Heat shock protein 90 alpha family class A member 1 (Q21108142)

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mammalian protein found in Homo sapiens
  • HSP90AA1
  • HSP 86
  • heat shock 90kD protein 1, alpha-like 4
  • heat shock 90kDa protein 1, alpha
  • heat shock protein HSP 90-alpha
  • heat shock protein 90kDa alpha family class A member 1
  • heat shock protein 90kDa alpha (cytosolic), class A member 1
  • heat shock 86 kDa
  • HSP86
  • heat shock 90kD protein, alpha-like 4
  • heat shock 90kD protein 1, alpha
  • LPS-associated protein 2
  • lipopolysaccharide-associated protein 2
  • epididymis secretory sperm binding protein Li 65p
  • LAP-2
  • renal carcinoma antigen NY-REN-38
  • epididymis luminal secretory protein 52
edit
Language Label Description Also known as
English
Heat shock protein 90 alpha family class A member 1
mammalian protein found in Homo sapiens
  • HSP90AA1
  • HSP 86
  • heat shock 90kD protein 1, alpha-like 4
  • heat shock 90kDa protein 1, alpha
  • heat shock protein HSP 90-alpha
  • heat shock protein 90kDa alpha family class A member 1
  • heat shock protein 90kDa alpha (cytosolic), class A member 1
  • heat shock 86 kDa
  • HSP86
  • heat shock 90kD protein, alpha-like 4
  • heat shock 90kD protein 1, alpha
  • LPS-associated protein 2
  • lipopolysaccharide-associated protein 2
  • epididymis secretory sperm binding protein Li 65p
  • LAP-2
  • renal carcinoma antigen NY-REN-38
  • epididymis luminal secretory protein 52

Statements

molecular function
protein binding
determination method
IPI
55 references
retrieved
17 October 2017
stated in
Small glutamine-rich tetratricopeptide repeat-containing protein is composed of three structural units with distinct functions
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
Distinct roles of molecular chaperones HSP90α and HSP90β in the biogenesis of KCNQ4 channels
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
Hsp90 stabilizes Cdc25A and counteracts heat shock-mediated Cdc25A degradation and cell-cycle attenuation in pancreatic carcinoma cells
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
Heat shock protein 90 as an endogenous protein enhancer of inducible nitric-oxide synthase
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
Middle domain of human Hsp90 isoforms differentially binds Aha1 in human cells and alters Hsp90 activity in yeast
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
C-terminal domain of SMYD3 serves as a unique HSP90-regulated motif in oncogenesis
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
An interaction network predicted from public data as a discovery tool: application to the Hsp90 molecular chaperone machine
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
Stat1 mediates an auto-regulation of hsp90beta gene in heat shock response
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
NudC-like protein 2 regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
A comprehensive resource of interacting protein regions for refining human transcription factor networks
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
Secreted heat shock protein 90alpha induces colorectal cancer cell invasion through CD91/LRP-1 and NF-kappaB-mediated integrin alphaV expression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
HiQuant: Rapid Postquantification Analysis of Large-Scale MS-Generated Proteomics Data.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
Hepatitis C virus RNA replication is regulated by FKBP8 and Hsp90
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
A human protein-protein interaction network: a resource for annotating the proteome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
Glucocorticoid receptor function regulated by coordinated action of the Hsp90 and Hsp70 chaperone cycles
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
S100 proteins regulate the interaction of Hsp90 with Cyclophilin 40 and FKBP52 through their tetratricopeptide repeats
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
Apigenin inhibits proliferation and induces apoptosis in human multiple myeloma cells through targeting the trinity of CK2, Cdc37 and Hsp90
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
HSP90 regulates cell survival via inositol hexakisphosphate kinase-2.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
S100A1 is a novel molecular chaperone and a member of the Hsp70/Hsp90 multichaperone complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
Label-free quantitative proteomics and SAINT analysis enable interactome mapping for the human Ser/Thr protein phosphatase 5
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
A human MAP kinase interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
Structural Basis for Phosphorylation-Dependent Recruitment of Tel2 to Hsp90 by Pih1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
Identification of VCP/p97, carboxyl terminus of Hsp70-interacting protein (CHIP), and amphiphysin II interaction partners using membrane-based human proteome arrays
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
HSP90 is required for TAK1 stability but not for its activation in the pro-inflammatory signaling pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
A truncated form of p23 down-regulates telomerase activity via disruption of Hsp90 function
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
The pathogenic E. coli type III effector EspZ interacts with host CD98 and facilitates host cell prosurvival signalling
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
identical protein binding
determination method
IPI
5 references
retrieved
17 October 2017
stated in
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
Label-free quantitative proteomics and SAINT analysis enable interactome mapping for the human Ser/Thr protein phosphatase 5
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
A human protein-protein interaction network: a resource for annotating the proteome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
The client protein p53 adopts a molten globule-like state in the presence of Hsp90.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
17 October 2017
stated in
The carboxy-terminal region of mammalian HSP90 is required for its dimerization and function in vivo
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IPI
protein binding
determination method
IBA
IPI
57 references
retrieved
1 January 2018
stated in
Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
An interaction network predicted from public data as a discovery tool: application to the Hsp90 molecular chaperone machine
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
Middle domain of human Hsp90 isoforms differentially binds Aha1 in human cells and alters Hsp90 activity in yeast
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
Heat shock protein 90 as an endogenous protein enhancer of inducible nitric-oxide synthase
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
Hsp90 stabilizes Cdc25A and counteracts heat shock-mediated Cdc25A degradation and cell-cycle attenuation in pancreatic carcinoma cells
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
Stat1 mediates an auto-regulation of hsp90beta gene in heat shock response
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
Distinct roles of molecular chaperones HSP90α and HSP90β in the biogenesis of KCNQ4 channels
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
C-terminal domain of SMYD3 serves as a unique HSP90-regulated motif in oncogenesis
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
Small glutamine-rich tetratricopeptide repeat-containing protein is composed of three structural units with distinct functions
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
Hepatitis C virus RNA replication is regulated by FKBP8 and Hsp90
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
A human MAP kinase interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
A human protein-protein interaction network: a resource for annotating the proteome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
Glucocorticoid receptor function regulated by coordinated action of the Hsp90 and Hsp70 chaperone cycles
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
S100 proteins regulate the interaction of Hsp90 with Cyclophilin 40 and FKBP52 through their tetratricopeptide repeats
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
Apigenin inhibits proliferation and induces apoptosis in human multiple myeloma cells through targeting the trinity of CK2, Cdc37 and Hsp90
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
HSP90 regulates cell survival via inositol hexakisphosphate kinase-2.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
NudC-like protein 2 regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
S100A1 is a novel molecular chaperone and a member of the Hsp70/Hsp90 multichaperone complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
HiQuant: Rapid Postquantification Analysis of Large-Scale MS-Generated Proteomics Data.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
Identification of VCP/p97, carboxyl terminus of Hsp70-interacting protein (CHIP), and amphiphysin II interaction partners using membrane-based human proteome arrays
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
HSP90 is required for TAK1 stability but not for its activation in the pro-inflammatory signaling pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
Secreted heat shock protein 90alpha induces colorectal cancer cell invasion through CD91/LRP-1 and NF-kappaB-mediated integrin alphaV expression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
A comprehensive resource of interacting protein regions for refining human transcription factor networks
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
Structural Basis for Phosphorylation-Dependent Recruitment of Tel2 to Hsp90 by Pih1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
Label-free quantitative proteomics and SAINT analysis enable interactome mapping for the human Ser/Thr protein phosphatase 5
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
A truncated form of p23 down-regulates telomerase activity via disruption of Hsp90 function
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
The pathogenic E. coli type III effector EspZ interacts with host CD98 and facilitates host cell prosurvival signalling
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IBA
identical protein binding
determination method
IDA
IPI
6 references
retrieved
1 January 2018
stated in
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
A human protein-protein interaction network: a resource for annotating the proteome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
Label-free quantitative proteomics and SAINT analysis enable interactome mapping for the human Ser/Thr protein phosphatase 5
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
The carboxy-terminal region of mammalian HSP90 is required for its dimerization and function in vivo
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
The client protein p53 adopts a molten globule-like state in the presence of Hsp90.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IPI
retrieved
1 January 2018
stated in
Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
IDA
cell component
extracellular exosome
determination method
IDA
6 references
retrieved
17 October 2017
stated in
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IDA
retrieved
17 October 2017
stated in
Intestinal epithelial cells secrete exosome-like vesicles
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IDA
retrieved
17 October 2017
stated in
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IDA
retrieved
17 October 2017
stated in
Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IDA
retrieved
17 October 2017
stated in
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IDA
retrieved
17 October 2017
stated in
Proteomic analysis of podocyte exosome-enriched fraction from normal human urine
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P07900&geneProductId=UniProtKB:P07900
determination method
IDA
extracellular exosome
determination method
HDA
5 references
retrieved
1 January 2018
stated in
Intestinal epithelial cells secrete exosome-like vesicles
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
HDA
retrieved
1 January 2018
stated in
Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
HDA
retrieved
1 January 2018
stated in
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
HDA
retrieved
1 January 2018
stated in
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
HDA
retrieved
1 January 2018
stated in
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine
GOA
curator
UniProt
UniProt protein ID
P07900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07900
determination method
HDA
biological process

Identifiers

PDB structure ID
 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q21108142&oldid=2022932292"