BCL2-associated X protein (Q14905404)

Apoptosis regulator BAX

1 reference

Apoptosis regulator, Bcl-2, BH3 motif, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Apoptosis regulator, Bcl-2, BH1 motif, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Apoptosis regulator, Bcl-2, BH2 motif, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

protein homodimerization activity

5 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Bax and Bcl-2 interaction in a transgenic mouse model of familial amyotrophic lateral sclerosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

11 references

8 April 2019

BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bcl-2 family interaction with the mitochondrial morphogenesis machinery

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

BID: a novel BH3 domain-only death agonist

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Upregulation of Bcl2 inhibits apoptosis-driven BAX insertion but favors BAX relocalization in mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

protein heterodimerization activity

IPI

7 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Bcl-XL and Bcl-2 repress a common pathway of cell death

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Bax can antagonize Bcl-XL during etoposide and cisplatin-induced cell death independently of its heterodimerization with Bcl-XL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

BID: a novel BH3 domain-only death agonist

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

1 reference

27 February 2018

hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria

IPI

Hsp70 protein binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

identical protein binding

3 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Solution Structure of Apoptotic BAX Oligomer: Oligomerization Likely Precedes Membrane Insertion.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

heat shock protein binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

protein homodimerization activity

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax and Bcl-2 interaction in a transgenic mouse model of familial amyotrophic lateral sclerosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

protein-containing complex binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

protein heterodimerization activity

8 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

BID: a novel BH3 domain-only death agonist

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bcl-XL and Bcl-2 repress a common pathway of cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax can antagonize Bcl-XL during etoposide and cisplatin-induced cell death independently of its heterodimerization with Bcl-XL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

12 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

The course of etoposide-induced apoptosis from damage to DNA and p53 activation to mitochondrial release of cytochrome c

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Spatial and temporal changes in Bax subcellular localization during anoikis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Activation of pro-death Bcl-2 family proteins and mitochondria apoptosis pathway in tumor necrosis factor-alpha-induced liver injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

Bcl-2 family protein complex

15 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

The Bax N terminus is required for negative regulation by the mitogen-activated protein kinase kinase and Akt signaling pathways in T cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

A mitochondrial protein compendium elucidates complex I disease biology

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

The course of etoposide-induced apoptosis from damage to DNA and p53 activation to mitochondrial release of cytochrome c

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Caspases 3 and 7: key mediators of mitochondrial events of apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Activation of pro-death Bcl-2 family proteins and mitochondria apoptosis pathway in tumor necrosis factor-alpha-induced liver injury

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Bcl-2 family interaction with the mitochondrial morphogenesis machinery

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

mitochondrial permeability transition pore complex

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

intracellular anatomical structure

endoplasmic reticulum

2 references

27 February 2018

Bcl-2 lies downstream of parathyroid hormone-related peptide in a signaling pathway that regulates chondrocyte maturation during skeletal development

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Pro- and anti-apoptotic members of the Bcl-2 family in skeletal muscle: a distinct role for Bcl-2 in later stages of myogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

endoplasmic reticulum membrane

mitochondrial outer membrane

4 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Cidea-deficient mice have lean phenotype and are resistant to obesity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Spatial and temporal changes in Bax subcellular localization during anoikis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice

mitochondrial membranes

3 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Bax-induced cytochrome c release from mitochondria depends on alpha-helices-5 and -6

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Activation of pro-death Bcl-2 family proteins and mitochondria apoptosis pathway in tumor necrosis factor-alpha-induced liver injury

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

10 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

The Bax N terminus is required for negative regulation by the mitogen-activated protein kinase kinase and Akt signaling pathways in T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Caspases 3 and 7: key mediators of mitochondrial events of apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Apoptosis in the pattern formation of the ventricular wall during mouse heart organogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

p53 and Bax: putative death factors in taste cell turnover

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Gustatory innervation and bax-dependent caspase-2: participants in the life and death pathways of mouse taste receptor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

15 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

The course of etoposide-induced apoptosis from damage to DNA and p53 activation to mitochondrial release of cytochrome c

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

The Bax N terminus is required for negative regulation by the mitogen-activated protein kinase kinase and Akt signaling pathways in T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Activation of pro-death Bcl-2 family proteins and mitochondria apoptosis pathway in tumor necrosis factor-alpha-induced liver injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bcl-2 family interaction with the mitochondrial morphogenesis machinery

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Caspases 3 and 7: key mediators of mitochondrial events of apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

A mitochondrial protein compendium elucidates complex I disease biology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

mitochondrial outer membrane

HDA

7 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Spatial and temporal changes in Bax subcellular localization during anoikis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Cidea-deficient mice have lean phenotype and are resistant to obesity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

mitochondrial membranes

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax-induced cytochrome c release from mitochondria depends on alpha-helices-5 and -6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Activation of pro-death Bcl-2 family proteins and mitochondria apoptosis pathway in tumor necrosis factor-alpha-induced liver injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

perinuclear region of cytoplasm

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

negative regulation of neuron apoptotic process

biological process

1 reference

8 April 2019

Bax promotes neuronal survival and antagonises the survival effects of neurotrophic factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis

germ cell development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

positive regulation of calcium ion transport into cytosol

1 reference

8 April 2019

Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

glycosphingolipid metabolic process

1 reference

8 April 2019

Male germ cells require polyenoic sphingolipids with complex glycosylation for completion of meiosis: a link to ceramide synthase-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

Susceptibility to metanephric apoptosis in bradykinin B2 receptor null mice via the p53-Bax pathway

B cell apoptotic process

response to salt stress

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

Sertoli cell proliferation

1 reference

8 April 2019

BCLW mediates survival of postmitotic Sertoli cells by regulating BAX activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

thymocyte apoptotic process

1 reference

8 April 2019

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

post-embryonic development

1 reference

8 April 2019

Bcl-2 and Bax function independently to regulate cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

negative regulation of protein binding

regulation of mitochondrial membrane permeability involved in programmed necrotic cell death

1 reference

8 April 2019

Bax regulates primary necrosis through mitochondrial dynamics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

odontogenesis of dentin-containing tooth

1 reference

8 April 2019

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

1 reference

27 February 2018

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

Persistent fetal ocular vasculature in mice deficient in bax and bak

blood vessel remodeling

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

positive regulation of neuron apoptotic process

20 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bok Is Not Pro-Apoptotic But Suppresses Poly ADP-Ribose Polymerase-Dependent Cell Death Pathways and Protects against Excitotoxic and Seizure-Induced Neuronal Injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

BAX is required for neuronal death after trophic factor deprivation and during development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Development of pontine noradrenergic A5 neurons requires brain-derived neurotrophic factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Effects of Bax gene deletion on muscle and motoneuron degeneration in a sexually dimorphic neuromuscular system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Widespread elimination of naturally occurring neuronal death in Bax-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Differences in bcl-2- and bax-independent function in regulating apoptosis in sensory neuron populations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Neuromuscular development in the absence of programmed cell death: phenotypic alteration of motoneurons and muscle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Suppression of developmental retinal cell death but not of photoreceptor degeneration in Bax-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bcl-X(L)-caspase-9 interactions in the developing nervous system: evidence for multiple death pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Programmed cell death of adult-generated hippocampal neurons is mediated by the proapoptotic gene Bax

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Ethanol-induced neuronal apoptosis in vivo requires BAX in the developing mouse brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax limits adult neural stem cell persistence through caspase and IP3 receptor activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Reversible physiological alterations in sympathetic neurons deprived of NGF but protected from apoptosis by caspase inhibition or Bax deletion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax inactivation in lurcher mutants rescues cerebellar granule cells but not purkinje cells or inferior olivary neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Subtle shifts in the ratio between pro- and antiapoptotic molecules after activation of corticosteroid receptors decide neuronal fate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax deficiency prevents the increased cell death of immature neurons in bcl-x-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

apoptotic process involved in blood vessel morphogenesis

1 reference

8 April 2019

Persistent fetal ocular vasculature in mice deficient in bax and bak

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax and Bak independently promote cytochrome C release from mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax directly induces release of cytochrome c from isolated mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

3 references

8 April 2019

Bax-deficient mice with lymphoid hyperplasia and male germ cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax-dependent spermatogonia apoptosis is required for testicular development and spermatogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

intrinsic apoptotic signaling pathway in response to DNA damage

3 references

27 February 2018

Integral role of Noxa in p53-mediated apoptotic response

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

apoptotic signaling pathway

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Enhanced Oligodendrocyte Survival after Spinal Cord Injury in Bax-Deficient Mice and Mice with Delayed Wallerian Degeneration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Spatial and temporal changes in Bax subcellular localization during anoikis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

mitochondrion morphogenesis

1 reference

8 April 2019

Bcl-2 family interaction with the mitochondrial morphogenesis machinery

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

activation of cysteine-type endopeptidase activity involved in apoptotic process

7 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Olfactory neurons in bax knockout mice are protected from bulbectomy-induced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Ethanol-induced neuronal apoptosis in vivo requires BAX in the developing mouse brain

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Proapoptotic BAX and BAK control multiple initiator caspases

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Neuronal apoptosis inhibitory protein is expressed in developing kidney and is regulated by PAX2

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

negative regulation of cell population proliferation

1 reference

8 April 2019

Differences in bcl-2- and bax-independent function in regulating apoptosis in sensory neuron populations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax directly induces release of cytochrome c from isolated mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

regulation of apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

cellular response to organic substance

1 reference

8 April 2019

Apoptosis and related proteins in placenta of intrauterine fetal death in prostaglandin f receptor-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

B cell homeostatic proliferation

1 reference

8 April 2019

Bax-deficient mice with lymphoid hyperplasia and male germ cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

1 reference

8 April 2019

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

release of matrix enzymes from mitochondria

1 reference

8 April 2019

Bcl-2 and Bax function independently to regulate cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

1 reference

8 April 2019

Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

negative regulation of apoptotic signaling pathway

1 reference

8 April 2019

Nanos3 maintains the germ cell lineage in the mouse by suppressing both Bax-dependent and -independent apoptotic pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

myeloid cell homeostasis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

regulation of neuron apoptotic process

1 reference

8 April 2019

A differential developmental pattern of spinal interneuron apoptosis during synaptogenesis: insights from genetic analyses of the protocadherin-gamma gene cluster

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

regulation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

8 April 2019

Enhanced Oligodendrocyte Survival after Spinal Cord Injury in Bax-Deficient Mice and Mice with Delayed Wallerian Degeneration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

1 reference

8 April 2019

Enhanced Oligodendrocyte Survival after Spinal Cord Injury in Bax-Deficient Mice and Mice with Delayed Wallerian Degeneration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

intrinsic apoptotic signaling pathway by p53 class mediator

1 reference

8 April 2019

Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

Deletion of Bax eliminates sex differences in the mouse forebrain

hypothalamus development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

protein homooligomerization

response to gamma radiation

1 reference

8 April 2019

Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by p53, bak, bax, and bcl-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

negative regulation of fibroblast proliferation

1 reference

8 April 2019

Integral role of Noxa in p53-mediated apoptotic response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

positive regulation of intrinsic apoptotic signaling pathway

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Ethanol-induced neuronal apoptosis in vivo requires BAX in the developing mouse brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

response to toxic substance

B cell negative selection

1 reference

8 April 2019

Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

5 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Role of Bax and Bak in mitochondrial morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons

neuron apoptotic process

9 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Neuromuscular development after the prevention of naturally occurring neuronal death by Bax deletion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Gamma protocadherins are required for synaptic development in the spinal cord

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Epistatic and independent functions of caspase-3 and Bcl-X(L) in developmental programmed cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Changes in cortical and striatal neurons predict behavioral and electrophysiological abnormalities in a transgenic murine model of Huntington's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Differences in bcl-2- and bax-independent function in regulating apoptosis in sensory neuron populations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

NMDA receptors promote survival in somatosensory relay nuclei by inhibiting Bax-dependent developmental cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

positive regulation of B cell apoptotic process

1 reference

8 April 2019

Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated lymphomagenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

cellular response to UV

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

1 reference

8 April 2019

Deletion of Bax eliminates sex differences in the mouse forebrain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

1 reference

8 April 2019

Programmed cell death of adult-generated hippocampal neurons is mediated by the proapoptotic gene Bax

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

positive regulation of release of sequestered calcium ion into cytosol

1 reference

8 April 2019

Bax limits adult neural stem cell persistence through caspase and IP3 receptor activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

positive regulation of apoptotic process involved in mammary gland involution

1 reference

8 April 2019

Gain of Bcl-2 is more potent than bax loss in regulating mammary epithelial cell survival in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

nervous system development

1 reference

8 April 2019

Brn3a regulation of TrkA/NGF receptor expression in developing sensory neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

spermatid differentiation

1 reference

8 April 2019

Concomitant loss of proapoptotic BH3-only Bcl-2 antagonists Bik and Bim arrests spermatogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

development of secondary sexual characteristics

1 reference

8 April 2019

Effects of Bax gene deletion on muscle and motoneuron degeneration in a sexually dimorphic neuromuscular system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

positive regulation of developmental pigmentation

1 reference

8 April 2019

Bcl-2 and Bax function independently to regulate cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

retina development in camera-type eye

1 reference

8 April 2019

Suppression of developmental retinal cell death but not of photoreceptor degeneration in Bax-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage

response to axon injury

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

positive regulation of mitochondrial membrane permeability involved in apoptotic process

1 reference

8 April 2019

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

1 reference

8 April 2019

Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

ectopic germ cell programmed cell death

3 references

8 April 2019

The pro-apoptotic gene Bax is required for the death of ectopic primordial germ cells during their migration in the mouse embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

The pro-apoptotic gene Bax is required for the death of ectopic primordial germ cells during their migration in the mouse embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Steel factor controls midline cell death of primordial germ cells and is essential for their normal proliferation and migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

positive regulation of release of cytochrome c from mitochondria

negative regulation of endoplasmic reticulum calcium ion concentration

1 reference

8 April 2019

Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

regulation of protein homodimerization activity

protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

1 reference

8 April 2019

Integral role of Noxa in p53-mediated apoptotic response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

apoptotic process involved in embryonic digit morphogenesis

1 reference

8 April 2019

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

leukocyte homeostasis

mitochondrial fragmentation involved in apoptotic process

positive regulation of endoplasmic reticulum unfolded protein response

establishment or maintenance of transmembrane electrochemical gradient

homeostasis of number of cells

1 reference

8 April 2019

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

post-embryonic camera-type eye morphogenesis

1 reference

8 April 2019

Persistent fetal ocular vasculature in mice deficient in bax and bak

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

regulation of mammary gland epithelial cell proliferation

1 reference

8 April 2019

Gain of Bcl-2 is more potent than bax loss in regulating mammary epithelial cell survival in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

retinal cell programmed cell death

1 reference

8 April 2019

Major role of BAX in apoptosis during retinal development and in establishment of a functional postnatal retina

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease

regulation of cell cycle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

regulation of mitochondrial membrane potential

1 reference

8 April 2019

Bax-induced cytochrome c release from mitochondria depends on alpha-helices-5 and -6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Proapoptotic BAX and BAK control multiple initiator caspases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

apoptotic mitochondrial changes

regulation of nitrogen utilization

1 reference

8 April 2019

Bcl-2 and Bax function independently to regulate cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

negative regulation of peptidyl-serine phosphorylation

1 reference

8 April 2019

Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

positive regulation of protein oligomerization

positive regulation of apoptotic process

16 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Decreased glucose transporter expression triggers BAX-dependent apoptosis in the murine blastocyst

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Prostaglandin E2 reduces radiation-induced epithelial apoptosis through a mechanism involving AKT activation and bax translocation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

The role of Bax in glutamate-induced nerve cell death

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Bax-dependent spermatogonia apoptosis is required for testicular development and spermatogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Prolongation of ovarian lifespan into advanced chronological age by Bax-deficiency

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by p53, bak, bax, and bcl-2

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Bcl-2 and Bax function independently to regulate cell death

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

TRPM-2 expression and tunel staining in neurodegenerative diseases: studies in wobbler and rd mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Bax can antagonize Bcl-XL during etoposide and cisplatin-induced cell death independently of its heterodimerization with Bcl-XL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Steel factor controls midline cell death of primordial germ cells and is essential for their normal proliferation and migration

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Susceptibility to metanephric apoptosis in bradykinin B2 receptor null mice via the p53-Bax pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Mammalian prion protein suppresses Bax-induced cell death in yeast

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

extrinsic apoptotic signaling pathway in absence of ligand

extrinsic apoptotic signaling pathway via death domain receptors

1 reference

8 April 2019

Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

release of cytochrome c from mitochondria

8 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

A stapled BID BH3 helix directly binds and activates BAX

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Bax directly induces release of cytochrome c from isolated mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Bax-induced cytochrome c release from mitochondria depends on alpha-helices-5 and -6

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

27 February 2018

Spatial and temporal changes in Bax subcellular localization during anoikis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07813&geneProductId=UniProtKB:Q07813

cerebral cortex development

1 reference

8 April 2019

Deletion of Bax eliminates sex differences in the mouse forebrain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

release of cytochrome c from mitochondria

9 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

A stapled BID BH3 helix directly binds and activates BAX

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax-induced cytochrome c release from mitochondria depends on alpha-helices-5 and -6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Spatial and temporal changes in Bax subcellular localization during anoikis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax directly induces release of cytochrome c from isolated mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

activation of cysteine-type endopeptidase activity involved in apoptotic process

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Olfactory neurons in bax knockout mice are protected from bulbectomy-induced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Ethanol-induced neuronal apoptosis in vivo requires BAX in the developing mouse brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Proapoptotic BAX and BAK control multiple initiator caspases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

inner mitochondrial membrane organization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

outer mitochondrial membrane organization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Role of Bax and Bak in mitochondrial morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

intrinsic apoptotic signaling pathway in response to DNA damage

4 references

8 April 2019

Integral role of Noxa in p53-mediated apoptotic response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

positive regulation of apoptotic process

17 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

The role of Bax in glutamate-induced nerve cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax-dependent spermatogonia apoptosis is required for testicular development and spermatogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by p53, bak, bax, and bcl-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Prostaglandin E2 reduces radiation-induced epithelial apoptosis through a mechanism involving AKT activation and bax translocation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Decreased glucose transporter expression triggers BAX-dependent apoptosis in the murine blastocyst

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Prolongation of ovarian lifespan into advanced chronological age by Bax-deficiency

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bcl-2 and Bax function independently to regulate cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Susceptibility to metanephric apoptosis in bradykinin B2 receptor null mice via the p53-Bax pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Bax can antagonize Bcl-XL during etoposide and cisplatin-induced cell death independently of its heterodimerization with Bcl-XL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Steel factor controls midline cell death of primordial germ cells and is essential for their normal proliferation and migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

TRPM-2 expression and tunel staining in neurodegenerative diseases: studies in wobbler and rd mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Mammalian prion protein suppresses Bax-induced cell death in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

extrinsic apoptotic signaling pathway in absence of ligand

3 references

8 April 2019

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Growth factor regulation of autophagy and cell survival in the absence of apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

negative regulation of mitochondrial membrane potential

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07813

Apoptosis regulator, Bcl-2, BH2 motif, conserved site

ISS

has part(s)

1 reference

Apoptosis regulator, Bcl-2, BH1 motif, conserved site

1 reference

Apoptosis regulator, Bcl-2, BH3 motif, conserved site

1 reference