The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2 (Q24301411)

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English	The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2	scientific article

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The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2 (English)

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Proprotein convertase subtilisin/kexin type 9

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GOA release 2020-03-11

very-low-density lipoprotein particle receptor binding

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GOA release 2020-03-11

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based on heuristic

inferred from title

4

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object named as

Annik Prat

9

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object named as

Nabil G Seidah

10

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author name string

Steve Poirier

1

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Gaetan Mayer

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Suzanne Benjannet

3

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Jadwiga Marcinkiewicz

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Nasha Nassoury

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Harald Mayer

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Johannes Nimpf

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language of work or name

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publication date

25 January 2008

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Journal of Biological Chemistry

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283

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2363-72

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4

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Biomedicine. Lowering LDL--not only how low, but how long?

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https://api.crossref.org/works/10.1074%2FJBC.M708098200

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The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation

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NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol

1 reference

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Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

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The proprotein convertases and their implication in sterol and/or lipid metabolism

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Molecular biology of PCSK9: its role in LDL metabolism

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Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype

1 reference

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Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9

1 reference

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Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment

1 reference

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The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR

1 reference

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Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice

1 reference

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Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver.

1 reference

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A mutation in PCSK9 causing autosomal-dominant hypercholesterolemia in a Utah pedigree

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Mutations in the PCSK9 gene in Norwegian subjects with autosomal dominant hypercholesterolemia

1 reference

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Severe hypercholesterolemia in four British families with the D374Y mutation in the PCSK9 gene: long-term follow-up and treatment response

1 reference

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Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia

1 reference

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Effect of mutations in the PCSK9 gene on the cell surface LDL receptors

1 reference

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The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications

1 reference

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21 January 2018

Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation

1 reference

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Catalytic activity is not required for secreted PCSK9 to reduce low density lipoprotein receptors in HepG2 cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708098200

21 January 2018

The LDL receptor gene family: signaling functions during development.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708098200

21 January 2018

Multiple sequence alignment with hierarchical clustering

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708098200

21 January 2018

Reconstitution of the Reelin signaling pathway in fibroblasts demonstrates that Dab1 phosphorylation is independent of receptor localization in lipid rafts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708098200

21 January 2018

Alpha1-antitrypsin Portland inhibits processing of precursors mediated by proprotein convertases primarily within the constitutive secretory pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708098200

21 January 2018

Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708098200

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A secreted soluble form of ApoE receptor 2 acts as a dominant-negative receptor and inhibits Reelin signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708098200

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Receptor clustering is involved in Reelin signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708098200

21 January 2018

Down-regulation of alpha v/beta 3 integrin via misrouting to lysosomes by overexpression of a beta 3Lamp1 fusion protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708098200

21 January 2018

LIS1-no more no less

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708098200

21 January 2018

The proprotein convertases are potential targets in the treatment of dyslipidemia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708098200

21 January 2018

The cysteine-rich domain of the secreted proprotein convertases PC5A and PACE4 functions as a cell surface anchor and interacts with tissue inhibitors of metalloproteinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708098200

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A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9

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The targeting of Lamp1 to lysosomes is dependent on the spacing of its cytoplasmic tail tyrosine sorting motif relative to the membrane

1 reference

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Effects of pH and low density lipoprotein (LDL) on PCSK9-dependent LDL receptor regulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708098200

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Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2

1 reference

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Selective expression of LDLR and VLDLR in myelinating oligodendrocytes.

1 reference

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Modulation of lipoprotein receptor functions by intracellular adaptor proteins

1 reference

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Implication of the proprotein convertase NARC-1/PCSK9 in the development of the nervous system

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708098200

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Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708098200

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The C679X mutation in PCSK9 is present and lowers blood cholesterol in a Southern African population

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708098200

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Nerve growth factor and proprotein convertases furin and PC7 in transected sciatic nerves and in nerve segments cultured in conditioned media: their presence in Schwann cells, macrophages, and smooth muscle cells

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7 January 2021

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Complementation of mutations in the LDL pathway of receptor-mediated endocytosis by cocultivation of LDL receptor-defective hamster cell mutants

1 reference

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7 January 2021

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