytes.

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Insulin resistance accelerates muscle protein degradation: Activation of the ubiquitin-proteasome pathway by defects in muscle cell signaling

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Regulation of insulin signalling by hyperinsulinaemia: role of IRS-1/2 serine phosphorylation and the mTOR/p70 S6K pathway

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Insulin stimulates the degradation of IRS-1 in 3T3-L1 adipocytes

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12 December 2020

Alcohol and PRAS40 knockdown decrease mTOR activity and protein synthesis via AMPK signaling and changes in mTORC1 interaction

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12 December 2020

Mechanisms for insulin resistance: common threads and missing links

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Loss of 50% of excess weight using a very low energy diet improves insulin-stimulated glucose disposal and skeletal muscle insulin signalling in obese insulin-treated type 2 diabetic patients

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PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

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12 December 2020

The SCF-Fbxo40 complex induces IRS1 ubiquitination in skeletal muscle, limiting IGF1 signaling

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12 December 2020

PRAS40 regulates protein synthesis and cell cycle in C2C12 myoblasts

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12 December 2020