Annexin A2 is a C-terminal PCSK9-binding protein that regulates endogenous low density lipoprotein receptor levels (Q24313575)

Gene Ontology release 2020-05-02

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Gene Ontology release 2020-05-02

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Gene Ontology release 2020-05-02

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GOA release 2020-03-11

Proprotein convertase subtilisin/kexin type 9

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Journal of Biological Chemistry

GOA release 2020-03-11

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Nabil G Seidah

3

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author name string

Gaétan Mayer

series ordinal

1

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Steve Poirier

series ordinal

2

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language of work or name

English

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publication date

14 November 2008

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published in

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volume

283

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issue

46

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page(s)

31791-801

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The proprotein convertases are potential targets in the treatment of dyslipidemia

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Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9

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Effect of mutations in the PCSK9 gene on the cell surface LDL receptors

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Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment

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Catalytic activity is not required for secreted PCSK9 to reduce low density lipoprotein receptors in HepG2 cells

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The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2

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Extracellular annexin II.

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Functional characterization of Narc 1, a novel proteinase related to proteinase K

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Annexins--unique membrane binding proteins with diverse functions

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Caveolae: uniform structures with multiple functions in signaling, cell growth, and cancer

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An annexin 2 phosphorylation switch mediates p11-dependent translocation of annexin 2 to the cell surface

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Cell surface annexin II is a high affinity receptor for the alternatively spliced segment of tenascin-C

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Annexin II regulates fibrin homeostasis and neoangiogenesis in vivo

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Plasma PCSK9 preferentially reduces liver LDL receptors in mice

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Expression of annexins on the surfaces of non-metastatic and metastatic human and rodent tumor cells

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inferred from DOI database lookup

7 January 2021

based on heuristic

Translocation of cytosolic annexin 2 to a Triton-insoluble membrane subdomain upon nicotine stimulation of chromaffin cultured cells

1 reference

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1074/JBC.M805971200

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

18799458

1 reference

Consolidated OpenCitations Corpus – April 2017