HIV-2/SIV Vpx targets a novel functional domain of STING to selectively inhibit cGAS-STING-mediated NF-κB signalling (Q90975678)

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18 April 2020

title

HIV-2/SIV Vpx targets a novel functional domain of STING to selectively inhibit cGAS-STING-mediated NF-κB signalling (English)

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18 April 2020

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18 April 2020

author name string

Jiaming Su

1

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18 April 2020

Yajuan Rui

2

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18 April 2020

Meng Lou

3

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18 April 2020

Lu Yin

4

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18 April 2020

Hanchu Xiong

5

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18 April 2020

Zhenbang Zhou

6

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18 April 2020

Si Shen

7

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18 April 2020

Ting Chen

8

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18 April 2020

Zhengguo Zhang

9

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18 April 2020

Na Zhao

10

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18 April 2020

Wei Zhang

11

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18 April 2020

Yong Cai

12

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18 April 2020

Richard Markham

13

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18 April 2020

Shu Zheng

14

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18 April 2020

Rongzhen Xu

15

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18 April 2020

Wei Wei

16

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18 April 2020

publication date

28 October 2019

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18 April 2020

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18 April 2020

volume

4

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18 April 2020

issue

12

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18 April 2020

page(s)

2552-2564

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Isolation and characterization of a novel protein (X-ORF product) from SIV and HIV-2.

18 April 2020

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The Expression of Functional Vpx during Pathogenic SIVmac Infections of Rhesus Macaques Suppresses SAMHD1 in CD4+ Memory T Cells

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7 January 2021

Guanylate Binding Protein (GBP) 5 Is an Interferon-Inducible Inhibitor of HIV-1 Infectivity

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7 January 2021

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HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression

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7 January 2021

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7 January 2021

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7 January 2021

Species-Specific Deamidation of cGAS by Herpes Simplex Virus UL37 Protein Facilitates Viral Replication

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7 January 2021

Human Cytomegalovirus Tegument Protein UL82 Inhibits STING-Mediated Signaling to Evade Antiviral Immunity

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7 January 2021

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

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7 January 2021

Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling

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7 January 2021

Deregulation of STING Signaling in Colorectal Carcinoma Constrains DNA Damage Responses and Correlates With Tumorigenesis

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7 January 2021

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7 January 2021

HIV/simian immunodeficiency virus (SIV) accessory virulence factor Vpx loads the host cell restriction factor SAMHD1 onto the E3 ubiquitin ligase complex CRL4DCAF1.

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7 January 2021

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7 January 2021

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7 January 2021

The ability of primate lentiviruses to degrade the monocyte restriction factor SAMHD1 preceded the birth of the viral accessory protein Vpx.

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7 January 2021

Inhibition of Vpx-Mediated SAMHD1 and Vpr-Mediated Host Helicase Transcription Factor Degradation by Selective Disruption of Viral CRL4 (DCAF1) E3 Ubiquitin Ligase Assembly

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7 January 2021

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

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7 January 2021

Human immunodeficiency virus type 2 vpx protein augments viral infectivity

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7 January 2021

Evolution of the primate lentiviruses: evidence from vpx and vpr

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7 January 2021

HIV-2/SIV viral protein X counteracts HUSH repressor complex

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7 January 2021

Primate immunodeficiency virus proteins Vpx and Vpr counteract transcriptional repression of proviruses by the HUSH complex

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7 January 2021

Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells.

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7 January 2021

Vpx rescue of HIV-1 from the antiviral state in mature dendritic cells is independent of the intracellular deoxynucleotide concentration

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7 January 2021

SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4(+) T-cells

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7 January 2021

Viruses transfer the antiviral second messenger cGAMP between cells

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7 January 2021

Transmission of innate immune signaling by packaging of cGAMP in viral particles

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7 January 2021

Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.

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7 January 2021

SIV vpx is essential for macrophage infection but not for development of AIDS.

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7 January 2021

Vpr Enhances Tumor Necrosis Factor Production by HIV-1-Infected T Cells

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7 January 2021

Sensing of HIV-1 Infection in Tzm-bl Cells with Reconstituted Expression of STING.

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7 January 2021

Premature activation of the SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensing

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7 January 2021

Primate lentiviruses use at least three alternative strategies to suppress NF-κB-mediated immune activation

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7 January 2021

Disruption of MDA5-Mediated Innate Immune Responses by the 3C Proteins of Coxsackievirus A16, Coxsackievirus A6, and Enterovirus D68.

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7 January 2021

10.1038/S41564-019-0585-4

Identifiers

DOI

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18 April 2020

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